Results 1 to 10 of about 221,778 (302)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Reducing the number of experiments in split-plot optimization designs
Journal of the Brazilian Chemical Society, 2004 Two experiment reduction procedures for split-plot designs are investigated using a data set containing 160 experiments, consisting of 80 duplicate results for the optimization of a water-acetone-N,N-dimethylformamide mixture with HCl, o-dianisidine and ...
Bortoloti João A. +2 more
doaj
Ziraa'ah: Majalah Ilmiah Pertanian, 2016 The reaserch was conducted to analizies the interaction of the responsibilities of varieties, N and chicken manure fertillizer, analizies of varieties treatment, analizies dosage of N and chicken manure fertilizer to growth, yield an quality of kenaf ...
Hadi Pranoto
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Gradual correction of phosphorus availability in the no-tillage system
Revista Ceres, 2016 In areas cultivated under no-tillage system, the availability of phosphorus (P) can be raised by means of the gradual corrective fertilization, applying phosphorus into sowing furrows at doses higher than those required by the crops.
Carlos Hissao Kurihara +4 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Soil Carbon Characteristics of a Fluvisol Affected by Aggregates from Two Tillage and Crop Regimes
Journal of Applied Sciences and Environmental Management, 2013 We investigated soil carbon characteristics of a Fluvisol as influenced by different ped sizes and crop types for a period of 10 years in Owerri, Southeastern Nigeria. The experimental design was a split-split plot arranged in a randomized complete block
Emmanuel Onweremadu +2 more
doaj +2 more sources
GCB BioenergyWhile biochar and manure can provide considerable benefits to soil properties, how these amendments may alter soil microbial activity and decomposition processes remains unknown.
Ruirui Zhao +4 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source