Results 21 to 30 of about 928,242 (288)

Mechanical regulation of cardiac fibroblasts. [PDF]

, 2022
Cardiac fibrosis progressively contributes to heart failure (HF). Yet, its complex nature still lacks a more comprehensive understanding. One main hurdle is the lack of representative human models providing insights into the behaviour of cardiac fibroblasts (CF) and their pathological derivatives.
Santos, Gabriela Leão, Lutz, Susanne, Lutz, Susanne, Georg-August-Universität Göttingen, Schu, Peter, Dressel, Ralf, Meyer, Thomas, Katschinski, Dörthe, Zeisberg, Michael   +8 more
openaire   +2 more sources

Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts. [PDF]

PLoS ONE, 2013
Differentiation of cardiac fibroblasts into myofibroblasts is a critical event in the progression of cardiac fibrosis that leads to pathological cardiac remodeling.
Jian Bai, Na Zhang, Ying Hua, Bingjian Wang, Lin Ling, Albert Ferro, Biao Xu   +6 more
doaj   +1 more source

Emerging role of transient receptor potential (TRP) ion channels in cardiac fibroblast pathophysiology

Frontiers in Physiology, 2022
Cardiac fibroblasts make up a major proportion of non-excitable cells in the heart and contribute to the cardiac structural integrity and maintenance of the extracellular matrix.
Asfree Gwanyanya, Kanigula Mubagwa, Kanigula Mubagwa   +2 more
doaj   +1 more source

Direct Reprogramming of Cardiac Fibroblasts to Repair the Injured Heart [PDF]

, 2021
Coronary heart disease is a leading cause of mortality and morbidity. Those that survive acute myocardial infarction are at significant risk of subsequent heart failure due to fibrotic remodelling of the infarcted myocardium.
Rachel McCloy, Dykes, IM, Falconer, K, Jordan, A, Emma Adams, Ashley Jordan, Iain M. Dykes, Adams, E, Kaitlin Falconer, McCloy, R   +9 more
core   +1 more source

Inhibition of Wdr5 Attenuates Ang-II-Induced Fibroblast-to-Myofibroblast Transition in Cardiac Fibrosis by Regulating Mdm2/P53/P21 Pathway

Biomolecules, 2022
Cardiac fibrosis is an important pathological process in many diseases. Wdr5 catalyzes the trimethylation of lysine K4 on histone H3. The effects of Wdr5 on the cardiac fibrosis phenotype and the activation or transformation of cardiac fibroblasts were ...
Jiali Yuan, Hong Peng, Binfeng Mo, Chengye Yin, Guojian Fang, Yingze Li, Yuepeng Wang, Renhua Chen, Qunshan Wang   +8 more
doaj   +1 more source

The landscape of accessible chromatin in quiescent cardiac fibroblasts and cardiac fibroblasts activated after myocardial infarction [PDF]

, 2021
After myocardial infarction, the massive death of cardiomyocytes leads to cardiac fibroblast proliferation and myofibroblast differentiation, which contributes to the extracellular matrix remodelling of the infarcted myocardium.
Ming, Hao, Fu, Xing, Sun, Jiangwen, Li, Yuxia, Dodlapati, Sanjeeva, Li, Rui, Francis, Joseph, Jiang, Zongliang, Li, Chaoyang, Liu, Qianglin, Wang, Leshan   +10 more
core   +2 more sources

Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts [PDF]

, 2016
Introduction Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood. The immunoregulatory adipokine leptin is detectable in
Andrew J Skelton, Todryk, Stephen M., Rowan, Andrew, Skelton, Andrew J., Skelton, Andrew J, Williams, Rachel C., Preshaw, Philip M.; id_orcid, Preshaw, Philip M, Taylor, John, Rowan, Andrew D., Skelton, Andrew, Preshaw, Philip, Taylor, John J, Taylor, John J., Todryk, Stephen, Philip M Preshaw, Todryk, Stephen M, Rachel C Williams, Stephen M Todryk, Williams, Rachel C, Andrew D Rowan, Rowan, Andrew D, John J Taylor   +22 more
core   +2 more sources

The landscape of accessible chromatin in quiescent cardiac fibroblasts and cardiac fibroblasts activated after myocardial infarction [PDF]

, 2022
After myocardial infarction, the massive death of cardiomyocytes leads to cardiac fibroblast proliferation and myofibroblast differentiation, which contributes to the extracellular matrix remodelling of the infarcted myocardium.
Ming, Hao, Sun, Jiangwen, Li, Yuxia, Dodlapati, Sanjeeva, Li, Chaoyang, Liu, Qianglin, Wang, Leshan   +6 more
core   +2 more sources

Targeting cardiac fibroblasts: The pressure is on [PDF]

Cell Cycle, 2014
Heart failure is a major health issue, with its incidence on the rise. It is well established that fibroblast accumulation in stressed myocardium causes arrhythmias and drives adverse remodeling th...
Thomas, Moore-Morris, Michel, Pucéat, Sylvia M, Evans   +2 more
openaire   +2 more sources

Novel Techniques Targeting Fibroblasts after Ischemic Heart Injury

Cells, 2022
The great plasticity of cardiac fibroblasts allows them to respond quickly to myocardial injury and to contribute to the subsequent cardiac remodeling.
Sirin N. Cakir, Kaitlin M. Whitehead, Hanifah K. L. Hendricks, Lisandra E. de Castro Brás   +3 more
doaj   +1 more source