Results 151 to 160 of about 8,275 (244)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Accurate Lattice Free Energies of Packing Polymorphs from Probabilistic Generative Models. [PDF]

J Chem Theory Comput
Olehnovics E, Liu YM, Mehio N, Sheikh AY, Shirts MR, Salvalaglio M.   +5 more
europepmc   +1 more source

Posture Assessment in Dentistry for Different Visual Aids Using 2D Markers. [PDF]

Sensors (Basel), 2021
Pispero A, Marcon M, Ghezzi C, Massironi D, Varoni EM, Tubaro S, Lodi G.   +6 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

4D hypercomplex-valued neural network in multivariate time series forecasting. [PDF]

Sci Rep
Kycia R, Niemczynowicz A.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Fuzzy adaptive nonlinear MIMO control for rigid coupled multibody robots using reinforcement learning model. [PDF]

Sci Rep
Duan C, Wang L, Li S.
europepmc   +1 more source

Orientation control strategies and adaptation to a visuomotor perturbation in rotational hand movements. [PDF]

PLoS Comput Biol, 2022
Zruya O, Nisky I.
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

<i>LaueMatching</i>: an approach for rapid and robust indexing of Laue diffraction patterns. [PDF]

J Appl Crystallogr
Sharma H, Sheyfer D, Harder R, Tischler JZ.   +3 more
europepmc   +1 more source