Results 181 to 190 of about 641,965 (315)

Cell Surface Ion-Seq: Potassium Ion Monitoring in the Colorectal Cancer Cellular Microenvironment Based on Split G‑quadruplex Probe. [PDF]

ACS Cent Sci
Huang Z, Shi X, Yang Y, Ma W, Li H, Jin Z, Feng Y, Luo C, Zheng L, Du Z, Liu C, Liu C, Liu Y, Wu Q, Liu L, Peng R, Tan W.   +16 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Design and analysis of a GaN-based 2D photonic crystal biosensor integrated with machine learning techniques for detection of skin diseases. [PDF]

Sci Rep
N H, A S.
europepmc   +1 more source

Modeling the Yield of Glycine max (L.) Merrill Using Mixture Process Variable Model within an Optimal Split-Plot Design

, 2023
Samson W. Wanyonyi, Julius Koech
openalex   +2 more sources

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Split Body Trials in Systematic Reviews and Meta-Analyses: A Tutorial. [PDF]

Cochrane Evid Synth Methods
Livingstone N, Dwan K, Chaplin M.
europepmc   +1 more source

Type I Error Rates of the Kenward-Roger <em>F</em>-test for a Split-Plot Design with Missing Values and Non-Normal Data

, 2008
Miguel A. Padilla, Youngkyoung Min, Guili Zhang   +2 more
openalex   +2 more sources

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Exploring the synergy between aluminum powder and silica fume in enhancing lightweight concrete characteristics. [PDF]

Sci Rep
Khan MB, Baarimah AO, Banaimoon MSM, Ramu MB, Ebrahim AFMS, Alsulami BT, Almujibah H.   +6 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source