Results 11 to 20 of about 862,015 (296)

Regulation of Cardiac Fibroblast GLS1 Expression by Scleraxis

Cells, 2022
Fibrosis is an energy-intensive process requiring the activation of fibroblasts to myofibroblasts, resulting in the increased synthesis of extracellular matrix proteins.
Sikta Chattopadhyaya, Raghu S. Nagalingam, D. Allison Ledingham, Teri L. Moffatt, Danah S. Al-Hattab, Pavit Narhan, Matthew T. Stecy, Kimberley A. O’Hara, Michael P. Czubryt   +8 more
doaj   +2 more sources

Fibroblast-specific IKK-β deficiency ameliorates angiotensin II–induced adverse cardiac remodeling in mice [PDF]

JCI Insight, 2021
Cardiac inflammation and fibrosis contribute significantly to hypertension-related adverse cardiac remodeling. IκB kinase β (IKK-β), a central coordinator of inflammation through activation of NF-κB, has been demonstrated as a key molecular link between ...
Weiwei Lu, Zhaojie Meng, Rebecca Hernandez, Changcheng Zhou   +3 more
doaj   +2 more sources

Impaired cardiac autonomic nervous control after cardiac bypass surgery for congenital heart disease [PDF]

, 2009
We undertook a study to describe changes in heart rate variability (HRV) postoperatively in children undergoing cardiac bypass surgery for congenital heart disease (CHD).
McGlone, Laura, Financial Support Department of Cardiac Surgery and Cardiology, The Royal Hospital for Sick Children, Yorkhill, Glasgow (Funder), Patel, Neil, Danton, Mark D., , Financial Support Department of Cardiac Surgery and Cardiology,, Young, David   +5 more
core   +4 more sources

Cardiac Fibroblasts and Myocardial Regeneration [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
The billions of cardiomyocytes lost to acute myocardial infarction (MI) cannot be replaced by the limited regenerative capacity of adult mammalian hearts, and despite decades of research, there are still no clinically effective therapies for remuscularizing and restoring damaged myocardial tissue.
Wangping Chen, Wangping Chen, Weihua Bian, Yang Zhou, Jianyi Zhang   +4 more
openaire   +3 more sources

Cardiac Fibrosis and Fibroblasts [PDF]

Cells, 2021
Cardiac fibrosis is the excess deposition of extracellular matrix (ECM), such as collagen. Myofibroblasts are major players in the production of collagen, and are differentiated primarily from resident fibroblasts. Collagen can compensate for the dead cells produced by injury.
openaire   +3 more sources

Origins of Cardiac Fibroblasts [PDF]

Circulation Research, 2010
Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions, cardiac fibroblasts remain poorly characterized in molecular terms.
Zeisberg, Elisabeth M., Kalluri, Raghu
openaire   +3 more sources

Origins of cardiac fibroblasts [PDF]

Journal of Molecular and Cellular Cardiology, 2016
Cardiac fibroblasts produce the extracellular matrix (ECM) scaffold within which the various cellular components of the heart are organized. As well as providing structural support, it is becoming evident that the quality and quantity of ECM is a key factor for determining cardiac cell behavior during development and in pathological contexts such as ...
Moore-Morris T., Cattaneo P., Puceat M., Evans S. M.   +3 more
openaire   +3 more sources

Cardiomyocyte intercellular signalling increases oxidative stress and reprograms the global‐ and phospho‐proteome of cardiac fibroblasts

Journal of Extracellular Biology, 2023
Pathological reprogramming of cardiomyocyte and fibroblast proteome landscapes drive the initiation and progression of cardiac fibrosis. Although the secretome of dysfunctional cardiomyocytes is emerging as an important driver of pathological fibroblast ...
Bethany Claridge, Alin Rai, Jarmon G. Lees, Haoyun Fang, Shiang Y. Lim, David W. Greening   +5 more
doaj   +1 more source

SerpinA3 is an Endogenous TGF-β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling. [PDF]

Adv Sci (Weinh)
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Wang H, Cui J, Huang C, Guo W, Liu T, Zhu Y, Shao S, Chen K, He J, Bao Q.   +9 more
europepmc   +2 more sources

Mechanical regulation of cardiac fibroblasts. [PDF]

, 2022
Cardiac fibrosis progressively contributes to heart failure (HF). Yet, its complex nature still lacks a more comprehensive understanding. One main hurdle is the lack of representative human models providing insights into the behaviour of cardiac fibroblasts (CF) and their pathological derivatives.
Santos, Gabriela Leão, Lutz, Susanne, Lutz, Susanne, Georg-August-Universität Göttingen, Schu, Peter, Dressel, Ralf, Meyer, Thomas, Katschinski, Dörthe, Zeisberg, Michael   +8 more
openaire   +2 more sources