Results 121 to 130 of about 659,828 (336)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Influence of Splitter Blades on the Cavitation Performance of a Double Suction Centrifugal Pump
Advances in Mechanical Engineering, 2014 In order to study the influence of splitter blades on double suction centrifugal pumps two impellers with and without splitter blades were investigated numerically and experimentally.
Wei Yang +3 more
doaj +1 more source
Flow Visualisation Studies On Wall Mounted Pitot Type Intake With Splitter Plate [PDF]
, 1991 Flow Visualisation Studies Employing Schlieren/Shadowgraph Technique And -Simple Oil Flow Technique Were Carried Out On A Simple Pitot Type Of 1-Btake With Splitter Plate Mounted On Base Plate In The NAL 0 .3m Tunnel .
Narasimhaswamy, KN, Ramaswamy, MA
core
Planar-type polarization beam splitter based on a bridged silicon waveguide coupler.
Optics Express, 2015 We demonstrate a compactly integrated polarization beam splitter (PBS) with high polarization extinction ratios greater than 20 dB over the full C-band wavelength range based on a simple bridged silicon nanowaveguide directional coupler.
Dong Wook Kim +3 more
semanticscholar +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Advances in Mechanical EngineeringSplitter-blade impellers are increasingly being adopted in centrifugal pumps due to their superior performance. However, their service life is significantly reduced when handling fluids containing even small amounts of sediment.
Haiyan Zhao +4 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Quantum Memristors in Quantum Photonics
, 2018 We propose a method to build quantum memristors in quantum photonic platforms. We firstly design an effective beam splitter, which is tunable in real-time, by means of a Mach-Zehnder-type array with two equal 50:50 beam splitters and a tunable retarder ...
Lamata, L., Sanz, M., Solano, E.
core +1 more source