Results 11 to 20 of about 33,667 (245)

Predictors of treatment response to subthreshold micropulse laser and oral spironolactone therapy for central serous chorioretinopathy [PDF]

BMC Ophthalmology
Objectives To identify the specific predictors of treatment response to subthreshold micropulse laser (SML) and oral spironolactone therapy in patients with central serous chorioretinopathy (CSC).
Sheng Gao, Yun Zhang, Ge Ge, Meixia Zhang   +3 more
doaj   +2 more sources

Spironolactone [PDF]

Journal of Pain and Symptom Management, 2017
Therapeutic Reviews aim to provide essential independent information for health professionals about drugs used in palliative and hospice care. Additional content is available on www.palliativedrugs.com. Country-specific books (Hospice and Palliative Care Formulary USA, and Palliative Care Formulary, British and Canadian editions) are also available and
Laura Carone, Stephen G. Oxberry, Robert Twycross, Sarah Charlesworth, Mary Mihalyo, Andrew Wilcock   +5 more
  +7 more sources

Pharmacotherapy of patients with atrial fibrillation and restored sinus rhythm – is the medication with spironolactone beneficial in this case? [PDF]

Pharmacia, 2021
Objective: Atrial fibrillation is progressive disease with important health consequences, in which fibrosis is a key player. The aim of our study is to assess the effect of mineralcorticoid blockade on top of standard treatment in patients with atrial ...
Antoniya Kisheva, Yoto Yotov, Evgeni Grigorov   +2 more
doaj   +3 more sources

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities: Geriatrics Branch of Chinese Medical Association, Cardiovascular Group of Geriatrics Branch of Chinese Medical Association. [PDF]

Aging Med (Milton)
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Wang X, Zhang C.
europepmc   +2 more sources

Determination and Occurrence of Mineralocorticoids in Taihu Lake of China

Frontiers in Environmental Science, 2021
We developed a sensitive method for monitoring six natural (aldosterone) and synthetic mineralocorticoids (canrenone, spironolactone, 7β-spironolactone, 7α-thio spironolactone, and 7α-thiomethyl spironolactone) in sediment and water using ultra ...
Li Zhao, Hong Chang, Fuhong Sun, Hailei Su   +3 more
doaj   +1 more source

Mineralocorticoid Receptor Antagonists Mitigate Mitral Regurgitation-Induced Myocardial Dysfunction

Cells, 2022
Mitral regurgitation (MR), the disruption of the mitral valve, contributes to heart failure (HF). Under conditions of volume overload, excess mineralocorticoids promote cardiac fibrosis.
Wei-Ting Chang, Yu-Wen Lin, Chin-Yu Chen, Zhih-Cherng Chen, Jhih-Yuan Shih, Chia-Ching Wu, Chwan-Yau Luo, Ping-Yen Liu   +7 more
doaj   +1 more source

Efficacy of Spironolactone as an Adjunctive Therapy to Risperidone to Improve Symptoms of Schizophrenia: A Double-Blind, Randomized, Placebo-Controlled, Clinical Trial

Iranian Journal of Psychiatry, 2021
Objective: Spironolactone (C24H32O4S), a potent mineralocorticoid receptor (MR) inhibitor, is a potassium-sparing diuretic that is traditionally used to treat fluid build-up in the body or for its anti-androgenic properties. This study is a double-blind,
Atefeh Zandifar, Rahim Badrfam, Hossein Sanjari Moghaddam, Shahin Akhondzadeh   +3 more
doaj   +1 more source

The Effect of Spironolactone on β-amyloid-Induced Memory Impairment in Male Rats: The Role of Microglial Inhibition [PDF]

Advanced Pharmaceutical Bulletin, 2022
Purpose: Neuroinflammation was indicated in the pathophysiology of Alzheimer’s disease(AD). Previous reports have also signified that spironolactone has anti-inflammatory effects.Therefore, the aim of this study was to assess the modulatory effects of ...
Mohammad Mehdipour, Masoumeh Emamghoreishi, Majid Reza Farrokhi, Elahe Amirinezhadfard, Mojtaba Keshavarz   +4 more
doaj   +1 more source

Retrospective analysis of adverse events with spironolactone in females reported to the United States Food and Drug Administration

International Journal of Women's Dermatology, 2020
Background: Spironolactone is an off-label acne treatment that is commonly prescribed due to its low cost, efficacy, and tolerability. Objective: This study aimed to classify the most common adverse reactions associated with spironolactone in women of ...
Yu Wang, BA, Shari R. Lipner, MD, PhD
doaj   +1 more source

Effect of Spironolactone on COVID-19 in Patients With Underlying Liver Cirrhosis: A Nationwide Case-Control Study in South Korea

Frontiers in Medicine, 2021
Purpose: On the basis that spironolactone is involved in ACE2 expression and TMPRSS2 activity, previous studies have suggested that spironolactone may influence the infectivity of COVID-19.
Dongsub Jeon, Minkook Son, Jonggi Choi
doaj   +1 more source