Results 131 to 140 of about 66,709 (255)

Increased intervals in enzyme replacement therapy for stable type 1 Gaucher disease: A non‐inferiority sequential trial emulation

Journal of Internal Medicine, Volume 299, Issue 5, Page 604-614, May 2026.
Abstract Objective To compare the efficacy and safety of extended interval (Q3–4W) enzyme replacement therapy (ERT) versus standard biweekly (Q2W) ERT in clinically stable type 1 Gaucher disease (GD) patients. Methods We emulated a target trial with a sequential trial design, using data from the French Gaucher Disease Registry.
Maxime Beydon, Jérôme Stirnemann, Karima Yousfi, Samira Zebiche, Dalil Hamroun, Anaïs Brassier, Samia Pichard, Laure Swiader, Thierry Billette de Villemeur, Bénédicte Héron, Florence Dalbies, Bérengère Cador, Anne‐Sophie Guemann, Francis Gaches, Bénédicte Hivert, Vanessa Leguy‐Seguin, Agathe Masseau, Yves‐Marie Pers, Magali Pettazzoni, Soumeya Bekri, Catherine Caillaud, Edouard Le Guillou, Marie Szymanowski, Leonardo Astudillo, Wladimir Mauhin, Yann Nadjar, Christine Serratrice, Marc G. Berger, Fabrice Camou, Nadia Belmatoug, Yann Nguyen, the French Evaluation of Gaucher Disease Treatment Committee   +31 more
wiley   +1 more source

Pancreatic ductal adenocarcinoma [PDF]

, 2013
A 61-year-old gentleman who lives with his wife and 20-year-old son, presented to the polyclinic with a four week history of pruritus. On examination he was found to be jaundiced and his LFTs were high.
Bezzina, Sarah, Debattista, Daniel
core  

Radiomics‐Based Assessment of Portal Hypertension Severity and Risk Stratification of Cirrhotic Patients Using Routine CT Scans

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background & Aims To develop and validate a CT‐based radiomics model to assess HVPG and predict a composite endpoint of liver‐related events (LRE: decompensation and liver‐related death) in patients with cirrhosis. Methods This retrospective study included 357 cirrhosis patients, who received invasive HVPG measurements, 120 liver‐healthy ...
Celine Sin, Martin Luther Watzenboeck, Eugenia Iofinova, Lorenz Balcar, Georg Semmler, Bernhard Scheiner, Katharina Lampichler, Mattias Mandorfer, Lucile Moga, Pierre‐Emmanuel Rautou, Maxime Ronot, Jörg Menche, Thomas Reiberger, Martina Scharitzer   +13 more
wiley   +1 more source

Efficacy and Safety of Multivisceral Resection for Ovarian Cancer: A Comparative Study of Gynecologic Oncologists and Multidisciplinary Surgeons

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Background Advanced ovarian cancer often presents with extensive pelvic and abdominal metastases, even malignant pleural effusion. Consequently, multivisceral resection has become the common surgical approach to achieve optimal resection of ovarian cancer.
Luxin Ye, Qi Xue, Xianzhong Cheng, Ping Liu, Qian Zhao, Jiahui Chen, Xuening Wang, Yourong Chen, Xia Xu, Wenwen Guo, Jing Ni, Xiaoxiang Chen   +11 more
wiley   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

A case of hemobilia caused by a pseudoaneurysm resulting in obstructive cholangitis in a patient who underwent plastic stent placement for pancreatic cancer (with video)

DEN Open, Volume 6, Issue 1, April 2026.
Abstract Hemobilia, or hemorrhage within the biliary system, is an uncommon cause of stent obstruction associated with bile duct strictures that are rarely observed with plastic stents. Reports of a pseudoaneurysm as a cause of hemobilia after plastic stent placement are also rare.
Yusuke Seyama, Akinori Sugaya, Ken Koyama, Hiroyuki Honda, Hajime Ishibashi, Masaharu Yamaoka, Mitsuharu Ozeki, Mitsuhide Goto, Masahiro Araki, Kenji Amagai   +9 more
wiley   +1 more source

Management Strategies for Refractory Esophageal Varices

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Refractory esophageal varices that are difficult to control or unresponsive to endoscopic treatment remain a major clinical challenge in the management of portal hypertension. This review provides a comprehensive overview of treatment strategies for these cases, along with a comparative analysis of the American Association for the Study of ...
Keita Maki, Hiroaki Haga, Yoshiyuki Ueno
wiley   +1 more source

Global Burden of Sickle Cell Disease: Adequacy of Pain Control as Evidenced by Frequency of Oral Pain Medication Use, Health Outcomes, and Emotional Well‐Being Across Diverse Populations

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Introduction Sickle cell disease (SCD) is a chronic genetic disorder causing severe pain, anemia, and systemic complications that negatively affect patients’ physical and mental well‐being. The aim of this global cross‐sectional study was to evaluate the relationship between oral pain medication (OPM) use frequency and health outcomes ...
Akshat Jain, Lisa Roberts, Safiye Sahin
wiley   +1 more source

Chronic Thromboembolic Pulmonary Disease Phenotypes Using Upright Invasive Cardiopulmonary Exercise Testing

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT Patients with chronic thromboembolic pulmonary disease (CTEPD) without resting pulmonary hypertension (PH) frequently experience dyspnea which is not explained by stationary assessment and therefore requires cardiopulmonary exercise testing for further diagnostic insight.
Pradhab Kirupaharan, Jehad Azar, Xiaofeng Wang, Yifan Wang, Alice Goyanes, Tereza Izakovich, Michael Z. Tong, Haytham Elgharably, Ihab Haddadin, Adriano R. Tonelli, Gustavo A. Heresi   +10 more
wiley   +1 more source

Laparoscopic splenectomy in a case of blunt abdominal trauma

Journal of Minimal Access Surgery, 2009
Splenic rupture is a frequent consequence of blunt abdominal trauma. Removal of the spleen (splenectomy) or alternative conservative procedures (splenorrhaphy, partial splenectomy and haemostatic collagen application) are surgical treatment options ...
Agarwal Narendra
doaj