Results 121 to 130 of about 22,651 (250)

Interferon beta-1b in secondary progressive MS: a combined analysis of the two trials

, 2004
BACKGROUND: A European (EU) and a North American (NA) placebo-controlled study with interferon beta-1b (IFNB-1b) in secondary progressive multiple sclerosis (SPMS) showed divergent results with regard to their primary outcome of sustained Expanded ...
BOARD, POLMAN C, WEINSHENKER B, THOMPSON AJ, BECKMANN K, MULTIPLE SCLEROSIS TRIAL STEERING COMMITTEE AND INDEPENDENT ADVISORY BOARD, DAHLKE F, NORTH AMERICAN NA SPMS INTERFERON BETA B. IN SECONDARY PROGRESSIVE, MCFARLAND H, EUROPEAN EU SPMS INTERFERON BETA B. IN SECONDARY, POZZILLI, Carlo, KAPPOS L, PROGRESSIVE MULTIPLE SCLEROSIS TRIAL STEERING COMMITTEE AND INDEPENDENT ADVISORY   +12 more
core  

High incidence of lung cancer death after curative endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma

Cancer Medicine
Background and Aim Following treatment of superficial esophageal squamous cell carcinoma (ESCC), surveillance for a second primary malignancy (SPM) is necessary. However, detailed evidence regarding the timing and prognosis of SPMs is insufficient.
Ayaka Tajiri, Yoshiki Tsujii, Tsutomu Nishida, Takuya Inoue, Akira Maekawa, Shinji Kitamura, Shinjiro Yamaguchi, Akihiro Nishihara, Takuya Yamada, Hideharu Ogiyama, Yoko Murayama, Shunsuke Yamamoto, Satoshi Egawa, Ryotaro Uema, Takeo Yoshihara, Yoshito Hayashi, Tetsuo Takehara   +16 more
doaj   +1 more source

Preoperative limbic cortical thinning in mesial temporal lobe epilepsy surgical candidates is associated with pre‐existing and de novo postoperative depression

Epileptic Disorders, EarlyView.
Abstract Objective Depression is common in mesial temporal lobe epilepsy (mTLE), but its neuroanatomical basis—and overlap with major depressive disorder (MDD)—remains poorly defined. We investigated whether the cortical and subcortical alterations reported in MDD are also present in mTLE and leveraged the frequent occurrence of depression after ...
Philip Fink‐Jensen, Brice Ozenne, Ane Kloster, Bo Jespersen, Kirsten Vinter, Guido Rubboli, Martin Balslev Jørgensen, Sandor Beniczky, Melanie Ganz, Lars Hageman Pinborg   +9 more
wiley   +1 more source

Risk prediction of second primary malignancies in patients with primary gastric neuroendocrine neoplasms: a population-based study

Discover Oncology
Purpose Patients with gastric neuroendocrine neoplasms (GNENs) face elevated risks of second primary malignancies (SPMs), yet tools for personalized risk prediction are lacking. This study aimed to explore the risk factors associated with the development
Peipei Yang, Yuanyuan Xu, Wenjie Huang, Qiurong Li, Peng Shu   +4 more
doaj   +1 more source

Pathological hippocampal–cortical hypersynchronization disrupts memory in temporal lobe epilepsy: A multimodal intracranial electroencephalographic–functional magnetic resonance imaging study

Epilepsia, EarlyView.
Abstract Objective Memory impairment is a common comorbidity in temporal lobe epilepsy (TLE) and is thought to arise from hippocampal dysfunction and disrupted interactions within a distributed memory network involving medial temporal, frontal, and parietal cortical regions.
Ruxue Gong, Xiaolong Peng, Rebecca W. Roth, Haris Rashid, William Yun, Daniel L. Drane, Leonardo Bonilha, Lisa McTeague, Ezequiel Gleichgerrcht   +8 more
wiley   +1 more source

Automated segmentation of postsurgical resection cavities on magnetic resonance imaging in focal epilepsy: A Multicentre Epilepsy Lesion Detection study

