Results 11 to 20 of about 27,289 (199)
Sex Differences in Spironolactone and the Active Metabolite Canrenone Concentrations and Adherence
Biomedicines, 2022 We aim to investigate sex differences in blood concentrations of spironolactone and the active metabolite canrenone in resistant hypertension patients.
Laura E. J. Peeters +5 more
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Pulmonary Circulation, 2021 Spironolactone, a common diuretic used in the treatment of pulmonary arterial hypertension (PAH), improves cardiopulmonary hemodynamics by attenuating the adverse effects of hyperaldosteronism on endothelin type‐B receptor function within pulmonary ...
Zeenat Safdar, Eunah Cho
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Clinical and Translational Science, 2022 This phase Ib study compared the effects of AZD9977, a selective mineralocorticoid receptor modulator with predicted low hyperkalemia risk, with spironolactone on serum potassium (sK+) in patients with heart failure (HF) with preserved or mildly reduced ...
Iain B. Squire +11 more
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International Journal of Endocrinology, 2022 Metformin and spironolactone alone can be used for the management of polycystic ovarian syndrome (PCOS), and their combination could result in even better outcomes.
Tao Long +5 more
doaj +1 more source
Archives of Medical Science, 2019 Introduction The aim of the current study was to evaluate the association of spironolactone and arterial stiffness and composite cardiovascular disease (CVD, including coronary heart disease, congestive heart failure and ischemic stroke) in hypertensive ...
Fanfang Zeng +5 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Renal sodium retention is an essential indicator that is used for the prognosis of cirrhosis with ascites that requires diuretic treatment to restore sodium homeostasis.
Tun-Pin Hsueh +5 more
doaj +1 more source
Influence of Spironolactone on Matrix Metalloproteinase-2 in Acute Decompensated Heart Failure
Arquivos Brasileiros de Cardiologia, 2015 Background: Matrix metalloproteinases (MMPs) are a family of enzymes important for the resorption of extracellular matrices, control of vascular remodeling and repair.
João Pedro Ferreira +5 more
doaj +1 more source
Effects of Spironolactone and Losartan on Diabetic Nephropathy in a Type 2 Diabetic Rat Model [PDF]
Diabetes & Metabolism Journal, 2011 BackgroundWhile there is an evidence that the anti-inflammatory properties of spironolactone can attenuate proteinuria in type 2 diabetes, its effects on vascular endothelial growth factor (VEGF) expression in diabetic nephropathy have not been clearly ...
Mi Young Lee +10 more
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International Journal of Women's Dermatology, 2019 Purpose: The necessity of serum potassium monitoring for healthy women who are prescribed spironolactone for acne has been debated. The aim of this study was to compare the incidence of hyperkalemia in women 18 to 45 years of age to that in women 46 to ...
Rebecca M. Thiede +6 more
doaj +1 more source
Outcomes of Spironolactone Withdrawal in Dilated Cardiomyopathy With Improved Ejection Fraction
Frontiers in Cardiovascular Medicine, 2021 Background: The feasibility of spironolactone withdrawal in dilated cardiomyopathy patients with improved ejection fraction remains unknown. This study sought to determine whether spironolactone can be withdrawn safely in this circumstance.Methods ...
Yanjia Chen +10 more
doaj +1 more source