Results 41 to 50 of about 928,242 (288)

Doxorubicin-induced p53 interferes with mitophagy in cardiac fibroblasts.

PLoS ONE, 2020
Anthracyclines are the critical component in a majority of pediatric chemotherapy regimens due to their broad anticancer efficacy. Unfortunately, the vast majority of long-term childhood cancer survivors will develop a chronic health condition caused by ...
T R Mancilla, L R Davis, G J Aune
doaj   +1 more source

Cardiac fibroblasts [PDF]

Herzschrittmachertherapie + Elektrophysiologie, 2018
Fibrotic areas in cardiac muscle-be it in ventricular or atrial tissue-are considered as obstacles for conduction of the excitatory wave and can therefore facilitate re-entry, which may contribute to the sustenance of cardiac arrhythmias. Persistence of one of the most frequent arrhythmias, atrial fibrillation (AF), is accompanied by enhanced atrial ...
Klesen, Alexander, Jakob, Dorothee Ruth, Emig, Ramona, Kohl, Peter, Ravens, Ursula, Peyronnet, Remi   +5 more
openaire   +3 more sources

Mechanotransduction in fibroblasts [PDF]

, 2011
Response to mechanical stress is important for tissue homeostasis, tissue architecture and muscle regeneration. All cells of an organism are subject to at least one of three types of mechanical stress: compression, shear stress or tension.
Brosig, Michaela
core   +1 more source

Hypoxic Stress Induces Transient Receptor Potential Melastatin 2 (TRPM2) Channel Expression in Adult Rat Cardiac Fibroblasts

Journal of Pharmacological Sciences, 2012
When cardiac tissue is exposed to hypoxia, myocytes are damaged, while fibroblasts are activated. However, it is unknown what changes are induced by hypoxia in cardiac fibroblasts.
Kenji Takahashi, Kazuho Sakamoto, Junko Kimura   +2 more
doaj   +1 more source

CREG ameliorates the phenotypic switching of cardiac fibroblasts after myocardial infarction via modulation of CDC42

Cell Death and Disease, 2021
Phenotype switching of cardiac fibroblasts into myofibroblasts plays important role in cardiac fibrosis following myocardial infarction (MI). Cellular repressor of E1A-stimulated genes (CREG) protects against vascular and cardiac remodeling induced by ...
Dan Liu, Xiaoxiang Tian, Yanxia Liu, Haixu Song, Xiaoli Cheng, Xiaolin Zhang, Chenghui Yan, Yaling Han   +7 more
doaj   +1 more source

Single-cell analysis reveals lysyl oxidase (Lox)+ fibroblast subset involved in cardiac fibrosis of diabetic mice

Journal of Advanced Research, 2023
Introduction: Myocardial fibrosis and cardiac dysfunction are the main characteristics of diabetic heart disease. However, the molecular mechanisms underlying diabetic myocardial fibrosis remain unclear.
Heyangzi Li, Xiaoqing Zhu, Xi Cao, Yicheng Lu, Jianwei Zhou, Xiaoming Zhang   +5 more
doaj   +1 more source

Inflammatory activation of human cardiac fibroblasts leads to altered calcium signaling, decreased connexin 43 expression and increased glutamate secretion

Heliyon, 2017
Cardiac fibroblasts, which are abundant in heart tissue, are involved not only in extracellular matrix homeostasis and repair, but also in cardiac remodeling after a myocardial infarction that, in turn, can lead to loss of cardiac function and heart ...
Eva Skiöldebrand, Annika Lundqvist, Ulrika Björklund, Mikael Sandstedt, Anders Lindahl, Elisabeth Hansson, Lillemor Mattsson Hultén   +6 more
doaj   +1 more source

Primary skin fibroblasts as a model of Parkinson's disease [PDF]

, 2012
Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease.
Morales-Gordo, B., Jendrach, M., Heinz Reichmann, Brandt, Ulrich, Reichmann, H., Michael Klinkenberg, Jessica Drost, Morales-Gordo, Blas, Auburger, Georg, Blas Morales-Gordo, Vania Broccoli, Brandt, U., Marina Jendrach, Marcus, K., Klinkenberg, Michael, Auburger, G., Gispert, Suzana, Broccoli, Vania, Suzana Gispert, Marcus, Katrin, Ulrich Brandt, Jendrach, Marina, Wolfram S. Kunz, Klinkenberg, M., Drost, Jessica, Georg Auburger, Kunz, Wolfram S., Gispert, S., Kunz, W.S., Katrin Marcus, Droste, J.A.H., Broccoli, V., Reichmann, Heinz   +32 more
core   +1 more source

3D Cell Migration Studies for Chemotaxis on Microfluidic-Based Chips: A Comparison between Cardiac and Dermal Fibroblasts

Bioengineering, 2018
Fibroblast migration to damaged zones in different tissues is crucial to regenerate and recuperate their functional activity. However, fibroblast migration patterns have hardly been studied in disease terms.
Sandra Pérez-Rodríguez, Esther Tomás-González, José Manuel García-Aznar   +2 more
doaj   +1 more source

Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators

Acta Pharmaceutica Sinica B, 2020
Overexpression of exogenous lineage-determining factors succeeds in directly reprogramming fibroblasts to various cell types. Several studies have reported reprogramming of fibroblasts into induced cardiac progenitor cells (iCPCs).
Jianglin Wang, Xueyan Jiang, Lixin Zhao, Shengjia Zuo, Xiantong Chen, Lingmin Zhang, Zhongxiao Lin, Xiaoya Zhao, Yuyan Qin, Xinke Zhou, Xi-Yong Yu   +10 more
doaj   +1 more source