Results 71 to 80 of about 149,581 (278)

Local-global principles for Galois cohomology

, 2012
This paper proves local-global principles for Galois cohomology groups over function fields $F$ of curves that are defined over a complete discretely valued field.
Harbater, David, Hartmann, Julia, Krashen, Daniel   +2 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Perfect Roman Domination: Aspects of Enumeration and Parameterization

Algorithms
Perfect Roman Dominating Functions and Unique Response Roman Dominating Functions are two ways to translate perfect code into the framework of Roman Dominating Functions.
Kevin Mann, Henning Fernau
doaj   +1 more source

A Linear Kernel for Planar Total Dominating Set

, 2018
A total dominating set of a graph $G=(V,E)$ is a subset $D \subseteq V$ such that every vertex in $V$ is adjacent to some vertex in $D$. Finding a total dominating set of minimum size is NP-hard on planar graphs and W[2]-complete on general graphs when ...
Garnero, Valentin, Sau, Ignasi
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

The Issues of Reislamization in Post-Soviet Dagestan in 1990–1995

Вестник Кемеровского государственного университета, 2018
The process of the Islam revival in Dagestan was associated with the politicization of religion in society during perestroika and post-perestroika periods.
O. B. Khalidova, R. I. Seferbekov
doaj   +1 more source

Holes in the walls: primordial black holes as a solution to the cosmological domain wall problem

, 2005
We propose a scenario in which the cosmological domain wall and monopole problems are solved without any fine tuning of the initial conditions or parameters in the Lagrangian of an underlying filed theory. In this scenario domain walls sweep out (unwind)
A. Vilenkin, B. J. Carr, B. J. Carr, Dejan Stojkovic, Glenn D. Starkman, Katherine Freese, M. Yu. Khlopov, S. G. Rubin   +7 more
core   +1 more source