Results 21 to 30 of about 862,015 (296)

Toll-like receptor 9 mediated responses in cardiac fibroblasts. [PDF]

PLoS ONE, 2014
Altered cardiac Toll-like receptor 9 (TLR9) signaling is important in several experimental cardiovascular disorders. These studies have predominantly focused on cardiac myocytes or the heart as a whole.
Ingrid Kristine Ohm, Katrine Alfsnes, Maria Belland Olsen, Trine Ranheim, Øystein Sandanger, Tuva Børresdatter Dahl, Pål Aukrust, Alexandra Vanessa Finsen, Arne Yndestad, Leif Erik Vinge   +9 more
doaj   +1 more source

Loss of Function in Dopamine D3 Receptor Attenuates Left Ventricular Cardiac Fibroblast Migration and Proliferation in vitro

Frontiers in Cardiovascular Medicine, 2021
Evidence suggests the existence of an intracardiac dopaminergic system that plays a pivotal role in regulating cardiac function and fibrosis through G-protein coupled receptors, particularly mediated by dopamine receptor 3 (D3R).
Andrew Kisling, Shannon Byrne, Rohan U. Parekh, Deepthy Melit-Thomas, Lisandra E. de Castro Brás, Lisandra E. de Castro Brás, Robert M. Lust, Stefan Clemens, Srinivas Sriramula, Laxmansa C. Katwa   +9 more
doaj   +1 more source

Novel Techniques Targeting Fibroblasts after Ischemic Heart Injury

Cells, 2022
The great plasticity of cardiac fibroblasts allows them to respond quickly to myocardial injury and to contribute to the subsequent cardiac remodeling.
Sirin N. Cakir, Kaitlin M. Whitehead, Hanifah K. L. Hendricks, Lisandra E. de Castro Brás   +3 more
doaj   +1 more source

Long noncoding RNA Cfast regulates cardiac fibrosis

Molecular Therapy: Nucleic Acids, 2021
Cardiac fibrosis occurs in most cardiac diseases, which reduces cardiac muscle compliance, impairs both systolic and diastolic heart function and, ultimately, leads to heart failure.
Feng Zhang, Xuyang Fu, Masaharu Kataoka, Ning Liu, Yingchao Wang, Feng Gao, Tian Liang, Xiaoxuan Dong, Jianqiu Pei, Xiaoyun Hu, Wei Zhu, Hong Yu, Douglas B. Cowan, Xinyang Hu, Zhan-Peng Huang, Jian’an Wang, Da-Zhi Wang, Jinghai Chen   +17 more
doaj   +1 more source

Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts [PDF]

, 2014
Aims: Fibroblast growth factor 21 (FGF21) is a hepatic metabolic regulator with pleotropic actions. Its plasma concentrations are increased in obesity and diabetes; states associated with an increased incidence of cardiovascular disease.
Muhammad F Bari, Bari Muhammad F., Jing Chen, Edward W. Hillhouse (519261), Bari, Muhammad F., Raghu Adya (519258), Patel Vanlata, Bhudia, Sunil K., Edward W Hillhouse, Harpal S Randeva, Vanlata Patel, Raghu Adya, Chen Jing, Manjunath Ramanjaneya, Bee K. Tan (417731), Ramanjaneya, Manjunath, Jing Chen (4762), Patel, Vanlata H., Ramanjaneya Manjunath, Harpal S. Randeva (417734), Randeva Harpal S., Muhammad F. Bari (417733), Tan, Bee K., Adya Raghu, Adya, Raghu, Tan Bee K., Bhudia Sunil K., Randeva, Harpal S., Bee K Tan, Manjunath Ramanjaneya (519259), Sunil K Bhudia, Sunil K. Bhudia (519260), Hillhouse Edward W., Vanlata Patel (519257), Hillhouse, Edward W., Chen, Jing   +35 more
core   +1 more source

Targeting cardiac fibroblasts: The pressure is on [PDF]

Cell Cycle, 2014
Heart failure is a major health issue, with its incidence on the rise. It is well established that fibroblast accumulation in stressed myocardium causes arrhythmias and drives adverse remodeling th...
Thomas, Moore-Morris, Michel, Pucéat, Sylvia M, Evans   +2 more
openaire   +2 more sources

Cardiac Cell Patterning on Customized Microelectrode Arrays for Electrophysiological Recordings

Micromachines, 2021
Cardiomyocytes (CMs) and fibroblast cells are two essential elements for cardiac tissue structure and function. The interactions between them can alter cardiac electrophysiology and thus contribute to cardiac diseases, such as arrhythmogenesis.
Jiaying Ji, Xiang Ren, Pinar Zorlutuna
doaj   +1 more source

Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes.
Caitlin Hall, Katja Gehmlich, Chris Denning, Davor Pavlovic   +3 more
doaj   +1 more source

A TRP to cardiac fibroblast differentiation [PDF]

Channels, 2013
The differentiation of cardiac fibroblasts to myofibroblasts is one of the key events during cardiac remodeling, however, the molecular mechanism underlying this process is not well known. Calcium signaling plays an important role in the regulation of cardiac fibroblast function, but its role in the differentiation of fibroblasts is undefined. Recently
Charles K, Thodeti, Sailaja, Paruchuri, J Gary, Meszaros   +2 more
openaire   +2 more sources

Cardiac fibroblast heat shock protein 47 aggravates cardiac fibrosis post myocardial ischemia–reperfusion injury by encouraging ubiquitin specific peptidase 10 dependent Smad4 deubiquitination

Acta Pharmaceutica Sinica B, 2022
Despite complications were significantly reduced due to the popularity of percutaneous coronary intervention (PCI) in clinical trials, reperfusion injury and chronic cardiac remodeling significantly contribute to poor prognosis and rehabilitation in AMI ...
Saiyang Xie, Yun Xing, Wenke Shi, Min Zhang, Mengya Chen, Wenxi Fang, Shiqiang Liu, Tong Zhang, Xiaofeng Zeng, Si Chen, Shasha Wang, Wei Deng, Qizhu Tang   +12 more
doaj   +1 more source