Results 81 to 90 of about 1,101,660 (280)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Testing for lack of fit in blocked and split-plot response surface designs
Textbooks on response surface methodology emphasize the importance of lack-of-fit tests when fitting response surface models, and stress that, to be able to test for lack of fit, designed experiments should have replication and allow for pure-error ...
Gilmour, Steven G.
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
D-optimal design of split-split-plot experiments
, 2007 : In industrial experimentation there is growing interest in studies that span more than one processing step. Convenience often dictates restrictions in randomization in passing from one processing step to another.
Goos, Peter, Jones, Bradley
core +1 more source
Minimum aberration two-level split-plot designs [PDF]
, 1995 In this thesis a certain aspect of fractionated two-level split-plot designs is associated with a subset of the 2 \u27k fractional factorial designs.
Huang, Peng
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
D-optimal design of split-split-plot experiments
, 2009 : In industrial experimentation, there is growing interest in studies that span more than one processing step. Convenience often dictates restrictions in randomization in passing from one processing step to another.
Goos, Peter, Jones, Bradley
core +2 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Onion Response to Seeding and Irrigation Depths and Wheat Straw Mulching under Drip Irrigation
HortTechnologyTo improve onion (Allium cepa L.) productivity and soil health, optimizing cultural practices such as drip tape placement, straw mulching, and onion seed depth are crucial in semiarid environments.
Udayakumar Sekaran +4 more
doaj +1 more source
Computational Statistics & Data Analysissponsorship: The authors thank Eric Schoen for providing the benchmark design for the agricultural prototype experiment in ...
Born, Mathias, Goos, Peter
openaire +5 more sources