Results 171 to 180 of about 303,737 (269)

Unraveling the Molecular Mechanism of Pre-mRNA Splicing From Multi-Scale Simulations

Frontiers in Molecular Biosciences, 2019
Lorenzo Casalino, Alessandra Magistrato
doaj   +1 more source

Outstanding Questions to Understand and Target Splicing Factor-Mutant Blood Cancers. [PDF]

Blood Cancer Discov
Maron MI, Abdel-Wahab O.
europepmc   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Isoforms in action: The impact of transcript diversity in phenotype. [PDF]

Genet Mol Biol
Mamede I, Mata-Machado C, Reis C, Amaral PP, Franco GR.   +4 more
europepmc   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

IsoPepTracker: An interactive web application for peptide-driven isoform analysis. [PDF]

PLoS Comput Biol
Mahmud A, Huang C.
europepmc   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Comprehensive review and assessment of multi-species splicing variant prediction: task-specific deep learning models and genomic foundation models. [PDF]

Brief Bioinform
Sun Y, Wang X, Jia Y, Imoto S, Li F, Li C, Song J.   +6 more
europepmc   +1 more source

Polypeptide splicing [PDF]

Proceedings of the National Academy of Sciences, 1976
openaire   +2 more sources