Results 101 to 110 of about 221,778 (302)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Repeatability of traits evaluated in a split-plot or factorial experiment
Crop Breeding and Applied Biotechnology, 2003 split-plot and factorial models, both in a randomized complete block design. The paper also considers different fixed and random effect models and their assumptions and restrictions.
Cosme Damião Cruz +1 more
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Testing for lack of fit in blocked and split-plot response surface designs
Textbooks on response surface methodology emphasize the importance of lack-of-fit tests when fitting response surface models, and stress that, to be able to test for lack of fit, designed experiments should have replication and allow for pure-error ...
Gilmour, Steven G.
core
Split-Plot Designs with Mirror Image Pairs as Subplots
, 2011 In this article we investigate two-level split-plot designs where the sub-plots consist of only two mirror image trials. Assuming third and higher order interactions negligible, we show that these designs divide the estimated effects into two orthogonal ...
Kulahci, Murat, +8 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
D-optimal design of split-split-plot experiments
In industrial experimentation there is growing interest in studies that span more than one processing step. Convenience often dictates restrictions in randomization in passing from one processing step to another.
GOOS, Peter, BRADLEY, Jones
core
Selecting optimal follow-up split-plot designs
, 2019 Split-plot designs and follow-up designs have been considered in literature for many years. However, no research has been done on selecting optimal follow-up split-plot designs for response surface methodology. In this thesis, we will find optimal follow-
Yang, Bowei
core