Epilepsia, EarlyView.
Abstract Objective Quantitative assessment of extent of tissue resection following epilepsy surgery requires accurate delineation of the resection cavity on postoperative magnetic resonance imaging (MRI). Current methods for resection cavity masking are time‐consuming and labor‐intensive, and existing automated approaches exhibit variable segmentation ...
Jieun Seo, Mathilde Ripart, Helene Kaas, Cornelius Kronlage, Ben Sinclair, Lucy Vivash, Merran R. Courtney, Terence J. O'Brien, Siby Gopinath, Harilal Parasuram, Sedat Kandemirli, Natally Alarab, Lillian Lai, Marcus Likeman, Kai Zhang, Jiajie Mo, Georgian Ciobotaru, James Galea, Philip Sequeiros‐Peggs, Khalid Hamandi, Hua Xie, Venkata Sita Priyanka Illapani, William D. Gaillard, Nathan T. Cohen, Alexander G. Weil, Florence Henrichon‐Goulet, Kenza S. Lahlou, Aristides Hadjinicolaou, Agustín Ibáñez, Gonzalo M. Rojas‐Costa, Horst Urbach, Lara Bücheler, Marcel Heers, Adrián Valls Carbó, Rafael Toledano, Giulia Nobile, Costanza Parodi, Domenico Tortora, Alessandro Consales, Antonella Riva, Mariasavina Severino, Martin Tisdall, Felice D'Arco, Kshitij Mankad, Aswin Chari, Maria H. Eriksson, Rory J. Piper, J. Helen Cross, Torsten Baldeweg, Sofia González‐Ortiz, Jose Pariente, Nuria Bargalló, Yawu Liu, Reetta Kälviäinen, Carmen Barba, Matteo Lenge, Renzo Guerrini, Masaki Iwasaki, Daichi Sone, Hiroyuki Maki, Tomoki Imokawa, Noriko Sato, Julien Jung, Francisco Sepulveda, Daniel Mansilla, Andres Goycoolea, Ingeborg Lopez, Antonio Napolitano, Alessandro De Benedictis, Luca De Palma, Maria Camilla Rossi‐Espagnet, Nikolaos Kondylidis, Kostakis Gkiatis, Kyriakos Garganis, Joshua Pepper, Stefano Seri, John S. Duncan, Clarissa L. Yasuda, Lucas Scárdua‐Silva, Marina K. M. Alvim, Fernando Cendes, Antonio G. Gennari, Ruth O'Gorman Tuura, Georgia Ramantani, Mariam Josyula, Joel Stein, Nishant Sinha, Kate Davis, R. Edward Hogan, Luigi Maccotta, Sophie Adler, Konrad Wagstyl   +91 more
wiley   +1 more source

Re‐evaluating impaired consciousness in temporal lobe epilepsy: The role of language dominance and network reorganization

Epilepsia, EarlyView.
Abstract Objective Temporal lobe epilepsy (TLE) frequently affects clinically‐classified ictal consciousness, which the 2025 International League Against Epilepsy (ILAE) classification operationalizes through clinical assessment of awareness and responsiveness.
Radheshyam Stepponat, Marc Berger, Laurin Schäfer, Laura Flamm, Kathrin Kollndorfer, Silvia Bonelli, Gregor Kasprian, Ekaterina Pataraia, Florian Ph. S. Fischmeister   +8 more
wiley   +1 more source

The Changing Landscape of Second Primary Malignancies in Multiple Myeloma: A SEER Population-Based Study Between Two Therapeutic Eras

Cancer Control
Introduction The introduction of proteasome inhibitors and immunomodulatory agents has significantly improved the prognosis of multiple myeloma (MM).
Weixiang Lu, Xiaoshan Huang, Shengyu Tian, Xiaojie Liang, Guanzhou Ke, Jia Guo, Qingqing Li, Yuquan Huang, Yang Li, Baiwei Luo, Bingyu Lin, Dan Xu, Liang Wang   +12 more
doaj   +1 more source

Novel planning pipeline utilizing the Surgical Theater system for pediatric epilepsy surgery

Epilepsia Open, EarlyView.
Abstract Objective Advances in the analysis and collation of radiographic datasets have enhanced presurgical planning for various neurosurgical procedures, including clipping of cerebral aneurysms, surgical resection of tumors, and arteriovenous malformation management.
Lisa B. E. Shields, Hunain Abri, Cemal Karakas, Shannon D. Davis, Ian S. Mutchnick   +4 more
wiley   +1 more source

Disrupted cerebellar networks in uncontrolled focal to bilateral tonic–clonic seizures

Epilepsia Open, EarlyView.
Abstract Objective Focal to bilateral tonic–clonic seizures (FBTC) are associated with significant morbidity and an elevated risk of sudden unexpected death in epilepsy (SUDEP). The cerebellum has been implicated in modulating the frequency and severity of tonic–clonic seizures.
John Phamnguyen, Elaine Kuan, Puneet Dheer, Viktor Vegh, David Reutens   +4 more
wiley   +1 more source