Results 111 to 120 of about 963,610 (298)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Durum wheat growth analysis in a semiarid environment in relation to crop rotation and nitrogen rate [PDF]
, 2004 SUMMARY – A research on durum wheat growth analysis was carried out at Sparacia farm (37°37’N-13°42’E) during the 2000-2001 and 2001-2002 seasons in a typical semi-arid environment.
GRISTINA, Luciano +4 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Lexis: An R Class for Epidemiological Studies with Long-Term Follow-Up [PDF]
The Lexis class in the R package Epi provides an object-based framework for managing follow-up time on multiple time scales, which is an important feature of prospective epidemiological studies with long duration.
Bendix Carstensen, Martyn Plummer
core +1 more source
Tillage and cover cropping effects on soil properties and crop production [PDF]
, 2016 Cover crops (CCs) have been heralded for their potential to retain nutrients in the field and improve soil properties, but their adoption within the Midwestern Corn-Belt remains limited.
Dozier, Ivan A
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Effect of Nitrogen Fertilizer Dose and Application Timing on Yield and Nitrogen Use Efficiency of Irrigated Hybrid Rice under Semi-Arid Conditions [PDF]
, 2019 Nitrogen fertilizer is the major input in rice production and the optimum rate and application timing management assure profitability and sustainability of the production system.
Ametonou, F.Y. +5 more
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