Results 171 to 180 of about 221,778 (302)

Efficacy and Safety of Laser-Based Therapies for Melasma: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Aljoaib NN, Baltoyour A, Al-Sharif M, Salem HE, Alsharif SM, Alzahrani SJ, Alotbi TH, Maghazel RH, Alqarni OS, Alsayed SA, Alkhalagi RF, Najmi EA, Altowerki BA, Alluhaibi ST, Alrehaili LA.   +14 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Can machine learning predict non-suicidal self-injury? A systematic review and meta-analysis. [PDF]

Front Public Health
Wen Q, Luo R, Wang Q.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

EZ-Pair graph: scalable unified-axis visualization method for summarizing large-scale paired data. [PDF]

Bioinform Adv
Ezoe A, Seki M, Mochida K.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Explainable Bidirectional Long Short-Term Memory Networks Learn Chemistry from SMILES for Predicting Toxicity of Androgen and Estrogen Receptor Chemicals. [PDF]

ACS Omega
Cutropia F, Mastrolorito F, Gambacorta N, Togo MV, Amenduni V, Belgiovine V, Tondo AR, Siragusa L, Trisciuzzi D, Ciriaco F, Amoroso N, Nicolotti O.   +11 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Comparison of Bracket Adhesion Failure Rates with Resin-Modified Glass Ionomer Cement Versus Conventional Resin Adhesives: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

Dent J (Basel)
Sevindik CN, Barmak AB, Rossouw PE, Javed F.   +3 more
europepmc   +1 more source