Results 141 to 150 of about 25,644 (242)
Advanced Science, Volume 13, Issue 9, 13 February 2026.Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang +9 more
wiley +1 more source
Advanced Science, Volume 13, Issue 7, 3 February 2026.Cerebral ischemia‐reperfusion injury (CIRI) is a key pathological process limiting the efficacy of stroke therapy. This study has developed an innovative, multifunctional, brain‐targeted nanoplatform (RFP) containing MXene nanoenzymes and ferroptosis inhibitors.
Lu Wang +9 more
wiley +1 more source
CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target
Advanced Science, Volume 13, Issue 8, 9 February 2026.This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang +2 more
wiley +1 more source
Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.Ultrasound contrast agents, including microbubbles and nanobubbles, transform imaging and targeted therapy through precise engineering of size, shell composition, and surface properties. This review explores how these innovations enable tissue‐specific delivery, enhance therapeutic efficacy, and extend applications from vascular imaging to tumor ...
Ashkan Seza +2 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.Pachymic acid protects blood–brain barrier (BBB) integrity by decreasing the degradation of tight junction proteins caused by tissue plasminogen activator (tPA). Pachymic acid activates the PI3K/Akt pathway via direct binding to PI3K protein, mitigating BBB damage and hemorrhagic transformation induced by tPA after ischemic stroke.
Yongshi Wu +7 more
wiley +1 more source
Beyond bacterial defences: the role of lysozyme in cancer
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.Lysozyme (LYZ) is a multi‐functional secreted factor that encompasses both antibacterial and immunomodulatory functions. Emerging evidence highlights its complex role in tumour progression by directly influencing tumour cells and modulating the immune microenvironment.
Lei Wang +4 more
wiley +1 more source
Drug Development Research, Volume 87, Issue 1, February 2026.ABSTRACT Sudden death resulting from abdominal aortic aneurysm (AAA) rupture is a highly fatal cardiovascular condition. There remains an urgent need to identify innovative therapeutic strategies capable of decelerating AAA progression and rupture. Although polydatin (PLD) has been consistently shown to exert potent anti‐inflammatory effects in diverse
Zikang Liu +4 more
wiley +1 more source
Splenic Infarction with Myocardial Injury in a Diabetic Patient: A Case Report. [PDF]
Diabetes Metab Syndr Obes, 2023 Wang C, Wen S, Zhou L.
europepmc +1 more source
Therapeutic Potential of Saikosaponins in MASLD and Cross‐Organ Protection: A Research Update
Food Science &Nutrition, Volume 14, Issue 2, February 2026.This review systematically outlines the multi‐target mechanisms of Saikosaponins (SSs) against MASLD, encompassing the regulation of lipid metabolism, insulin resistance, and inflammatory response. Furthermore, it highlights their novel cross‐organ protective effects on the cardiovascular, renal, and central nervous systems, providing therapeutic ...
Jiayao Xiong +5 more
wiley +1 more source