Results 101 to 110 of about 612,842 (306)

The forensic spleen: Morphological, radiological, and toxicological investigations

, 2019
The spleen is only uncommonly investigated in the forensic setting. Thorough examinations are performed in some specific situations such as splenic trauma (including iatrogenic trauma from cardiopulmonary resuscitation attempts), anaphylaxis, drowning ...
Tettamanti, Camilla, Tettamanti, C., Palmiere, Cristian, Palmiere, C., Tse, R., Scarpelli, Maria Pia, Tse, Rexson, Scarpelli, M.P.   +7 more
core   +1 more source

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

The impact of tumor burden score on prognosis in patients after radical resection of hepatocellular carcinoma: a single-center retrospective study

Frontiers in Oncology
PurposeThis study examines the relationship between tumor burden score (TBS) and survival and recurrence following radical resection of hepatocellular carcinoma through a cohort study conducted in the Guangxi population of China.MethodsThis cohort study ...
Junzhang Huang, Ying Zhou, Suosu Wei, Yuntian Tang, Qiuhuan Zhang, Yi Tang, Wei Huang, Chongde Mo, Xiaofeng Dong, Jianrong Yang   +9 more
doaj   +1 more source

An unusual case of acute pancreatitis and gastric outlet obstruction associated with wandering spleen treated by laparoscopic splenopexy.

, 2011
Wandering spleen (WS) is an uncommon condition, usually asymptomatic, often recognized as an incidental finding. When symptoms occur, they can vary, although acute abdominal pain is the most common presentation in the pediatric population. In some cases,
Retrosi, Giuseppe, L. NANNI, GAMBA, PIERGIORGIO, Magno, Stefano, G. RETROSI A. CINA, Cina, Alessandro, Stefano Magno, Nanni, Lorenzo, Pier Giorgio Gamba, S. MAGNO, Alessandro Cina, Giuseppe Retrosi, Lorenzo Nanni   +12 more
core   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Integrative machine learning and multi-omics analysis reveals ATIC as a promoter of hepatocellular carcinoma progression

Scientific Reports
Autophagy plays a non-negligible role in the progression and immune regulation of hepatocellular carcinoma (HCC). An integrated analysis of the autophagy-related genes (ARGs) is of significance to deepen our mechanistic understanding about HCC pathology.
Longhui Xie, Tiantian Wang, Changbin Pan, Jianwei Lan, Yang Yang, Lijuan Lv, Cila Zhou, Shuang Qin, Yinkuan Ning   +8 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Hydrophilic Polymers Enable Gastrointestinal Transit Monitoring by Fluorine‐19 Magnetic Resonance Imaging

Advanced Healthcare Materials, EarlyView.
Hydrophilic fluorinated copolymers dissolve in chyme and give a strong, single 19F signal, unlike phase‐separating perfluorocarbons. Combined 1H‐19F MRI tracks their whole‐gut transit non‐invasively and without ionizing radiation. In rats, the tracers move through the gastrointestinal tract, resist resorption, and are well tolerated, a proof‐of‐concept
Ondřej Groborz, Vít Herynek, Mária Hovořáková, Zuzana Pavlíková, Linda Dalecká, Klára Steklíková, Petr Matouš, Petr Páral, Margarita Tkachenko, Filip Koucký, Fatma Nalan Cetin, Ludmila Maffei Svobodová, Jiří Beneš, Kristýna Kolouchová   +13 more
wiley   +1 more source

Gastrointestinal health anti-diarrheal mixture relieves spleen deficiency-induced diarrhea through regulating gut microbiota

Open Life Sciences
This study evaluated the therapeutic efficacy of the gastrointestinal health anti-diarrheal mixture (GHAM) on diarrhea induced by spleen deficiency, focusing on its modulation of gut microbiota.
Wu Zhengquan, Yao Liuyi, Guo Jun, Xu Zhong, Wang Zhengyan   +4 more
doaj   +1 more source

The effect of gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review and network meta-analysis

Frontiers in Nutrition
BackgroundThe incidence of NAFLD is increasing. Preclinical evidences indicate that modulation of the gut microbiome could be a promising target in nonalcoholic fatty liver disease.MethodA systematic review and network meta-analysis was conducted to ...
Yijia Song, Yijia Song, Yijia Song, Sutong Liu, Lihui Zhang, Lihui Zhang, Wenxia Zhao, Yuanmei Qin, Yuanmei Qin, Minghao Liu   +9 more
doaj   +1 more source