To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Inconsistency was more prevalent than reported: an empirical study of 57 networks with multiple treatments using the node-splitting approach and a novel interpretation index. [PDF]
Spineli LM.
europepmc +1 more source
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Performance evaluation and TiGRA-based multi-response optimization of sustainable fly ash-slag-based one-part alkali-activated concrete mix design. [PDF]
Sheelavantar PG, Pandit P, Prashant S.
europepmc +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Intrinsic and extrinsic feedback generate similar propulsion but distinct biomechanical strategies during split-belt walking. [PDF]
Bin Shuwayyi HK +6 more
europepmc +1 more source
Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source
Differences in drug intake levels (high versus low takers) do not necessarily imply distinct drug user types: Insights from a new cluster-based model. [PDF]
Castaneda DM, Job MO.
europepmc +1 more source
Application of Split-plot Design to the Nutritional Evaluation of Rapeseed Meal
Minoru Yoshida
openalex +1 more source

