Results 131 to 140 of about 8,275 (244)

Smoothing method for unit quaternion time series in a classification problem: an application to motion data. [PDF]

Sci Rep, 2023
Ballante E, Bellanger L, Drouin P, Figini S, Stamm A.   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Novel Walking Activity Recognition Model for Rotation Time Series Collected by a Wearable Sensor in a Free-Living Environment. [PDF]

Sensors (Basel), 2022
Brard R, Bellanger L, Chevreuil L, Doistau F, Drouin P, Stamm A.   +5 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Plug-and-play computational method for advancing natural and biomedical image representation. [PDF]

Patterns (N Y)
Gong H, Han T, Li G.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Photonic non-Abelian topological insulators with six bands. [PDF]

Nat Commun
Jiang T, Tian ZN, Tao R, Zhang RY, Zhang C, Chen QD, Wang Z, Cheng X, Chan CT, Zhang XL.   +9 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Left Regular Functions from the Quaternions to the Split-Quaternions

Fundamental Journal of Mathematics and Applications
In this paper, we study the regularity of $\mathbb{R}$-differentiable functions on open connected subsets of the scaled hypercomplex numbers $\left\{ \mathbb{H}_{t}\right\} _{t\in[-1.1]}$, in terms of the well-defined differential operators $\left\{ \nabla_{t}\right\} _{t\in\left[-1,1\right]}$, where $\left[-1,1\right]$ is the closed interval in ...
openaire   +1 more source

Identification of Defects in Low-Speed and Heavy-Load Mechanical Systems Using Multi-Fusion Analytic Mode Decomposition Method. [PDF]

Sensors (Basel)
Liu Y, Zhang K, Yang M, Zhang X, Xu Y.
europepmc   +1 more source