Results 31 to 40 of about 215,781 (262)
Frontiers in Pharmacology, 2023 Cardiac fibrosis is a serious public health problem worldwide that is closely linked to progression of many cardiovascular diseases (CVDs) and adversely affects both the disease process and clinical prognosis.
Chunjun Li +3 more
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Review: Acetylation mechanisms and targeted therapies in cardiac fibrosis
Pharmacological Research, 2023 Cardiac fibrosis is a common pathophysiological remodeling process that occurs in a variety of cardiovascular diseases and greatly influences heart structure and function, progressively leading to the development of heart failure.
Weikang Liu +8 more
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Noncoding RNAs and Cardiac Fibrosis
Reviews in Cardiovascular Medicine, 2023 Myocardial fibrosis is a common pathological feature of various terminal cardiovascular diseases. Progressive fibrosis is the pathological basis for the development and progression of many cardiac arrhythmias and heart failure. There are no effective reversal drugs for myocardial fibrosis due to the lack of understanding of the molecular mechanisms ...
Changyong Wu +4 more
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Trimethylamine N-Oxide Exacerbates Cardiac Fibrosis via Activating the NLRP3 Inflammasome
Frontiers in Physiology, 2019 Background/Aims: Gut microbiota has been reported to correlate with a higher mortality and worse prognosis of cardiovascular diseases. Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of specific dietary nutrients, which is linked ...
Xueling Li +7 more
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Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention
Frontiers in Pharmacology, 2023 Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and extracellular matrix collagen deposition are the hallmarks of cardiac ...
Xiaoying Yin +40 more
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Cardiac fibrosis and miR-433 [PDF]
Annals of Translational Medicine, 2016 Heart failure (HF) is a major cause of morbidity and mortality (1). It affects approximately 5.4 million people in the United States with an incidence of 690,000 cases/year (2). Cardiac fibrosis (CF) has traditionally been regarded as a secondary phenomenon in the pathogenesis of HF.
Jae Gyun, Oh +2 more
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Medicina, 2023 Background and Objectives: Advanced liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) can be a major predictor of cardiovascular disease (CVD) events and cardiac complications. However, the clinical significance of cardiac symptoms
Min-Kyu Kang, Min-Cheol Kim
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Therapeutic Potential of Polyphenols in Cardiac Fibrosis
Frontiers in Pharmacology, 2018 Cardiac fibrosis, in response to injury and stress, is central to a broad constellation of cardiovascular diseases. Fibrosis decreases myocardial wall compliance due to extracellular matrix (ECM) accumulation, leading to impaired systolic and diastolic ...
Ning Zhang +14 more
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Redox Biology, 2023 Cardiac fibrosis is characterized by the excessive deposition of extracellular matrix in the myocardium with cardiac fibroblast activation, leading to chronic cardiac remodeling and dysfunction.
Geer Tian +8 more
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