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Biology Direct, 2022 Background Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetes. However, the underlying mechanisms of cardiac fibrosis remain unclear.
Tingwei Peng +12 more
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Electrophysiological Consequences of Cardiac Fibrosis [PDF]
Cells, 2021 For both the atria and ventricles, fibrosis is generally recognized as one of the key determinants of conduction disturbances. By definition, fibrosis refers to an increased amount of fibrous tissue. However, fibrosis is not a singular entity. Various forms can be distinguished, that differ in distribution: replacement fibrosis, endomysial and ...
Sander Verheule, Ulrich Schotten
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Modulation of Cardiac Fibrosis in and Beyond Cells
Frontiers in Molecular Biosciences, 2021 The extracellular matrix (ECM) plays important roles in maintaining physiological structure and functions of various tissues and organs. Cardiac fibrosis is the excess deposition of ECM, including both fibrillar (collagens I and III) and non-fibrillar ...
Dong Fan, Zamaneh Kassiri
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A Review of CXCL1 in Cardiac Fibrosis [PDF]
Frontiers in Cardiovascular Medicine, 2021 Chemokine C-X-C motif ligand-1 (CXCL1), principally expressed in neutrophils, macrophages and epithelial cells, is a valid pro-inflammatory factor which performs an important role in mediating the infiltration of neutrophils and monocytes/macrophages. Elevated serum level of CXCL1 is considered a pro-inflammatory reaction by the organism. CXCL1 is also
Cheng-Long Wu +3 more
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ADAMTS8 Promotes Cardiac Fibrosis Partly Through Activating EGFR Dependent Pathway
Frontiers in Cardiovascular Medicine, 2022 Myocardial infarction or pressure overload leads to cardiac fibrosis, the leading cause of heart failure. ADAMTS8 (A disintegrin and metalloproteinase with thrombospondin motifs 8) has been reported to be involved in many fibrosis-related diseases ...
Yafang Zha +6 more
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TRPC3 Channels in Cardiac Fibrosis [PDF]
Frontiers in Cardiovascular Medicine, 2017 Cardiac stiffness, caused by interstitial fibrosis due to deposition of extracellular matrix proteins, is thought as a major clinical outcome of heart failure with preserved ejection fraction (HFpEF). Canonical transient receptor potential (TRPC) subfamily proteins are components of Ca2+-permeable non-selective cation channels activated by receptor ...
Takuro Numaga-Tomita +12 more
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Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect
, 2023 Cardiac fibrosis is a pathological condition characterized by excessive deposition of collagen and other extracellular matrix components in the heart. It is recognized as a major contributor to the development and progression of heart failure.
Abdul Majid +4 more
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Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]
, 2009 Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Smith, Godfrey +12 more
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Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis. [PDF]
PLoS ONE, 2016 Cardiac fibrosis attributed to excessive deposition of extracellular matrix proteins is a major cause of heart failure and death. Cardiac fibrosis is extremely difficult and challenging to treat in a clinical setting due to lack of understanding of ...
Jody Groenendyk +6 more
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LncRNA CFRL aggravates cardiac fibrosis by modulating both miR-3113-5p/CTGF and miR-3473d/FN1 axis
iScience, 2023 Summary: Cardiac fibrosis is a major type of adverse remodeling, predisposing the disease progression to ultimate heart failure. However, the complexity of pathogenesis has hampered the development of therapies.
Yue Cui +9 more
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