Biochemical characteristics associated with spironolactone use in hospitalized patients with hypotonic hyponatraemia [PDF]
Annals of MedicineBackground Spironolactone has been associated with hypotonic hyponatraemia. However, its accompanying biochemical pattern – especially with concomitant loop diuretics – remains underdescribed.
Josef Klhůfek +5 more
doaj +2 more sources
Effects of Spironolactone and Losartan on Diabetic Nephropathy in a Type 2 Diabetic Rat Model [PDF]
Diabetes & Metabolism Journal, 2011 BackgroundWhile there is an evidence that the anti-inflammatory properties of spironolactone can attenuate proteinuria in type 2 diabetes, its effects on vascular endothelial growth factor (VEGF) expression in diabetic nephropathy have not been clearly ...
Mi Young Lee +10 more
doaj +2 more sources
Predictors of treatment response to subthreshold micropulse laser and oral spironolactone therapy for central serous chorioretinopathy [PDF]
BMC OphthalmologyObjectives To identify the specific predictors of treatment response to subthreshold micropulse laser (SML) and oral spironolactone therapy in patients with central serous chorioretinopathy (CSC).
Sheng Gao +3 more
doaj +2 more sources
Journal of Pain and Symptom Management, 2017 Therapeutic Reviews aim to provide essential independent information for health professionals about drugs used in palliative and hospice care. Additional content is available on www.palliativedrugs.com. Country-specific books (Hospice and Palliative Care Formulary USA, and Palliative Care Formulary, British and Canadian editions) are also available and
Laura Carone +5 more
+7 more sources
Pharmacotherapy of patients with atrial fibrillation and restored sinus rhythm – is the medication with spironolactone beneficial in this case? [PDF]
Pharmacia, 2021 Objective: Atrial fibrillation is progressive disease with important health consequences, in which fibrosis is a key player. The aim of our study is to assess the effect of mineralcorticoid blockade on top of standard treatment in patients with atrial ...
Antoniya Kisheva +2 more
doaj +3 more sources
Protective Effect of Spironolactone on Endothelial-to-Mesenchymal Transition in HUVECs via Notch Pathway [PDF]
Cellular Physiology and Biochemistry, 2015 Background: Fibrosis results in excessive buildup of extracellular matrix proteins along with abnormalities in structure and is partly derived by a process involving transforming growth factor β (TGF-β) called endothelial-to-mesenchymal transition (EndMT)
Xiao Chen +8 more
doaj +2 more sources
Determination and Occurrence of Mineralocorticoids in Taihu Lake of China
Frontiers in Environmental Science, 2021 We developed a sensitive method for monitoring six natural (aldosterone) and synthetic mineralocorticoids (canrenone, spironolactone, 7β-spironolactone, 7α-thio spironolactone, and 7α-thiomethyl spironolactone) in sediment and water using ultra ...
Li Zhao +3 more
doaj +1 more source
Mineralocorticoid Receptor Antagonists Mitigate Mitral Regurgitation-Induced Myocardial Dysfunction
Cells, 2022 Mitral regurgitation (MR), the disruption of the mitral valve, contributes to heart failure (HF). Under conditions of volume overload, excess mineralocorticoids promote cardiac fibrosis.
Wei-Ting Chang +7 more
doaj +1 more source
Iranian Journal of Psychiatry, 2021 Objective: Spironolactone (C24H32O4S), a potent mineralocorticoid receptor (MR) inhibitor, is a potassium-sparing diuretic that is traditionally used to treat fluid build-up in the body or for its anti-androgenic properties. This study is a double-blind,
Atefeh Zandifar +3 more
doaj +1 more source
The Effect of Spironolactone on β-amyloid-Induced Memory Impairment in Male Rats: The Role of Microglial Inhibition [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose: Neuroinflammation was indicated in the pathophysiology of Alzheimer’s disease(AD). Previous reports have also signified that spironolactone has anti-inflammatory effects.Therefore, the aim of this study was to assess the modulatory effects of ...
Mohammad Mehdipour +4 more
doaj +1 more source