Results 31 to 40 of about 132,601 (358)

Gaucher Disease and Myelofibrosis: A Combined Disease or a Misdiagnosis? [PDF]

, 2018
Background: Gaucher disease (GD) and primary myelofibrosis (PMF) share similar clinical and laboratory features, such as cytopenia, hepatosplenomegaly, and marrow fibrosis, often resulting in a misdiagnosis.
Cardarelli, L, Foà, R, Giona, F, Mariani, S, Palumbo, G, Santopietro, M   +5 more
core   +1 more source

Clinical presentation of splenomegaly at Kigali University Teaching Hospital, Rwanda - A retrospective descriptive study [PDF]

Rwanda Medical Journal, 2020
INTRODUCTION: Splenomegaly is a common condition in malaria endemic region and is frequently associated with cytopenias. Splenomegaly is usually a clinical finding, but imaging studies have helped to assess for or confirm it.
E. Nkusi, E. Nziyomaze, R. Salama, V. Musengamana, C. Mukamukama, M.G. Nyirabizimana, F. Hakizimana, F. Shikama   +7 more
doaj  

Elevated plasma EDA fibronectin in primary myelofibrosis is determined by high allele burden of JAK2V617F mutation and strongly predicts splenomegaly progression

Frontiers in Oncology, 2022
In primary myelofibrosis, extra-domain A fibronectin (EDA-FN), the result of alternative splicing of FN gene, sustains megakaryocyte proliferation and confers a pro-inflammatory phenotype to bone marrow cell niches. In this work we assessed the levels of
Alessandro Malara, Cristian Gruppi, Margherita Massa, Maria Enrica Tira, Vittorio Rosti, Alessandra Balduini, Giovanni Barosi   +6 more
doaj   +1 more source

Epidemiology of Malaria in an Area Prepared for Clinical Trials in Korogwe, North-eastern Tanzania. [PDF]

, 2009
Site preparation is a pre-requesite in conducting malaria vaccines trials. This study was conducted in 12 villages to determine malariometric indices and associated risk factors, during long and short rainy seasons, in an area with varying malaria ...
Acleus S Rutta, AE Mnzava, AM Ronn, Bruno P Mmbando, CA Maxwell, CJ Drakeley, CJ Drakeley, Deus S Ishengoma, DG Heppner Jr, E Kahigwa, Filbert Francis, H Dirren, Hamisi A Msangeni, J Keiser, JC Beier, JG Siri, JP Lusingu, JP Lusingu, JP Shott, KN Suh, M Alifrangis, Martha M Lemnge, Mathias L Kamugisha, Method D Segeja, Misago D Seth, PB Bloland, R Bodker, R Bodker, RW Snow, S Vyas, Samwel H Sembuche, V Robert, WL Kilama, WL Kilama   +33 more
core   +3 more sources

Challenges in the diagnosis of gaucher disease with multiple splenic lesions

Journal of Applied Hematology, 2023
The progressive nature, multisystem involvement, and delayed diagnosis of Gaucher disease (GD) make it a challenging disorder. Herein, we report the clinical and genetic findings of a patient with GD of Saudi-Arab ethnicity. In this case, a young patient
Ahmad Alshomar
doaj   +1 more source

Splenomegaly segmentation using global convolutional kernels and conditional generative adversarial networks [PDF]

Medical Imaging, 2017
Spleen volume estimation using automated image segmentation technique may be used to detect splenomegaly (abnormally enlarged spleen) on Magnetic Resonance Imaging (MRI) scans.
Yuankai Huo, Zhoubing Xu, Shunxing Bao, Camilo Bermudez, A. Plassard, Jiaqi Liu, Yuang Yao, A. Assad, R. Abramson, B. Landman   +9 more
semanticscholar   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Presenting signs and patient co-variables in Gaucher disease : outcome of the Gaucher Earlier Diagnosis Consensus (GED-C) Delphi initiative [PDF]

, 2019
© 2018 The Authors. Internal Medicine Journal by Wiley Publishing Asia Pty Ltd on behalf of Royal Australasian College of Physicians.Background: Gaucher disease (GD) presents with a range of signs and symptoms.
Belmatoug , N, Bembi , B, Bright, J, Deodato, F, Di Rocco, M, Goker-Alpan, O, Hughes, DA, Kuter, David, Lukina, EA, Machaczka, M, Mehta, Atul, Mengel, E, Nagral, A, Nakamura, K, Narita, A, Oliveri , B, Pastores, G, Pérez-López, J, Ramaswami, U, Salek, Mir-Saeed Shayegan, Schwartz, IV, Szer, J, Vom Dahl, S, Weinreb, NJ, Zimran, A   +24 more
core   +6 more sources

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Epidemiology of malaria in the Taabo health and demographic surveillance system, south-central Côte d'Ivoire [PDF]

, 2016
A deep understanding of the local epidemiology of malaria is essential for the design and implementation of setting-specific control and elimination efforts.
Adiossan, Lukas G., Baikoro, Nahoua, Bassa, Fidèle K., Bonfoh, Bassirou, Koné, Siaka, N'Cho, Moussan, N'Goran, Eliézer K., Ouattara, Mamadou, Silué, Kigbafori D., Traoré, Mahamadou, Utzinger, Jürg   +10 more
core   +2 more sources