Results 11 to 20 of about 928,242 (288)

Origins of cardiac fibroblasts [PDF]

Journal of Molecular and Cellular Cardiology, 2016
Cardiac fibroblasts produce the extracellular matrix (ECM) scaffold within which the various cellular components of the heart are organized. As well as providing structural support, it is becoming evident that the quality and quantity of ECM is a key factor for determining cardiac cell behavior during development and in pathological contexts such as ...
Moore-Morris T., Cattaneo P., Puceat M., Evans S. M.   +3 more
openaire   +5 more sources

REV-ERB is essential in cardiac fibroblasts homeostasis [PDF]

Frontiers in Pharmacology, 2022
REV-ERB agonists have shown antifibrotic effects in the heart and other organs. The function of REV-ERB in the cardiac fibroblasts remains unstudied. Here, we characterize the functional difference of REV-ERB in mouse embryonic fibroblasts and cardiac ...
Xiaokang Luo, Shiyang Song, Lei Qi, Chih-Liang Tien, Hui Li, Weiyi Xu, Theodore Lemuel Mathuram, Thomas Burris, Yuanbiao Zhao, Zheng Sun, Zheng Sun, Lilei Zhang   +11 more
doaj   +2 more sources

Cardiac fibroblasts support cardiac inflammation in heart failure

Basic Research in Cardiology, 2014
Cardiac remodeling and inflammation are hallmarks of cardiac failure and correlate with outcome in patients. However, the basis for the development of both remains unclear. We have previously reported that cardiac inflammation triggers transdifferentiation of fibroblasts to myofibroblasts and therefore increase accumulation of cardiac collagen, one key
Lindner, Diana, Blankenberg, Stefan, Hinrichs, Svenja, Tank, Juliane, Zietsch, Christin, Sossalla, Samuel, Fluschnik, Nina, Maier, Lars S., Poller, Wolfgang, Schultheiss, Heinz‐Peter, Tschöpe, Carsten, Westermann, D.   +11 more
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Cardiac fibroblasts regulate sympathetic nerve sprouting and neurocardiac synapse stability.

PLoS ONE, 2013
Sympathetic nervous system (SNS) plays a key role in cardiac homeostasis and its deregulations always associate with bad clinical outcomes. To date, little is known about molecular mechanisms regulating cardiac sympathetic innervation.
Céline Mias, Christelle Coatrieux, Colette Denis, Gaël Genet, Marie-Hélène Seguelas, Nathalie Laplace, Charlotte Rouzaud-Laborde, Denis Calise, Angelo Parini, Daniel Cussac, Atul Pathak, Jean-Michel Sénard, Céline Galés   +12 more
doaj   +2 more sources

Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells

International Journal of Nanomedicine, 2015
Kunwoo Lee,1,2 Pengzhi Yu,3 Nithya Lingampalli,1 Hyun Jin Kim,1 Richard Tang,1 Niren Murthy1,2 1Department of Bioengineering, University of California, Berkeley, CA, USA; 2UC Berkeley and UCSF Joint Graduate Program in Bioengineering, Berkeley/San ...
Lee K, Yu P, Lingampalli N, Kim HJ, Tang R, Murthy N   +5 more
doaj   +1 more source

Impaired cardiac autonomic nervous control after cardiac bypass surgery for congenital heart disease [PDF]

, 2009
We undertook a study to describe changes in heart rate variability (HRV) postoperatively in children undergoing cardiac bypass surgery for congenital heart disease (CHD).
McGlone, Laura, Financial Support Department of Cardiac Surgery and Cardiology, The Royal Hospital for Sick Children, Yorkhill, Glasgow (Funder), Patel, Neil, Danton, Mark D., , Financial Support Department of Cardiac Surgery and Cardiology,, Young, David   +5 more
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Peripheral nerve fibroblasts secrete neurotrophic factors to promote axon growth of motoneurons

Neural Regeneration Research, 2022
Peripheral nerve fibroblasts play a critical role in nerve development and regeneration. Our previous study found that peripheral nerve fibroblasts have different sensory and motor phenotypes.
Qian-Ru He, Meng Cong, Fan-Hui Yu, Yu-Hua Ji, Shu Yu, Hai-Yan Shi, Fei Ding   +6 more
doaj   +1 more source

Piezo1 Mechanosensitive Ion Channel Mediates Stretch-Induced Nppb Expression in Adult Rat Cardiac Fibroblasts

Cells, 2021
In response to stretch, cardiac tissue produces natriuretic peptides, which have been suggested to have beneficial effects in heart failure patients.
Meike C. Ploeg, Chantal Munts, Frits W. Prinzen, Neil A. Turner, Marc van Bilsen, Frans A. van Nieuwenhoven   +5 more
doaj   +1 more source

Conservation of miR combo based direct cardiac reprogramming

Biochemistry and Biophysics Reports, 2022
There is considerable interest in regenerating the injured heart by reprogramming resident fibroblasts into new functional cardiomyocytes. Cardiac reprogramming has been achieved via transcription factors or miRNAs.
Syeda Samara Baksh, Conrad P. Hodgkinson
doaj   +1 more source

Cardiac Fibroblast [PDF]

Circulation Research, 2009
The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes, endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated that there are undulating changes in cardiac cell populations during embryonic development, through neonatal development and into the adult.
Colby A, Souders, Stephanie L K, Bowers, Troy A, Baudino   +2 more
openaire   +2 more sources