Results 41 to 50 of about 862,015 (296)

CARFMAP: A Curated Pathway Map of Cardiac Fibroblasts.

PLoS ONE, 2015
The adult mammalian heart contains multiple cell types that work in unison under tightly regulated conditions to maintain homeostasis. Cardiac fibroblasts are a significant and unique population of non-muscle cells in the heart that have recently gained ...
Hieu T Nim, Milena B Furtado, Mauro W Costa, Hiroaki Kitano, Nadia A Rosenthal, Sarah E Boyd   +5 more
doaj   +1 more source

Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1

Redox Biology
Cardiac fibrosis remains an unresolved clinical issue in patients with heart diseases. CircRNAs have emerged as potential targets for treatment of heart diseases.
Yan Chen, Zhewei Zhang, Yue Cheng, Xiaofeng Chen, Junteng Zhou, Zisong Wei, Han Yao, Shuwen Zhang, Qihang Kong, Hao Tang, Wenchao Wu, Zhichao Zhou, Xiaoqiang Tang, Xiaojing Liu   +13 more
doaj   +1 more source

In vitro effects of pirfenidone on cardiac fibroblasts: proliferation, myofibroblast differentiation, migration and cytokine secretion.

PLoS ONE, 2011
Cardiac fibroblasts (CFs) are the primary cell type responsible for cardiac fibrosis during pathological myocardial remodeling. Several studies have illustrated that pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) attenuates cardiac fibrosis in different
Qiang Shi, Xiaoyan Liu, Yuanyuan Bai, Chuanjue Cui, Jun Li, Yishi Li, Shengshou Hu, Yingjie Wei   +7 more
doaj   +1 more source

Anti-fibrotic Effects of Cardiac Progenitor Cells in a 3D-Model of Human Cardiac Fibrosis

Frontiers in Cardiovascular Medicine, 2019
Cardiac fibroblasts play a key role in chronic heart failure. The conversion from cardiac fibroblast to myofibroblast as a result of cardiac injury, will lead to excessive matrix deposition and a perpetuation of pro-fibrotic signaling.
Tom C. L. Bracco Gartner, Tom C. L. Bracco Gartner, Tom C. L. Bracco Gartner, Tom C. L. Bracco Gartner, Janine C. Deddens, Janine C. Deddens, Emma A. Mol, Emma A. Mol, Marina Magin Ferrer, Linda W. van Laake, Linda W. van Laake, Linda W. van Laake, Carlijn V. C. Bouten, Ali Khademhosseini, Pieter A. Doevendans, Pieter A. Doevendans, Pieter A. Doevendans, Pieter A. Doevendans, Pieter A. Doevendans, Pieter A. Doevendans, Willem J. L. Suyker, Willem J. L. Suyker, Willem J. L. Suyker, Joost P. G. Sluijter, Joost P. G. Sluijter, Joost P. G. Sluijter, Jesper Hjortnaes, Jesper Hjortnaes, Jesper Hjortnaes   +28 more
doaj   +1 more source

Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis

eLife, 2020
Intermittent hypoxia (IH) is the predominant pathophysiological disturbance in obstructive sleep apnea (OSA), known to be independently associated with cardiovascular diseases.
Qiankun Bao, Bangying Zhang, Ya Suo, Chen Liu, Qian Yang, Kai Zhang, Ming Yuan, Meng Yuan, Yue Zhang, Guangping Li   +9 more
doaj   +1 more source

Shh-stimulated cardiac fibroblast signaling.

, 2013
Near-confluent cardiac fibroblasts were incubated with Shh, free or in the coacervate, and growth factor levels in the conditioned media were assessed after 6, 12, 24, and 48 h. Data is presented as a fold-change from the stimulation media (C).
Yadong Wang (82064), Noah Ray Johnson (412357)   +1 more
core   +1 more source

Defining the Developmental Signals of the Cardiac Fibroblast [PDF]

, 2012
Cardiac fibroblasts play a central role as a mediator of inflammatory and fibrotic response and also secrete extracellular matrix components that provide structural support for regeneration and remodeling of the wound.
Baek, Seung Tae
core   +2 more sources

Cardiac (myo)fibroblast: Novel Strategies for its Targeting Following Myocardial Infarction

, 2014
Following myocardial infarction (MI), a dynamic and complex process called wound healing is initiated, aiming to produce a robust scar and limit adverse remodeling of the left ventricle (LV).
Hermans, Kevin C. M., Blankesteijn, Matthijs, Daskalopoulos, Evangelos P.   +2 more
core   +1 more source

Ciclopirox Inhibition of eIF5A Hypusination Attenuates Fibroblast Activation and Cardiac Fibrosis

, 2023
Cardiac fibrosis is a primary contributor to heart failure (HF), and is considered to be a targetable process for HF therapy. Cardiac fibroblast (CF) activation accompanied by excessive extracellular matrix (ECM) production is central to the initiation ...
Kadiam C. Venkata Subbaiah, Jiangbin Wu, Peng Yao, Wai Hong Wilson Tang   +3 more
core   +1 more source

Silencing of UTX Mitigates Aging-Associated Cardiac Fibrosis via Blocking Cardiac Fibro blaststo-Myofibroblasts Trans-Differentiation

Anatolian Journal of Cardiology, 2023
Background: Cardiac fibrosis increases with age. Fibroblast activation plays an essential role in cardiac fibrosis. Histone modifications are involved in various chromatin-dependent processes.
Chao Li, Tiantian Lin, Delin Li, Daoyuan Si, Huan Sun, Sibao Yang, Zhongfan Zhang, Qian Zhang, Kaiyao Shi   +8 more
doaj   +1 more source