Results 31 to 40 of about 1,128,571 (299)

Targeting GPCRs to treat cardiac fibrosis

Frontiers in Cardiovascular Medicine, 2022
Cardiac fibrosis occurs ubiquitously in ischemic heart failure, genetic cardiomyopathies, diabetes mellitus, and aging. It triggers myocardial stiffness, which impairs cardiac function, ultimately progressing to end-stage heart failure and increased ...
Hao Zhang, Lu Ren, Rabindra Vishwadev Shivnaraine   +2 more
doaj   +1 more source

MicroRNAs in fibrosis: opportunities and challenges [PDF]

, 2016
MicroRNAs (miRNAs) are small, non-coding RNAs that mediate mRNA cleavage, translational repression or mRNA destabilisation and are around 22-25 nucleotides in length via partial complementary binding to the 3' untranslated region in target transcripts ...
O'Reilly, Steven, Steven O’Reilly
core   +1 more source

Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances

Frontiers in Physiology, 2020
Cardiac fibrosis is a common pathological change associated with cardiac injuries and diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) proteins may have some protective effects in certain situations, prolonged ...
Xing Fu, Qianglin Liu, Chaoyang Li, Yuxia Li, Leshan Wang   +4 more
doaj   +1 more source

Mechanism of action of non-coding RNAs and traditional Chinese medicine in myocardial fibrosis: Focus on the TGF-β/Smad signaling pathway

Frontiers in Pharmacology, 2023
Cardiac fibrosis is a serious public health problem worldwide that is closely linked to progression of many cardiovascular diseases (CVDs) and adversely affects both the disease process and clinical prognosis.
Chunjun Li, Xiangxiang Meng, Lina Wang, Xia Dai   +3 more
doaj   +1 more source

Ventilation inhomogeneity in patients with cystic fibrosis measured by electrical impedance tomography [PDF]

, 2012
Objective: The distribution of ventilation within the lung is inhomogeneous. We hypothesized that the degree of inhomogeneity in patients with cystic fibrosis (CF) differs from that in healthy subjects.
Zhao, Zhanqi, Mueller-Lisse, Ullrich, Moeller, Knut, Fischer, Rainald   +3 more
core   +1 more source

Trimethylamine N-Oxide Exacerbates Cardiac Fibrosis via Activating the NLRP3 Inflammasome

Frontiers in Physiology, 2019
Background/Aims: Gut microbiota has been reported to correlate with a higher mortality and worse prognosis of cardiovascular diseases. Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of specific dietary nutrients, which is linked ...
Xueling Li, Jin Geng, Jinxuan Zhao, Qianqian Ni, Chenze Zhao, Yaru Zheng, Xiaomin Chen, Lihong Wang   +7 more
doaj   +1 more source

Review: Acetylation mechanisms and targeted therapies in cardiac fibrosis

Pharmacological Research, 2023
Cardiac fibrosis is a common pathophysiological remodeling process that occurs in a variety of cardiovascular diseases and greatly influences heart structure and function, progressively leading to the development of heart failure.
Weikang Liu, Qiuhuan Yuan, Shengchuan Cao, Guoying Wang, Xiangguo Liu, Yanan Xia, Yuan Bian, Feng Xu, Yuguo Chen   +8 more
doaj   +1 more source

High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis [PDF]

, 2014
AIMS: High-sensitivity cardiac troponin I (cTnI) assays hold promise in detecting the transition from hypertrophy to heart failure in aortic stenosis.
Lang, Chim C., Langrish, Jeremy P, Langrish, Jeremy P., Newby, David E., Shah, Anoop, Dweck, Marc R, Alam, Shirjel, Mills, Nicholas L; id_orcid, McAllister, David A, Hunter, Amanda L., Cowell, S. Joanna, Boon, Nicholas A, Shah, Anoop S.V., Strachan, Fiona E, McAllister, David A., Maria Choy, Anna; id_orcid, Strachan, Fiona E., Boon, Nicholas A., Mills, Nicholas L., Dweck, Marc R., Shah, Anoop S. V., Newby, David E, Lang, Chim C.; id_orcid, Chin, Calvin W.L., Chin, Calvin W L, Chin, Calvin W. L., Joanna Cowell, S, Maria Choy, Anna, Walker, Simon, Lang, Chim C, Hunter, Amanda L   +30 more
core   +1 more source

Targeted exhaled breath analysis for detection of Pseudomonas aeruginosa in cystic fibrosis patients [PDF]

, 2021
Background Pseudomonas aeruginosa (PA) is an important respiratory pathogen for cystic fibrosis (CF) patients. Routine microbiology surveillance is time-consuming, and is best performed on expectorated sputum. As alternative, volatile organic compounds (
Davies, Jane, Gerritsen, Marije, Lammers, Ariana, Kraneveld, Aletta, Neerincx, Anne, Janssens, Hettie, Haarman, Eric, on behalf of the Amsterdam Mucociliary Clearance Disease (AMCD) Research Group and the Amsterdam UMC Breath Research Group, Weersink, Els, Maitland-van der Zee, Anke, Majoor, Christof, Sterk, Peter, Kos, Renate, Brinkman, Paul, Paff, Tamara, Bos, Lieuwe, Heijerman, Harry   +16 more
core   +1 more source

Periostin-CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy. [PDF]

Adv Sci (Weinh)
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Wu T, Li R, Zhang X, Chen D, Yang J, Li M, Yin Y, Wang Y, Tian Y, Yan H, Cui D, Song J, Ouyang G.   +12 more
europepmc   +2 more sources