Results 1 to 10 of about 1,128,571 (299)

Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3

Acta Pharmaceutica Sinica B, 2019
Excess activation of cardiac fibroblasts inevitably induces cardiac fibrosis. Emodin has been used as a natural medicine against several chronic diseases.
Dan Xiao, Yue Zhang, Rui Wang, Yujie Fu, Tong Zhou, Hongtao Diao, Zhixia Wang, Yuan Lin, Zhange Li, Lin Wen, Xujuan Kang, Philipp Kopylov, Dmitri Shchekochikhin, Yong Zhang, Baofeng Yang   +14 more
doaj   +3 more sources

Vascular peroxidase 1 is a novel regulator of cardiac fibrosis after myocardial infarction

Redox Biology, 2019
Cardiac fibrosis is the most important mechanism contributing to cardiac remodeling after myocardial infarction (MI). VPO1 is a heme enzyme that uses hydrogen peroxide (H2O2) to produce hypochlorous acid (HOCl).
Zhaoya Liu, Qian Xu, Qixin Yang, Jing Cao, Cong Wu, Huihui Peng, Xinyi Zhang, Jia Chen, Guangjie Cheng, Yueheng Wu, Ruizheng Shi, Guogang Zhang   +11 more
doaj   +3 more sources

Exploring the cardiac ECM during fibrosis: A new era with next-gen proteomics

Frontiers in Molecular Biosciences, 2022
Extracellular matrix (ECM) plays a critical role in maintaining elasticity in cardiac tissues. Elasticity is required in the heart for properly pumping blood to the whole body. Dysregulated ECM remodeling causes fibrosis in the cardiac tissues.
Vivek Sarohi, Vivek Sarohi, Sanchari Chakraborty, Sanchari Chakraborty, Trayambak Basak, Trayambak Basak   +5 more
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Clostridium butyricum and Bifidobacterium pseudolongum Attenuate the Development of Cardiac Fibrosis in Mice

Microbiology Spectrum, 2022
Cardiac fibrosis is an integral aspect of every form of cardiovascular diseases, which is one of the leading causes of death worldwide. It is urgent to explore new effective drugs and treatments.
Jiaqi Wang, Jiahuan Chen, Linquan Li, Huanyu Zhang, Daxin Pang, Hongsheng Ouyang, Xuemin Jin, Xiaochun Tang   +7 more
doaj   +1 more source

Leonurine inhibits cardiomyocyte pyroptosis to attenuate cardiac fibrosis via the TGF-β/Smad2 signalling pathway.

PLoS ONE, 2022
Cardiac fibrosis is a common cause of most cardiovascular diseases. Leonurine, an alkaloid from Herba leonuri, had been indicated to treat cardiovascular diseases due to its cardioprotective effects.
Zhaoyi Li, Keyuan Chen, Yi Zhun Zhu
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Zanubrutinib Ameliorates Cardiac Fibrosis and Inflammation Induced by Chronic Sympathetic Activation

Molecules, 2023
(1) Background: Heart failure (HF) is the final stage of multiple cardiac diseases, which have now become a severe public health problem worldwide.
Wenqi Li, Shuwen Zhu, Jing Liu, Zhigang Liu, Honggang Zhou, Qianyi Zhang, Yue Yang, Li Chen, Xiaowei Guo, Tiantian Zhang, Lingxin Meng, Dan Chai, Guodong Tang, Xiaohe Li, Cheng Yang   +14 more
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Promising Therapeutic Treatments for Cardiac Fibrosis: Herbal Plants and Their Extracts

Cardiology and Therapy, 2023
Cardiac fibrosis is closely associated with multiple heart diseases, which are a prominent health issue in the global world. Neurohormones and cytokines play indispensable roles in cardiac fibrosis. Many signaling pathways participate in cardiac fibrosis
Xuejing Yu
doaj   +1 more source

Proteomic Insights into Cardiac Fibrosis: From Pathophysiological Mechanisms to Therapeutic Opportunities

Molecules, 2022
Cardiac fibrosis is a common pathophysiologic process in nearly all forms of heart disease which refers to excessive deposition of extracellular matrix proteins by cardiac fibroblasts.
Ruiqiang Qi, E. Lin, Juan Song, Yan Wang, Ling Lin   +4 more
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Different Roles of Resident and Non-resident Macrophages in Cardiac Fibrosis

Frontiers in Cardiovascular Medicine, 2022
Cardiac fibrosis is a key pathological link of various cardiovascular diseases to heart failure. It is of great significance to deeply understand the development process of cardiac fibrosis and the cellular and molecular mechanisms involved.
Siyuan Hu, Siyuan Hu, Meng Yang, Meng Yang, Shumin Huang, Shumin Huang, Senjie Zhong, Senjie Zhong, Qian Zhang, Qian Zhang, Haichao Ding, Xiajun Xiong, Xiajun Xiong, Zhixi Hu, Yi Yang   +14 more
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Long Non-Coding RNA 554 Promotes Cardiac Fibrosis via TGF-β1 Pathway in Mice Following Myocardial Infarction

Frontiers in Pharmacology, 2020
Rationale: Cardiac fibrosis is observed in nearly every form of myocardial disease. Long non-coding RNAs (lncRNAs) have been shown to play an important role in cardiac fibrosis, but the detailed molecular mechanism remains unknown.Object: We aimed at ...
Bihui Luo, Zhiyu He, Shijun Huang, Shijun Huang, Jinping Wang, Dunzheng Han, Hao Xue, Peiying Liu, Xiaojun Zeng, Dongfeng Lu   +9 more
doaj   +1 more source