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Origins of Cardiac Fibroblasts [PDF]

Circulation Research, 2010
Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions, cardiac fibroblasts remain poorly characterized in molecular terms.
Raghu Kalluri, Elisabeth M Zeisberg
exaly   +5 more sources

Cardiac Fibroblasts: Helping or Hurting. [PDF]

Genes (Basel)
Cardiac fibroblasts (CFs) are the essential cell type for heart morphogenesis and homeostasis. In addition to maintaining the structural integrity of the heart tissue, muscle fibroblasts are involved in complex signaling cascades that regulate cardiomyocyte proliferation, migration, and maturation. While CFs serve as the primary source of extracellular
Shameem M, Olson SL, Marron Fernandez de Velasco E, Kumar A, Singh BN.   +4 more
europepmc   +4 more sources

Cardiac Fibrosis and Fibroblasts [PDF]

Cells, 2021
Cardiac fibrosis is the excess deposition of extracellular matrix (ECM), such as collagen. Myofibroblasts are major players in the production of collagen, and are differentiated primarily from resident fibroblasts. Collagen can compensate for the dead cells produced by injury.
Hitoshi Kurose
openaire   +4 more sources

Induction of Senescence by Loss of Gata4 in Cardiac Fibroblasts

Cells, 2023
Cardiac fibroblasts are a major source of cardiac fibrosis during heart repair processes in various heart diseases. Although it has been shown that cardiac fibroblasts become senescent in response to heart injury, it is unknown how the senescence of ...
Zhentao Zhang, Gabriella Shayani, Yanping Xu, Ashley Kim, Yurim Hong, Haiyue Feng, Hua Zhu   +6 more
doaj   +2 more sources

Cardiac fibroblasts: answering the call. [PDF]

Am J Physiol Heart Circ Physiol
Cardiac fibroblasts play a pivotal role in maintaining heart homeostasis by depositing extracellular matrix (ECM) to provide structural support for the myocardium, vasculature, and neuronal network and by contributing to essential physiological processes.
Kleinbongard P, Senyo SE, Lindsey ML, Garvin AM, Simpson JA, de Castro Braz LE.   +5 more
europepmc   +3 more sources

Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens [PDF]

Nature Communications
Cardiac fibrosis is mediated by the persistent activity of myofibroblasts, which differentiates from resident cardiac fibroblasts in response to tissue damage and stress signals.
Laura Pilar Aguado-Alvaro, Nerea Garitano, Wolfgang Esser-Skala, Judy Sayers, Cynthia del Valle, Daniel Alameda, Julen Mendieta-Esteban, Maria Erendira Calleja-Cervantes, Ainhoa Goñi-Salaverri, Jon Zazpe, Anna Rosaria de Vito, Francesco Marchese, Diego Alignani, Juliana Cudini, Torsten Gross, Gregorio Rábago, Nisha Narayan, Laura Martinez, Sonia Martinez, Brian Huntly, Paul Riley, Arantxa Gonzalez, Jake P. Taylor-King, Nikolaus Fortelny, Beatriz Pelacho, David Lara-Astiaso   +25 more
doaj   +2 more sources

Unique patterns of cardiogenic and fibrotic gene expression in rat cardiac fibroblasts [PDF]

Veterinary World, 2020
Background and Aim: Cardiac fibroblasts are important for both normal and pathological states of the heart, but the knowledge in cell physiology and genomics is still poorly understood.
Kittipong Tachampa, Tuempong Wongtawan
doaj   +1 more source

Cardiac Fibroblasts and Myocardial Regeneration [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
The billions of cardiomyocytes lost to acute myocardial infarction (MI) cannot be replaced by the limited regenerative capacity of adult mammalian hearts, and despite decades of research, there are still no clinically effective therapies for remuscularizing and restoring damaged myocardial tissue.
Wangping Chen, Wangping Chen, Weihua Bian, Yang Zhou, Jianyi Zhang   +4 more
openaire   +3 more sources

Activin A Secreted From Peripheral Nerve Fibroblasts Promotes Proliferation and Migration of Schwann Cells

Frontiers in Molecular Neuroscience, 2022
The peripheral nervous system has remarkable regenerative capabilities. Schwann cells and fibroblasts are known to play crucial roles in these processes.
Yan Li, Yan Li, Zhenghang Cheng, Fanhui Yu, Qi Zhang, Shu Yu, Fei Ding, Qianru He   +7 more
doaj   +1 more source

Isolation and Culture of Primary Fibroblasts from Neonatal Murine Hearts to Study Cardiac Fibrosis

Bio-Protocol, 2023
Cardiac fibroblasts are one of the major constituents of a healthy heart. Cultured cardiac fibroblasts are a crucial resource for conducting studies on cardiac fibrosis. The existing methods for culturing cardiac fibroblasts involve complicated steps and
Shweta Kumar, Dimple Nagesh, Venketsubbu Ramasubbu, Arathi Prabhashankar, Nagalingam Ravi Sundaresan   +4 more
doaj   +1 more source