Results 221 to 230 of about 143,230 (264)
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Improved Splice Site Detection in Genie
Journal of Computational Biology, 1997We present an improved splice site predictor for the genefinding program Genie. Genie is based on a generalized Hidden Markov Model (GHMM) that describes the grammar of a legal parse of a multi-exon gene in a DNA sequence. In Genie, probabilities are estimated for gene features by using dynamic programming to combine information from multiple content ...
Martin G. Reese +3 more
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Nature, 1985
Analysis of messenger RNA splicing in yeast and in metazoa has led to the identification of an RNA molecule in a lariat conformation. This structure has been found as an mRNA splicing intermediate in vitro and identical molecules have been identified in vivo.
B C, Rymond, M, Rosbash
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Analysis of messenger RNA splicing in yeast and in metazoa has led to the identification of an RNA molecule in a lariat conformation. This structure has been found as an mRNA splicing intermediate in vitro and identical molecules have been identified in vivo.
B C, Rymond, M, Rosbash
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SPLICE SITE SELECTION IN PLANT PRE-mRNA SPLICING
Annual Review of Plant Physiology and Plant Molecular Biology, 1998▪ Abstract The purpose of this review is to highlight the unique and common features of splice site selection in plants compared with the better understood yeast and vertebrate systems. A key question in plant splicing is the role of AU sequences and how and at what stage they are involved in spliceosome assembly.
J. W. S., Brown, C. G., Simpson
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Translation across the 5′‐splice site interferes with autocatalytic splicing
Molecular Microbiology, 1993SummaryThe bacteriophage T4 nrdB gene, encoding the ribonucleotide reductase small subunit, contains a self‐splicing group IA2 intron with an ochre codon in frame with the preceding exon sequence. The stop codon was changed to an amino acid codon and splicing efficiency was compared with that of the wild type in the presence and absence of translation.
M, Ohman-Hedén +3 more
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Substrate recognition and splice site determination in yeast tRNA splicing
Cell, 1988S. cerevisae tRNA introns interrupt the gene at a constant position in the anticodon loop. Pre-tRNAs are matured by an endonuclease and a ligase. The endonuclease alone can accurately release the intron from the pre-tRNA. Here, we investigate the mechanism of splice site selection by the endonuclease. We propose that it initially recognizes features in
V M, Reyes, J, Abelson
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Science of Aging Knowledge Environment, 2006
Slicing messenger RNA molecules in the wrong position cuts short the lives of children with a disease that resembles speedy aging, and new research suggests that cells from old people make the same mistake. The finding implies that normal aging shares a mechanism with the rare genetic ailment.
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Slicing messenger RNA molecules in the wrong position cuts short the lives of children with a disease that resembles speedy aging, and new research suggests that cells from old people make the same mistake. The finding implies that normal aging shares a mechanism with the rare genetic ailment.
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Characterization and prediction of alternative splice sites
Gene, 2006Human alternative isoform, cryptic, skipped, and constitutive splice sites from the ALTEXTRON database were analysed regarding splice site strength, composition, GC content, position and binding site strength of polypyrimidine tract and branch site. Several features were identified which distinguish alternative isoform and cryptic splice sites, but not
Magnus, Wang, Antonio, Marín
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Combinatorial method of splice sites prediction
2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05), 2006Predicting and proper ranking of splice sites (SS) is a challenging problem in bioinformatics and machine learning communities. Proposed method of donor and acceptor SSs prediction is based on counting oligonucleotide frequencies for splice and splice-like signals. Based on bayesian principle SS sensors were built.
Alexander G. Churbanov, Hesham H. Ali
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To metastasize or not? Selection of CD44 splice sites
Nature Medicine, 1995The role of the CD44 cell surface molecule in tumorigenesis has been the focus of intense debate. Now enough pieces are known to begin putting the puzzle together.
D L, Cooper, G J, Dougherty
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New Methods for Splice Site Recognition
2002Splice sites are locations in DNA which separate protein-coding regions (exons) from noncoding regions (introns). Accurate splice site detectors thus form important components of computational gene finders. We pose splice site recognition as a classification problem with the classifier learnt from a labeled data set consisting of only local information
Sören Sonnenburg +3 more
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