Results 11 to 20 of about 34,497 (254)
Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities: Geriatrics Branch of Chinese Medical Association, Cardiovascular Group of Geriatrics Branch of Chinese Medical Association. [PDF]
Aging Med (Milton)Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Wang X, Zhang C.
europepmc +2 more sources
International Journal of Women's Dermatology, 2020 Background: Spironolactone is an off-label acne treatment that is commonly prescribed due to its low cost, efficacy, and tolerability. Objective: This study aimed to classify the most common adverse reactions associated with spironolactone in women of ...
Yu Wang, BA, Shari R. Lipner, MD, PhD
doaj +1 more source
Sex Differences in Spironolactone and the Active Metabolite Canrenone Concentrations and Adherence
Biomedicines, 2022 We aim to investigate sex differences in blood concentrations of spironolactone and the active metabolite canrenone in resistant hypertension patients.
Laura E. J. Peeters +5 more
doaj +1 more source
Pulmonary Circulation, 2021 Spironolactone, a common diuretic used in the treatment of pulmonary arterial hypertension (PAH), improves cardiopulmonary hemodynamics by attenuating the adverse effects of hyperaldosteronism on endothelin type‐B receptor function within pulmonary ...
Zeenat Safdar, Eunah Cho
doaj +1 more source
Frontiers in Medicine, 2021 Purpose: On the basis that spironolactone is involved in ACE2 expression and TMPRSS2 activity, previous studies have suggested that spironolactone may influence the infectivity of COVID-19.
Dongsub Jeon, Minkook Son, Jonggi Choi
doaj +1 more source
Medical treatment of ascites in cirrhosis [PDF]
, 1993 Medical treatment of cirrhotic ascites is essentially supportive, dictated by the patient's discomfort, impaired cardiovascular or respiratory function and potential for infection. Treatment of ‘simple’ ascites (moderate fluid accumulation, serum albumin
Gerbes, Alexander L.
core +1 more source
Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2:protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension [PDF]
, 2015 INTRODUCTION: Resistant hypertension is inadequately controlled blood pressure (BP) despite treatment with at least three BP-lowering drugs. A popular hypothesis is that resistant hypertension is due to excessive Na(+)-retention, and that 'further ...
Williams, B +25 more
core +2 more sources
Archives of Medical Science, 2019 Introduction The aim of the current study was to evaluate the association of spironolactone and arterial stiffness and composite cardiovascular disease (CVD, including coronary heart disease, congestive heart failure and ischemic stroke) in hypertensive ...
Fanfang Zeng +5 more
doaj +1 more source
Clinical and Translational Science, 2022 This phase Ib study compared the effects of AZD9977, a selective mineralocorticoid receptor modulator with predicted low hyperkalemia risk, with spironolactone on serum potassium (sK+) in patients with heart failure (HF) with preserved or mildly reduced ...
Iain B. Squire +11 more
doaj +1 more source
International Journal of Endocrinology, 2022 Metformin and spironolactone alone can be used for the management of polycystic ovarian syndrome (PCOS), and their combination could result in even better outcomes.
Tao Long +5 more
doaj +1 more source