Results 21 to 30 of about 129,482 (378)

Elevated plasma EDA fibronectin in primary myelofibrosis is determined by high allele burden of JAK2V617F mutation and strongly predicts splenomegaly progression

open access: yesFrontiers in Oncology, 2022
In primary myelofibrosis, extra-domain A fibronectin (EDA-FN), the result of alternative splicing of FN gene, sustains megakaryocyte proliferation and confers a pro-inflammatory phenotype to bone marrow cell niches. In this work we assessed the levels of
Alessandro Malara   +6 more
doaj   +1 more source

Incidentally Detected Celiac Disease with Splenomegaly on 18F FDG PET/CT: A Potential Lymphoma Mimic [PDF]

open access: yesAsia Oceania Journal of Nuclear Medicine and Biology, 2021
Celiac disease is an immune-mediated disorder triggered by hypersensitivity to gluten occurring in genetically susceptible individuals. A high-index of suspicion is needed for diagnosis as patients can be asymptomatic or present with atypical symptoms or
Ananya Panda   +5 more
doaj   +1 more source

COVID-19: Chest Computed Tomography Imaging Patterns in Assessment of Disease Progression and Severity [PDF]

open access: yesInternational Journal of Anatomy Radiology and Surgery, 2021
Introduction: Chest Computed Tomography (CT) plays an important role in the diagnosis and management of Corona Virus Disease (COVID-19) infection.
Sachin Thammegowda   +4 more
doaj   +1 more source

Clinical overview on RASopathies

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 414-424, December 2022., 2022
Abstract RASopathies comprise a group of clinically overlapping developmental disorders caused by genetic variations affecting components or modulators of the RAS‐MAPK signaling cascade, which lead to dysregulation of signal flow through this pathway.
Martin Zenker
wiley   +1 more source

Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus

open access: yesFrontiers in Immunology, 2020
Systemic lupus erythematosus (SLE) is characterized by high levels of autoantibodies and multiorgan tissue damage. The pathogenesis of splenomegaly in SLE remains unknown. In this study, the role of immunoglobulin G (IgG) generation and deposition in the
Qian Zhang   +5 more
semanticscholar   +1 more source

Concomitant splenic artery ligation has no preventive effect on left‐sided portal hypertension following pancreaticoduodenectomy with the resection of the portal and superior mesenteric vein confluence for pancreatic ductal adenocarcinoma

open access: yesAnnals of Gastroenterological Surgery, 2022
Background Left‐sided portal hypertension (LSPH) caused by splenic vein (SV) division in pancreaticoduodenectomy (PD) with portal vein (PV) resection remains challenging. The current study aimed to investigate the efficacy of splenic artery (SA) ligation
Kazuyuki Gyoten   +9 more
doaj   +1 more source

Prediction of esophagogastric varices associated with oxaliplatin administration

open access: yesJGH Open, 2021
Background Oxaliplatin is a key drug for the chemotherapy of colorectal cancer; however, it is also known to cause non‐cirrhotic portal hypertension. We aimed to identify the characteristics of patients who developed esophagogastric varices (EGVs) after ...
Yosuke Satta   +18 more
doaj   +1 more source

PRIMARY BILIARY CHOLANGITIS DIAGNOSIS IN A SERONEGATIVE 19-YEAR-OLD WOMAN [PDF]

open access: yesEuromediterranean Biomedical Journal, 2023
Primary biliary cholangitis (PBC) is an autoimmune disease that destroys small bile ducts, culminating in liver failure. It typically affects middle-aged, Caucasian women. Most cases have detectable antimitochondrial antibodies.
Sara Santos
doaj   +1 more source

Co-Inheritance of Haemoglobin D-Punjab and Beta Thalassemia - A Rare Variant [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2017
Haemoglobinopathies are a frequent cause of anaemia in Northwestern India due to traditional practices of consanguineous marriages. Haemoglobin D-Punjab is one of the most common subvariants (55%) of haemoglobin D, which can be inherited as a homozygous
Kalyan Mansukhbhai Shekhda   +4 more
doaj   +1 more source

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