Results 21 to 30 of about 215,781 (262)
Electrophysiological Consequences of Cardiac Fibrosis [PDF]
Cells, 2021 For both the atria and ventricles, fibrosis is generally recognized as one of the key determinants of conduction disturbances. By definition, fibrosis refers to an increased amount of fibrous tissue. However, fibrosis is not a singular entity. Various forms can be distinguished, that differ in distribution: replacement fibrosis, endomysial and ...
Sander Verheule, Ulrich Schotten
openaire +4 more sources
Frontiers in Pharmacology, 2020 Rationale: Cardiac fibrosis is observed in nearly every form of myocardial disease. Long non-coding RNAs (lncRNAs) have been shown to play an important role in cardiac fibrosis, but the detailed molecular mechanism remains unknown.Object: We aimed at ...
Bihui Luo +9 more
doaj +1 more source
A Review of CXCL1 in Cardiac Fibrosis [PDF]
Frontiers in Cardiovascular Medicine, 2021 Chemokine C-X-C motif ligand-1 (CXCL1), principally expressed in neutrophils, macrophages and epithelial cells, is a valid pro-inflammatory factor which performs an important role in mediating the infiltration of neutrophils and monocytes/macrophages. Elevated serum level of CXCL1 is considered a pro-inflammatory reaction by the organism. CXCL1 is also
Cheng-Long Wu +3 more
openaire +3 more sources
Modulation of Cardiac Fibrosis in and Beyond Cells
Frontiers in Molecular Biosciences, 2021 The extracellular matrix (ECM) plays important roles in maintaining physiological structure and functions of various tissues and organs. Cardiac fibrosis is the excess deposition of ECM, including both fibrillar (collagens I and III) and non-fibrillar ...
Dong Fan, Zamaneh Kassiri
doaj +1 more source
Immobilizing Interstitial Cardiac Fibrosis
Cardiology Research, 2023 The alterations in the endomysium and perimysium might cause compaction and gradual mechanical compression of cardiomyocytes resulting in their immobilization. This process finally leads to severe stiffening, so that the newly formed frame around individual cardiomyocytes and their clusters hinders normal diastole, and later systole. This phenomenon is
Yuriy L. Shevchenko +2 more
openaire +2 more sources
LncRNA CFRL aggravates cardiac fibrosis by modulating both miR-3113-5p/CTGF and miR-3473d/FN1 axis
iScience, 2023 Summary: Cardiac fibrosis is a major type of adverse remodeling, predisposing the disease progression to ultimate heart failure. However, the complexity of pathogenesis has hampered the development of therapies.
Yue Cui +9 more
doaj +1 more source
TRPC3 Channels in Cardiac Fibrosis [PDF]
Frontiers in Cardiovascular Medicine, 2017 Cardiac stiffness, caused by interstitial fibrosis due to deposition of extracellular matrix proteins, is thought as a major clinical outcome of heart failure with preserved ejection fraction (HFpEF). Canonical transient receptor potential (TRPC) subfamily proteins are components of Ca2+-permeable non-selective cation channels activated by receptor ...
Takuro Numaga-Tomita +12 more
openaire +3 more sources
Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis. [PDF]
PLoS ONE, 2016 Cardiac fibrosis attributed to excessive deposition of extracellular matrix proteins is a major cause of heart failure and death. Cardiac fibrosis is extremely difficult and challenging to treat in a clinical setting due to lack of understanding of ...
Jody Groenendyk +6 more
doaj +1 more source
Targeting GPCRs to treat cardiac fibrosis
Frontiers in Cardiovascular Medicine, 2022 Cardiac fibrosis occurs ubiquitously in ischemic heart failure, genetic cardiomyopathies, diabetes mellitus, and aging. It triggers myocardial stiffness, which impairs cardiac function, ultimately progressing to end-stage heart failure and increased ...
Hao Zhang +2 more
doaj +1 more source
Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances
Frontiers in Physiology, 2020 Cardiac fibrosis is a common pathological change associated with cardiac injuries and diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) proteins may have some protective effects in certain situations, prolonged ...
Xing Fu +4 more
doaj +1 more source