Results 1 to 10 of about 85,418 (114)

Metformin Inhibits Cardiac Fibroblast Differentiation by Promoting Fatty Acid β-Oxidation: Implications for Age-Associated Cardiac Fibrosis [PDF]

Cells
Cardiac fibrosis is a hallmark of pathological cardiac remodeling, characterized by fibroblast activation, excessive extracellular matrix deposition, and myocardial hypertrophy, ultimately leading to cardiac dysfunction. Aging exacerbates these processes
Hridya Chempon, Sunita Kumari, Srinivasa Reddy Bonam, Srigiridhar Kotamraju   +3 more
doaj   +2 more sources

Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances

Frontiers in Physiology, 2020
Cardiac fibrosis is a common pathological change associated with cardiac injuries and diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) proteins may have some protective effects in certain situations, prolonged ...
Xing Fu, Leshan Wang
exaly   +3 more sources

Cardiac fibroblast heterogeneity in cardiac fibrosis implication for cell-type-specific treatment [PDF]

Frontiers in Physiology
Cardiac fibrosis is a central feature of heart disease, driven by excessive extracellular matrix (ECM) accumulation and associated with mechanical stiffening, electrical instability, and heart failure.
Kai Gu, Dongyan Song, Jisheng Chen
doaj   +2 more sources

Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism [PDF]

Scientific Reports
Excessive fibroblast proliferation and metabolic reprogramming are hallmarks of pathological cardiac remodeling, contributing significantly to impaired cardiac function. This study investigates the role of circular RNAs (circRNAs) in fibroblast metabolic
Arne Schmidt, Kevin Schmidt, Sonja Groß, Dongchao Lu, Ke Xiao, Dimyana Neufeldt, Sarah Cushman, Nele Lehmann, Sabrina Thum, Angelika Pfanne, Annette Just, Andreas Pich, Alexander Heinz, Karsten Hiller, Hannah Jill Hunkler, Wilson Lek Wen Tan, Roger Foo, Christian Bär, Thomas Thum, Mira Jung   +19 more
doaj   +2 more sources

Sulfenylation of ERK1/2: A novel mechanism for SO2-mediated inhibition of cardiac fibroblast proliferation [PDF]

Heliyon
Background: Endogenous sulfur dioxide (SO2) plays a crucial role in protecting heart from myocardial fibrosis by inhibiting the excessive growth of cardiac fibroblasts.
Mei Ge, Lulu Zhang, Junbao Du, Hongfang Jin, Boyang Lv, Yaqian Huang   +5 more
doaj   +2 more sources

The Impact of Diabetic Conditions and AGE/RAGE Signaling on Cardiac Fibroblast Migration

Frontiers in Cell and Developmental Biology, 2020
Diabetic individuals have an increased risk for developing cardiovascular disease due to stiffening of the left ventricle (LV), which is thought to occur, in part, by increased AGE/RAGE signaling inducing fibroblast differentiation. Advanced glycated end-

exaly   +3 more sources

Voltage-dependent anion channel 1 (VDAC1) overexpression alleviates cardiac fibroblast activation in cardiac fibrosis via regulating fatty acid metabolism

Redox Biology, 2023
Cardiac fibrosis is characterized by the excessive deposition of extracellular matrix in the myocardium with cardiac fibroblast activation, leading to chronic cardiac remodeling and dysfunction.
Geer Tian, Junteng Zhou, Yue Quan, Qihang Kong, Junli Li, Yanguo Xin, Wenchao Wu, Xiaoqiang Tang, Xiaojing Liu   +8 more
doaj   +1 more source

WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation

iScience, 2023
Summary: Dysregulated lipid metabolism occurs in pathological processes characterized by cell proliferation and migration. Nonetheless, the mechanism of increased mitochondrial lipid oxidation is poorly appreciated in diabetic cardiac fibrosis, which is ...
Kai Song, He Sun, Bin Tu, Yang Zhou, Li-Chan Lin, Zhi-Yan Liu, Rui Li, Jing-Jing Yang, Ye Zhang, Jian-Yuan Zhao, Hui Tao   +10 more
doaj   +1 more source

Mechanism of fibroblast growth factor 21 in cardiac remodeling

Frontiers in Cardiovascular Medicine, 2023
Cardiac remodeling is a basic pathological process that enables the progression of multiple cardiac diseases to heart failure. Fibroblast growth factor 21 is considered a regulator in maintaining energy homeostasis and shows a positive role in preventing
Zeyu Zhao, Xuemei Cui, Zhangping Liao
doaj   +1 more source

METTL3 boosts mitochondrial fission and induces cardiac fibrosis by enhancing LncRNA GAS5 methylation

Pharmacological Research, 2023
Dysregulated mitochondrial metabolism occurs in several pathological processes characterized by cell proliferation and migration. Nonetheless, the role of mitochondrial fission is not well appreciated in cardiac fibrosis, which is accompanied by enhanced
Bin Tu, Kai Song, Yang Zhou, He Sun, Zhi-Yan Liu, Li-Chan Lin, Ji-Fei Ding, Ji-Ming Sha, Yan Shi, Jing-Jing Yang, Rui Li, Ye Zhang, Jian-Yuan Zhao, Hui Tao   +13 more
doaj   +1 more source