Results 41 to 50 of about 215,781 (262)

Epigenetic regulation of cardiac fibrosis [PDF]

Journal of Molecular and Cellular Cardiology, 2016
Fibrosis is defined as excess deposition of extracellular matrix (ECM), resulting in tissue scarring and organ dysfunction. In the heart, fibrosis may be reparative, replacing areas of myocyte loss with a structural scar following infarction, or reactive, which is triggered in the absence of cell death and involves interstitial ECM deposition in ...
Matthew S, Stratton, Timothy A, McKinsey
openaire   +2 more sources

The long noncoding RNA THBS1-AS1 promotes cardiac fibroblast activation in cardiac fibrosis by regulating TGFBR1

JCI Insight, 2023
Cardiac fibrosis is associated with an adverse prognosis in cardiovascular disease that results in a decreased cardiac compliance and, ultimately, heart failure.
Junteng Zhou, Geer Tian, Yue Quan, Qihang Kong, Fangyang Huang, Junli Li, Wenchao Wu, Yong Tang, Zhichao Zhou, Xiaojing Liu   +9 more
doaj   +1 more source

Macrophage-Mediated Cardiac Fibrosis [PDF]

Circulation Research, 2004
See related article, pages 637–644 Both clinicians and investigators have long tended to consider cardiac fibrosis as a hopelessly unavoidable “final common pathway” of tissue injury. We are painfully familiar with the serious consequences of myocardial fibrosis, including diastolic dysfunction and promoting reentry dysrhythmias,1 but we seem to ...
P Christian, Schulze, Richard T, Lee
openaire   +2 more sources

IGF-1 protects against angiotensin II-induced cardiac fibrosis by targeting αSMA

Cell Death and Disease, 2021
The insulin-like growth factor 1 receptor (IGF-1R) signaling in cardiomyocytes is implicated in physiological hypertrophy and myocardial aging. Although fibroblasts account for a small amount of the heart, they are activated when the heart is damaged to ...
Sangmi Ock, Woojin Ham, Chae Won Kang, Hyun Kang, Wang Soo Lee, Jaetaek Kim   +5 more
doaj   +1 more source

Atrial fibrillation and cardiac fibrosis

European Heart Journal, 2019
Abstract The understanding of atrial fibrillation (AF) evolved from a sole rhythm disturbance towards the complex concept of a cardiomyopathy based on arrhythmia substrates. There is evidence that atrial fibrosis can be visualized using late gadolinium enhancement cardiac magnetic resonance imaging and that it is a powerful predictor for
Christian Sohns, Nassir F Marrouche
openaire   +2 more sources

Tripartite motif 38 attenuates cardiac fibrosis after myocardial infarction by suppressing TAK1 activation via TAB2/3 degradation

iScience, 2022
Summary: The role of tripartite motif (TRIM) 38, a ubiquitin E3 ligase regulating various pathophysiological processes, in cardiac fibrosis remains unclear.
Zhengri Lu, Chunshu Hao, Hao Qian, Yuanyuan Zhao, Xiangwei Bo, Yuyu Yao, Genshan Ma, Lijuan Chen   +7 more
doaj   +1 more source

Survival in infants with trisomy 18, palliative care and ethical reflections: a single center considerations

Italian Journal of Pediatrics
Background Trisomy 18 was once considered a fatal diagnosis due to the presence of cardiac and extracardiac lesions. However, with the increasing use of therapeutic management, 3% to 25% of infants with trisomy 18 may survive beyond their first year ...
Serena Caggiano, Sabrina Persia, Francesco D’Amore, Marina Macchiaiolo, Maria Fornari, Vitangelo Clemente, Maria Giovanna Paglietti, Alessandra Schiavino, Gianfranco Butera, Sergio Filippelli, Luigi Zucaro, Renato Cutrera   +11 more
doaj   +1 more source

Misperception of Body Weight After Childhood Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Misperception of body weight can negatively impact the weight management efforts of childhood cancer survivors (CCSs). Both being overweight or underweight are associated with chronic health conditions commonly observed in CCS; therefore, accurate weight perception is critical for reducing long‐term health risks.
Fabiën N. Belle, Tomáš Sláma, Eva Haegler‐Laube, Reto D. Kurmann, Gabriela M. Kuster, Christoph Saner, Eva Scheler, Yara Shoman, Christina Schindera   +8 more
wiley   +1 more source

Miglustat ameliorates isoproterenol-induced cardiac fibrosis via targeting UGCG

Molecular Medicine
Background Cardiac fibrosis is significant global health problem, which is associated with numerous cardiovascular diseases, and ultimately leads to the progression to heart failure.
Jing Liu, Wenqi Li, Ran Jiao, Zhigang Liu, Tiantian Zhang, Dan Chai, Lingxin Meng, Zhongyi Yang, Yuming Liu, Hongliang Wu, Xiaoting Gu, Xiaohe Li, Cheng Yang   +12 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source