Results 111 to 120 of about 221,778 (302)
Constructing General Orthogonal Fractional Factorial Split-Plot Designs
, 2015 While the orthogonal design of split-plot fractional factorial experiments has received much attention already, there are still major voids in the literature.
Peter Goos (805576) +8 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Tests for the strip-split plot design
, 2016 In this article we present the structure of the F tests, the variance components and the approximate degrees of freedom for each of the eight possible mixed models of the strip-split plot design.
Díaz-Pachón, Daniel +2 more
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Comparison of the Optimal Design: Split-Plot Experiments
, 2012 Over the past decade, there have been rapid advances in the development of methods for the design and analysis of optimal split-plot experiment. Industrial experimentation involving optimality criteria has not been fully exhausted.
Francis, Ogege Ikhata, Mbegbu, Julian
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Individual control treatment in split-plot experiments
Incomplete block design, Split-plot design, Control–treatment, General balance, Efficiency factors, 62K15, 62K10,
Iwona Mejza +3 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
, 2019 These split-violin plots combine box plot indicating first and third quartiles and vertical lines 10th and 90th percentiles. Blue colour represents the data sets of the team while green is assigned to the opponents.
Bruno Gonçalves (211071) +5 more
core +1 more source