Results 1 to 10 of about 215,682 (163)

Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3

Acta Pharmaceutica Sinica B, 2019
Excess activation of cardiac fibroblasts inevitably induces cardiac fibrosis. Emodin has been used as a natural medicine against several chronic diseases.
Dan Xiao, Yue Zhang, Rui Wang, Yujie Fu, Tong Zhou, Hongtao Diao, Zhixia Wang, Yuan Lin, Zhange Li, Lin Wen, Xujuan Kang, Philipp Kopylov, Dmitri Shchekochikhin, Yong Zhang, Baofeng Yang   +14 more
doaj   +3 more sources

Vascular peroxidase 1 is a novel regulator of cardiac fibrosis after myocardial infarction

Redox Biology, 2019
Cardiac fibrosis is the most important mechanism contributing to cardiac remodeling after myocardial infarction (MI). VPO1 is a heme enzyme that uses hydrogen peroxide (H2O2) to produce hypochlorous acid (HOCl).
Zhaoya Liu, Qian Xu, Qixin Yang, Jing Cao, Cong Wu, Huihui Peng, Xinyi Zhang, Jia Chen, Guangjie Cheng, Yueheng Wu, Ruizheng Shi, Guogang Zhang   +11 more
doaj   +3 more sources

Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1 [PDF]

Redox Biology
Cardiac fibrosis remains an unresolved clinical issue in patients with heart diseases. CircRNAs have emerged as potential targets for treatment of heart diseases.
Yan Chen, Zhewei Zhang, Yue Cheng, Xiaofeng Chen, Junteng Zhou, Zisong Wei, Han Yao, Shuwen Zhang, Qihang Kong, Hao Tang, Wenchao Wu, Zhichao Zhou, Xiaoqiang Tang, Xiaojing Liu   +13 more
doaj   +2 more sources

MicroRNA-24-3p alleviates cardiac fibrosis by suppressing cardiac fibroblasts mitophagy via downregulating PHB2

Pharmacological Research, 2022
Cardiac fibrosis is a pathological process of multiple cardiovascular diseases, which may lead to heart failure. Studies have shown that microRNAs (miRNAs) play critical roles in regulating mitophagy and cardiac fibrosis.
Yue Zhang, Zhiying Wang, Dingming Lan, Jingjing Zhao, Lexun Wang, Xiaoqi Shao, Dongwei Wang, Kaili Wu, Mengxian Sun, Xueying Huang, Meiling Yan, Haihai Liang, Xianglu Rong, Hongtao Diao, Jiao Guo   +14 more
doaj   +3 more sources

Exploring the cardiac ECM during fibrosis: A new era with next-gen proteomics

Frontiers in Molecular Biosciences, 2022
Extracellular matrix (ECM) plays a critical role in maintaining elasticity in cardiac tissues. Elasticity is required in the heart for properly pumping blood to the whole body. Dysregulated ECM remodeling causes fibrosis in the cardiac tissues.
Vivek Sarohi, Vivek Sarohi, Sanchari Chakraborty, Sanchari Chakraborty, Trayambak Basak, Trayambak Basak   +5 more
doaj   +1 more source

Clostridium butyricum and Bifidobacterium pseudolongum Attenuate the Development of Cardiac Fibrosis in Mice

Microbiology Spectrum, 2022
Cardiac fibrosis is an integral aspect of every form of cardiovascular diseases, which is one of the leading causes of death worldwide. It is urgent to explore new effective drugs and treatments.
Jiaqi Wang, Jiahuan Chen, Linquan Li, Huanyu Zhang, Daxin Pang, Hongsheng Ouyang, Xuemin Jin, Xiaochun Tang   +7 more
doaj   +1 more source

Chemokines in cardiac fibrosis

Current Opinion in Physiology, 2021
Several members of the chemokine family are involved in regulation of fibrosis. This review manuscript discusses the role of the chemokines in the pathogenesis of myocardial fibrosis. The CC chemokine CCL2 exerts fibrogenic actions through recruitment and activation of monocytes and macrophages expressing its receptor, CCR2.
Ruoshui, Li, Nikolaos G, Frangogiannis
openaire   +3 more sources

Leonurine inhibits cardiomyocyte pyroptosis to attenuate cardiac fibrosis via the TGF-β/Smad2 signalling pathway.

PLoS ONE, 2022
Cardiac fibrosis is a common cause of most cardiovascular diseases. Leonurine, an alkaloid from Herba leonuri, had been indicated to treat cardiovascular diseases due to its cardioprotective effects.
Zhaoyi Li, Keyuan Chen, Yi Zhun Zhu
doaj   +1 more source

Cardiac fibrosis [PDF]

Cardiovascular Research, 2020
AbstractMyocardial fibrosis, the expansion of the cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic companion of many different myocardial conditions. Fibrosis may reflect activation of reparative or maladaptive processes. Activated fibroblasts and myofibroblasts are the central cellular effectors in
openaire   +2 more sources

Cardiac Fibrosis [PDF]

Circulation Research, 2016
Myocardial fibrosis is a significant global health problem associated with nearly all forms of heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is responsible for the homeostasis of the extracellular matrix; however, upon injury, these cells transform to a myofibroblast phenotype and contribute to cardiac fibrosis ...
Joshua G, Travers, Fadia A, Kamal, Jeffrey, Robbins, Katherine E, Yutzey, Burns C, Blaxall   +4 more
openaire   +2 more sources