Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling [PDF]
Frontiers in Physiology, 2015 Type 2 diabetes (DM2) increases the risk of cardiovascular disease. Aldosterone, which has pro-oxidative and pro-inflammatory effects in the cardiovascular system, is positively regulated in DM2.
Marcondes Alves Barbosa Da Silva +7 more
doaj +5 more sources
Spironolactone for Heart Failure with Preserved Ejection Fraction [PDF]
New England Journal of Medicine, 2014 BACKGROUND: Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left ventricular ejection fraction.
Bertram Pitt +2 more
exaly +3 more sources
Possible drug reaction with eosinophilia and systemic symptoms after spironolactone therapy for clinical hyperandrogenism: a case report [PDF]
F&S ReportsObjective: To present a case of possible drug reaction with eosinophilia and systemic symptoms (DRESS) after spironolactone and to review existing literature on serious cutaneous adverse reactions to spironolactone.
Sandy Hoang, M.D. +2 more
doaj +2 more sources
Pharmacotherapy of patients with atrial fibrillation and restored sinus rhythm – is the medication with spironolactone beneficial in this case? [PDF]
Pharmacia, 2021 Objective: Atrial fibrillation is progressive disease with important health consequences, in which fibrosis is a key player. The aim of our study is to assess the effect of mineralcorticoid blockade on top of standard treatment in patients with atrial ...
Antoniya Kisheva +2 more
doaj +3 more sources
Journal of Pain and Symptom Management, 2017 Therapeutic Reviews aim to provide essential independent information for health professionals about drugs used in palliative and hospice care. Additional content is available on www.palliativedrugs.com. Country-specific books (Hospice and Palliative Care Formulary USA, and Palliative Care Formulary, British and Canadian editions) are also available and
Laura Carone +5 more
+5 more sources
Effects of Spironolactone on Proteinuria of Patients with Type 2 Diabetes [PDF]
مجله دانشکده پزشکی اصفهان, 2012 Background: Diabetic nephropathy is the most common cause of kidney failure. We investigated the beneficial effects of spironolactone, alone and in combination with hydrochlorothiazide, on diabetic nephropathy.
Mohamad Karami Horestani +3 more
doaj +2 more sources
Determination and Occurrence of Mineralocorticoids in Taihu Lake of China
Frontiers in Environmental Science, 2021 We developed a sensitive method for monitoring six natural (aldosterone) and synthetic mineralocorticoids (canrenone, spironolactone, 7β-spironolactone, 7α-thio spironolactone, and 7α-thiomethyl spironolactone) in sediment and water using ultra ...
Li Zhao +3 more
doaj +1 more source
Mineralocorticoid Receptor Antagonists Mitigate Mitral Regurgitation-Induced Myocardial Dysfunction
Cells, 2022 Mitral regurgitation (MR), the disruption of the mitral valve, contributes to heart failure (HF). Under conditions of volume overload, excess mineralocorticoids promote cardiac fibrosis.
Wei-Ting Chang +7 more
doaj +1 more source
The Effect of Spironolactone on β-amyloid-Induced Memory Impairment in Male Rats: The Role of Microglial Inhibition [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose: Neuroinflammation was indicated in the pathophysiology of Alzheimer’s disease(AD). Previous reports have also signified that spironolactone has anti-inflammatory effects.Therefore, the aim of this study was to assess the modulatory effects of ...
Mohammad Mehdipour +4 more
doaj +1 more source
Iranian Journal of Psychiatry, 2021 Objective: Spironolactone (C24H32O4S), a potent mineralocorticoid receptor (MR) inhibitor, is a potassium-sparing diuretic that is traditionally used to treat fluid build-up in the body or for its anti-androgenic properties. This study is a double-blind,
Atefeh Zandifar +3 more
doaj +1 more source