Results 21 to 30 of about 132,601 (358)
Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus
Frontiers in Immunology, 2020 Systemic lupus erythematosus (SLE) is characterized by high levels of autoantibodies and multiorgan tissue damage. The pathogenesis of splenomegaly in SLE remains unknown. In this study, the role of immunoglobulin G (IgG) generation and deposition in the
Qian Zhang +5 more
semanticscholar +1 more source
Rapamycin-filgrastim combination therapy ameliorates portal hypertension-induced splenomegaly: Role of β actin and S100A9 proteins modulation [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Thioacetamide (TAA) was administered to induce an animal model of liver disease with secondary splenomegaly to assess the mechanisms underlying the effects of rapamycin and filgrastim when taken separately or in combination on the ...
Shaimaa Abdelrahman +2 more
doaj +1 more source
Clinical Case Reports, 2022 Here we present the case of an hepato‐splenic‐Tγδ‐cell lymphoma interestingly occurring in a non‐immunocompromised patient, with profuse telangiectasias giving originally misleading orientation towards the diagnosis of B angiotropic lymphoma.
Ava Diarra +6 more
doaj +1 more source
European Journal of Case Reports in Internal Medicine, 2021 Reactive thrombocytosis after splenectomy is a feared cause of thrombosis throughout the arterial and venous system. There are many causes of splenomegaly, ranging from cirrhosis to lymphoma to hereditary spherocytosis.
Chidinma Ejikeme +5 more
doaj +1 more source
Oxaliplatin-induced haematological toxicity and splenomegaly in mice
PLoS ONE, 2020 Purpose Haematological toxicities occur in patients receiving oxaliplatin. Mild anaemia (grade 1–2) is a common side effect and approximately 90% of recipients develop measurable spleen enlargement.
J. Lees +6 more
semanticscholar +1 more source
Splenomegaly Segmentation on Multi-Modal MRI Using Deep Convolutional Networks [PDF]
IEEE Transactions on Medical Imaging, 2018 The findings of splenomegaly, abnormal enlargement of the spleen, is a non-invasive clinical biomarker for liver and spleen diseases. Automated segmentation methods are essential to efficiently quantify splenomegaly from clinically acquired abdominal ...
Yuankai Huo +10 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 Background: Granulomatous and Lymphocytic Interstitial Lung Diseases (GLILD) is a severe non-infectious complication of Common Variable Immunodeficiency (CVID), often associated with extrapulmonary involvement.
Francesco Cinetto +35 more
doaj +1 more source
IRF-5 Expression in Myeloid Cells Is Required for Splenomegaly in L. donovani Infected Mice
Frontiers in Immunology, 2020 Persistent Leishmania donovani infection is characterized by chronic inflammation, immune suppression, and splenomegaly. We have previously reported that the transcription factor interferon regulatory factor 5 (IRF-5) is largely responsible for inducing ...
Linh Thuy Mai +4 more
doaj +1 more source
Prediction of esophagogastric varices associated with oxaliplatin administration
JGH Open, 2021 Background Oxaliplatin is a key drug for the chemotherapy of colorectal cancer; however, it is also known to cause non‐cirrhotic portal hypertension. We aimed to identify the characteristics of patients who developed esophagogastric varices (EGVs) after ...
Yosuke Satta +18 more
doaj +1 more source
Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice [PDF]
, 2016 Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals, there are two converging apoptosis pathways: the ‘extrinsic’ pathway, which is triggered by engagement of cell surface ‘death ...
Anstee, Natasha S. +5 more
core +15 more sources