Results 21 to 30 of about 33,667 (245)

Sex Differences in Spironolactone and the Active Metabolite Canrenone Concentrations and Adherence

Biomedicines, 2022
We aim to investigate sex differences in blood concentrations of spironolactone and the active metabolite canrenone in resistant hypertension patients.
Laura E. J. Peeters, Leonardien K. Tjong, Wim J. R. Rietdijk, Teun van Gelder, Birgit C. P. Koch, Jorie Versmissen   +5 more
doaj   +1 more source

Effect of spironolactone use in pulmonary arterial hypertension – analysis from pivotal trial databases

Pulmonary Circulation, 2021
Spironolactone, a common diuretic used in the treatment of pulmonary arterial hypertension (PAH), improves cardiopulmonary hemodynamics by attenuating the adverse effects of hyperaldosteronism on endothelin type‐B receptor function within pulmonary ...
Zeenat Safdar, Eunah Cho
doaj   +1 more source

Effect of AZD9977 and spironolactone on serum potassium in heart failure with preserved or mildly reduced ejection fraction, and renal impairment: A randomized trial

Clinical and Translational Science, 2022
This phase Ib study compared the effects of AZD9977, a selective mineralocorticoid receptor modulator with predicted low hyperkalemia risk, with spironolactone on serum potassium (sK+) in patients with heart failure (HF) with preserved or mildly reduced ...
Iain B. Squire, Anders Gabrielsen, Peter J. Greasley, Linda Wernevik, Judith Hartleib‐Geschwindner, Julie Holden, Susanne Johansson, Anna Rudvik, José Sánchez, Krister Bamberg, Johanna Melin, Andrew Whittaker   +11 more
doaj   +1 more source

Improving the dissolution properties of spironolactone using liquisolid technique

Pharmaceutical and Biomedical Research, 2015
In this study the effect of liquisolid technique on the dissolution profile of spironolactone was evaluated. Different formulations of spironolactone liquisolid compacts were prepared using various amounts of non-volatile vehicles (Poly ethylene glycol ...
Jafar Akbari, Majid Saeedi, Katayoun Morteza-Semnani, Zaynab Sadeghi Ghadi, Seyed Saeed Hosseini   +4 more
doaj   +1 more source

Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2:protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension [PDF]

, 2015
INTRODUCTION: Resistant hypertension is inadequately controlled blood pressure (BP) despite treatment with at least three BP-lowering drugs. A popular hypothesis is that resistant hypertension is due to excessive Na(+)-retention, and that 'further ...
Williams, B, Caulfield, M, MacDonald, TM, Cruickshank, JK, MacDonald, Thomas M, Ford, I, Morant, S, Sever, Peter, Webb, David J, Caulfield, Mark, Brown, MJ, McInnes, G, Salsbury, J, Cruickshank, J Kennedy, Williams, Bryan, MacDonald, Thomas M., McInnes, Gordon, Salsbury, Jackie, Morant, Steve, Ford, Ian, Webb, DJ, Brown, Morris J., Cruickshank, J. Kennedy, Webb, David J., Brown, Morris, Sever, P   +25 more
core   +2 more sources

Association of spironolactone treatment and arterial stiffness and cardiovascular disease in hypertensive patients

Archives of Medical Science, 2019
Introduction The aim of the current study was to evaluate the association of spironolactone and arterial stiffness and composite cardiovascular disease (CVD, including coronary heart disease, congestive heart failure and ischemic stroke) in hypertensive ...
Fanfang Zeng, Rong Huang, Yongkang Lu, Zhiye Wu, Weiyi Mai, Lili Wang   +5 more
doaj   +1 more source

Effects of Low-Dose Spironolactone Combined with Metformin or Either Drug Alone on Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Pilot Study

International Journal of Endocrinology, 2022
Metformin and spironolactone alone can be used for the management of polycystic ovarian syndrome (PCOS), and their combination could result in even better outcomes.
Tao Long, Ying Zhang, Chunping Zeng, Siyuan Zheng, Lin Zhou, Haiyan Liu   +5 more
doaj   +1 more source

Medical treatment of ascites in cirrhosis [PDF]

, 1993
Medical treatment of cirrhotic ascites is essentially supportive, dictated by the patient's discomfort, impaired cardiovascular or respiratory function and potential for infection. Treatment of ‘simple’ ascites (moderate fluid accumulation, serum albumin
Gerbes, Alexander L.
core   +1 more source

Experience collecting interim data on mortality: an example from the RALES study. [PDF]

, 2001
INTRODUCTION: The Randomized Aldactone Evaluation Study (RALES) randomized 822 patients to receive 25 mg spironolactone daily and 841 to receive placebo. The primary endpoint was death from all causes.
Palensky, Jolie, Boissel Jean-Pierre, Desmond Julian, Pocock, Stuart, Pocock Stuart, Curt D Furberg, Janet Wittes, Barbara Roniker, Stuart Pocock, Julian Desmond, Palensky Jolie, Furberg Curt D, Roniker Barbara, Jean-Pierre Boissel, Jolie Palensky, Furberg, Curt D, Asner Debra, Debra Asner, Wittes, Janet, Wittes Janet, Julian, Desmond, Asner, Debra, Kulbertus Henri, Kulbertus, Henri, Henri Kulbertus, Roniker, Barbara, Boissel, Jean-Pierre   +26 more
core   +1 more source

Exploration of sodium homeostasis and pharmacokinetics in bile duct-ligated rats treated by anti-cirrhosis herbal formula plus spironolactone

Frontiers in Pharmacology, 2023
Renal sodium retention is an essential indicator that is used for the prognosis of cirrhosis with ascites that requires diuretic treatment to restore sodium homeostasis.
Tun-Pin Hsueh, Tun-Pin Hsueh, Tun-Pin Hsueh, Tung-Hu Tsai, Tung-Hu Tsai, Tung-Hu Tsai   +5 more
doaj   +1 more source