Results 31 to 40 of about 928,242 (288)

Multiple Ca2+ signaling pathways regulate intracellular Ca 2+ activity in human cardiac fibroblasts [PDF]

, 2010
Ca2+ signaling pathways are well studied in cardiac myocytes, but not in cardiac fibroblasts. The aim of the present study is to characterize Ca2+ signaling pathways in cultured human cardiac fibroblasts using confocal scanning microscope and RT-PCR ...
Li, GR, Tse, HF, Lau, CP, Chen, JB, Tao, R, Sun, HY   +5 more
core   +1 more source

A TRP to cardiac fibroblast differentiation [PDF]

Channels, 2013
The differentiation of cardiac fibroblasts to myofibroblasts is one of the key events during cardiac remodeling, however, the molecular mechanism underlying this process is not well known. Calcium signaling plays an important role in the regulation of cardiac fibroblast function, but its role in the differentiation of fibroblasts is undefined. Recently
Charles K, Thodeti, Sailaja, Paruchuri, J Gary, Meszaros   +2 more
openaire   +2 more sources

Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts [PDF]

, 2009
Background: Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which there is no therapy. Fibroblasts from lesional areas of scleroderma patients possess elevated abilities to contract matrix ...
Christopher P Denton, Abraham, DJ, Denton, CP, Mark Eastwood, Sonali Sonnylal, Shi-Wen, X., Liu Shangxi, Leask, A., Abraham David J., Liu, SX, Shi-wen, X, Denton, C.P., Shangxi Liu, Sonnylal, S, Abraham, D.J., David J Abraham, Liu, S., Andrew Leask, Shi-wen Xu, Denton Christopher P., Eastwood Mark, Eastwood, M, Leask, A, Eastwood, M., Sonnylal Sonali, Leask Andrew, Sonnylal, S.   +26 more
core   +2 more sources

Isolation and Primary Culture of Adult Mouse Cardiac Fibroblasts

Bio-Protocol, 2016
Fibroblasts are often used as a feeder layer for progenitor or stem cells in co-culture systems. In the heart fibroblasts are important for cardiac development, homeostasis, and remodelling.
Maria Zafeiriou, Claudia Noack, Laura Zelarayan   +2 more
doaj   +1 more source

Toll-like receptor 9 mediated responses in cardiac fibroblasts. [PDF]

PLoS ONE, 2014
Altered cardiac Toll-like receptor 9 (TLR9) signaling is important in several experimental cardiovascular disorders. These studies have predominantly focused on cardiac myocytes or the heart as a whole.
Ingrid Kristine Ohm, Katrine Alfsnes, Maria Belland Olsen, Trine Ranheim, Øystein Sandanger, Tuva Børresdatter Dahl, Pål Aukrust, Alexandra Vanessa Finsen, Arne Yndestad, Leif Erik Vinge   +9 more
doaj   +1 more source

Loss of Function in Dopamine D3 Receptor Attenuates Left Ventricular Cardiac Fibroblast Migration and Proliferation in vitro

Frontiers in Cardiovascular Medicine, 2021
Evidence suggests the existence of an intracardiac dopaminergic system that plays a pivotal role in regulating cardiac function and fibrosis through G-protein coupled receptors, particularly mediated by dopamine receptor 3 (D3R).
Andrew Kisling, Shannon Byrne, Rohan U. Parekh, Deepthy Melit-Thomas, Lisandra E. de Castro Brás, Lisandra E. de Castro Brás, Robert M. Lust, Stefan Clemens, Srinivas Sriramula, Laxmansa C. Katwa   +9 more
doaj   +1 more source

Defining the Cardiac Fibroblast

Circulation Journal, 2016
Cardiac fibrosis remains an important health concern, but the study of fibroblast biology has been hindered by a lack of effective means for identifying and tracking fibroblasts. Recent advances in fibroblast-specific lineage tags and reporters have permitted a better understanding of these cells.
Ivey, Malina J., Tallquist, Michelle D.
openaire   +3 more sources

Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion [PDF]

, 2019
Piezo1 is a mechanosensitive cation channel with widespread physiological importance; however, its role in the heart is poorly understood. Cardiac fibroblasts help preserve myocardial integrity and play a key role in regulating its repair and remodeling ...
Stylianidis, Vasili, Beech, David J., Gilbert, Hamish TJ, Drinkhill, Mark J., Swift, J, Li, J, Evans, EL, Cuthbertson, K, Evans, Elizabeth L, Turner, Neil A, van Nieuwenhoven, Frans A., Beech, DJ, Drinkhill, MJ, Porter, Karen E, Porter, Karen E., Gilbert, Hamish T.J., Gilbert, Hamish T. J., Ludlow, MJ, Blythe, NM, Gilbert, Hamish T J, Ludlow, Melanie J., Beech, David J, van Nieuwenhoven, FA, Stylianidis, V, Blythe, Nicola M, Drinkhill, Mark J, Foster, Richard, Li, Jing, Ludlow, Melanie J, Cuthbertson, Kevin, Turner, Neil A., Gilbert, HTJ, Porter, KE, Muraki, Katsuhiko, Blythe, Nicola M., Evans, Elizabeth L., Turner, NA, van Nieuwenhoven, Frans A, Swift, Joe; id_orcid, Foster, R, Muraki, K, Swift, Joe   +41 more
core   +1 more source

Redefining the identity of cardiac fibroblasts [PDF]

Nature Reviews Cardiology, 2017
Cardiac fibroblasts deposit and maintain extracellular matrix during organogenesis and under physiological conditions. In the adult heart, activated cardiac fibroblasts also participate in the healing response after acute myocardial infarction and during chronic disease states characterized by augmented interstitial fibrosis and ventricular remodelling.
Michelle D, Tallquist, Jeffery D, Molkentin   +1 more
openaire   +2 more sources

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics [PDF]

, 2016
Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that ...
van Laar, Jacob, Van Laar, Jacob M., O'Reilly, Steven, Fullard, Nicola, Ciechomska, Marzena, Przyborski, Stefan, van Laar, J.M., O’Reilly, S., Fullard, N., Przyborski, S., Ciechomska, M.   +10 more
core   +2 more sources