Results 51 to 60 of about 377,779 (226)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Strong convergence of an extragradient-type algorithm for the multiple-sets split equality problem

Journal of Inequalities and Applications, 2017
This paper introduces a new extragradient-type method to solve the multiple-sets split equality problem (MSSEP). Under some suitable conditions, the strong convergence of an algorithm can be verified in the infinite-dimensional Hilbert spaces.
Ying Zhao, Luoyi Shi
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Weak Convergence Theorems on the Split Common Fixed Point Problem for Demicontractive Continuous Mappings

Journal of Function Spaces, 2018
We are concerned with the split common fixed point problem in Hilbert spaces. We propose a new method for solving this problem and establish a weak convergence theorem whenever the involved mappings are demicontractive and Lipschitz continuous.
Huanhuan Cui, Luchuan Ceng, Fenghui Wang
doaj   +1 more source

On equilibrium shapes of charged flat drops

, 2018
Equilibrium shapes of two-dimensional charged, perfectly conducting liquid drops are governed by a geometric variational problem that involves a perimeter term modeling line tension and a capacitary term modeling Coulombic repulsion.
Abramowitz, Alberti, Ambrosio, Ambrosio, Andelman, Barrero, Basaran, Bohr, Bonacini, Borell, Braides, Bucur, Burton, Caffarelli, Castro-Hernández, Choksi, Choksi, Colesanti, Dudko, Emery, Figalli, Fontelos, Frank, Frank, Gamow, Gardner, Garzon, Gaskell, Goldman, Goldman, Goldman, Julin, Knüpfer, Knüpfer, Knüpfer, Landau, Landkof, Lu, Maz'ja, Muratov, Muratov, Nezza, Novaga, Pólya, Pólya, Rayleigh, Samaddar, Schneider, Taylor, Weizsäcker, Zeleny   +50 more
core   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Multiblock ADMM Heuristics for Mixed-Binary Optimization on Classical and Quantum Computers

IEEE Transactions on Quantum Engineering, 2020
Solving combinatorial optimization problems on current noisy quantum devices is currently being advocated for (and restricted to) binary polynomial optimization with equality constraints via quantum heuristic approaches.
Claudio Gambella, Andrea Simonetto
doaj   +1 more source

Splitting Proofs for Interpolation

, 2017
We study interpolant extraction from local first-order refutations. We present a new theoretical perspective on interpolation based on clearly separating the condition on logical strength of the formula from the requirement on the com- mon signature ...
A Cimatti, A Podelski, B Dutertre, F Alberti, G Sutcliffe, J Christ, KL McMillan, KL McMillan, KL McMillan, L Kovács, L Kovács, L Moura, MP Bonacina, R Jhala, W Craig   +14 more
core   +2 more sources

Multiplicative Noise Removal Using Variable Splitting and Constrained Optimization [PDF]

, 2010
Multiplicative noise (also known as speckle noise) models are central to the study of coherent imaging systems, such as synthetic aperture radar and sonar, and ultrasound and laser imaging.
Bioucas-Dias, José M., Figueiredo, Mário A. T.   +1 more
core   +3 more sources