Results 11 to 20 of about 1,128,571 (299)
Fighting time: A qualitative analysis on the impact of lung transplantation in adults with Cystic Fibrosis [PDF]
, 2001 During the last decade lung transplantation has become an option for those with end-stage respiratory disease, including Cystic Fibrosis. However, there appears to have been very little written about the experiences of those who are on the lung ...
McCarthy, Janet Mary
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Chemokines and cardiac fibrosis [PDF]
Frontiers in Bioscience, 2009 Several members of the chemokine family play an important role in reparative fibrosis and are involved in the pathogenesis of remodeling following myocardial infarction. Chemokines may regulate the fibrotic process through recruitment and activation of mononuclear cell subsets and fibroblast progenitors (fibrocytes), by exerting direct effects on ...
Marcin, Dobaczewski +1 more
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Circulation Research, 2016 Myocardial fibrosis is a significant global health problem associated with nearly all forms of heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is responsible for the homeostasis of the extracellular matrix; however, upon injury, these cells transform to a myofibroblast phenotype and contribute to cardiac fibrosis ...
Joshua G, Travers +4 more
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Chemokines in cardiac fibrosis
Current Opinion in Physiology, 2021 Several members of the chemokine family are involved in regulation of fibrosis. This review manuscript discusses the role of the chemokines in the pathogenesis of myocardial fibrosis. The CC chemokine CCL2 exerts fibrogenic actions through recruitment and activation of monocytes and macrophages expressing its receptor, CCR2.
Ruoshui, Li, Nikolaos G, Frangogiannis
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Cardiovascular Research, 2020 AbstractMyocardial fibrosis, the expansion of the cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic companion of many different myocardial conditions. Fibrosis may reflect activation of reparative or maladaptive processes. Activated fibroblasts and myofibroblasts are the central cellular effectors in
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Cardiac Fibrosis and Fibroblasts [PDF]
Cells, 2021 Cardiac fibrosis is the excess deposition of extracellular matrix (ECM), such as collagen. Myofibroblasts are major players in the production of collagen, and are differentiated primarily from resident fibroblasts. Collagen can compensate for the dead cells produced by injury.
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Endothelins and Cardiac Fibrosis [PDF]
Hypertension, 1999 To the Editor: In the March issue of Hypertension , Dr Hocher and colleagues reported on the role of the endothelin (ET) system in the cardiac remodeling of renovascular hypertension.1 According to their findings, both fibrosis of the left ventricle (LV) and hypertrophy of intracardiac arteries were markedly prevented in the 2-kidney, 1-clip (2K1C ...
G P, Rossi, M, Cesari, A C, Pessina
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Link between fibrosis-specific biomarkers and interstitial fibrosis in hypertrophic cardiomyopathy [PDF]
, 2023 Background: Cardiac fibrosis is a hallmark of hypertrophic cardiomyopathy (HCM) and has confirmed unfavorable clinical significance. Replacement fibrosis is better known and has already been studied on a larger scale, whereas interstitial fibrosis is ...
Karabinowska-Małocha, Aleksandra; Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Kraków, Poland; Jagiellonian University Medical College, Doctoral School of Medical and Health Sciences, Kraków, Poland +12 more
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The pathogenesis of cardiac fibrosis [PDF]
Cellular and Molecular Life Sciences, 2013 Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. This review discusses the cellular effectors and molecular pathways implicated in the pathogenesis of cardiac fibrosis.
Ping, Kong +2 more
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Immobilizing Interstitial Cardiac Fibrosis
Cardiology Research, 2023 The alterations in the endomysium and perimysium might cause compaction and gradual mechanical compression of cardiomyocytes resulting in their immobilization. This process finally leads to severe stiffening, so that the newly formed frame around individual cardiomyocytes and their clusters hinders normal diastole, and later systole. This phenomenon is
Yuriy L. Shevchenko +2 more
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