Results 1 to 10 of about 7,825,369 (248)

Onset of secondary progressive multiple sclerosis is not influenced by current relapsing multiple sclerosis therapies

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2018
Background Disease-modifying therapies are thought to reduce the conversion rate to secondary progressive multiple sclerosis. Objective To explore the rate, chronology, and contributing factors of conversion to the progressive phase in treated relapsing ...
Francisco Coret, Francisco C Pérez-Miralles, Francisco Gascón, Carmen Alcalá, Arantxa Navarré, Ana Bernad, Isabel Boscá, Matilde Escutia, Sara Gil-Perotin, Bonaventura Casanova   +9 more
doaj   +2 more sources

Elevated sCD40L in Secondary Progressive Multiple Sclerosis in Comparison to Non-progressive Benign and Relapsing Remitting Multiple Sclerosis

Journal of Central Nervous System Disease, 2021
Background: The long-term prognosis of relapsing-remitting multiple sclerosis (RRMS) is usually unfavorable as most patients transition to secondary progressive multiple sclerosis (SPMS) with accumulative disability.
Qi Wu, Qin Wang, Jennifer Yang, Jacob WS Martens, Elizabeth A Mills, Aiya Saad, Pavani Chilukuri, Catherine A Dowling, Yang Mao-Draayer   +8 more
doaj   +2 more sources

Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive Phenotype

Brain Sciences, 2022
Background: Cognitive deficits are common in multiple sclerosis (MS) and affect patients at all stages of the disease, regardless of phenotype. Aims: This literature review focuses the cognitive deficits observed in secondary progressive MS (SPMS). It is
Bruno Brochet, Pierre Clavelou, Gilles Defer, Jérôme De Seze, Céline Louapre, Eloi Magnin, Aurélie Ruet, Catherine Thomas-Anterion, Patrick Vermersch   +8 more
doaj   +3 more sources

Charles Bonnet Syndrome (CBS) in a Patient With Secondary Progressive Multiple Sclerosis: A Case Report [PDF]

Clinical Case Reports
Here we present a 69‐year‐old woman with Secondary Progressive Multiple Sclerosis (SPMS) and Charles Bonnet Syndrome. Our case underlines how clinicians should consider this rare syndrome in cognitively intact MS patients with visual hallucinations.
Shima Jahani, Atefeh Eidi Ardizi, MohammadAli Sahraian   +2 more
doaj   +2 more sources

Economic burden of secondary progressive multiple sclerosis: DISCOVER study [PDF]

BMC Health Services Research
Background To estimate the socioeconomic burden of people with secondary progressive multiple sclerosis (pwSPMS), considering direct health care, direct non-health care, and indirect costs, and to evaluate the relationship between costs and patients ...
Celia Oreja-Guevara, José E. Meca-Lallana, Irene Gómez-Estévez, José-Ramón Ara, Miguel Ángel Hernández Pérez, Julia Gracia Gil, Ana María Alonso Torres, Belén Pilo de la Fuente, Lluís Ramió-Torrentà, Sara Eichau Madueño, Francisco Gascón-Giménez, Bonaventura Casanova, Sergio Martínez-Yélamos, Marta Aguado Valcárcel, Maria Luisa Martínez Ginés, Yasmina El Berdei Montero, Ana María López Real, Vicente González-Quintanilla, Carlos Lopez de Silanes, José Enrique Martínez-Rodríguez, Lucienne Costa-Frossard, Moisés Garcés Redondo, Andrés Labiano Fontcuberta, Fernando Castellanos-Pinedo, Juan Antonio García Merino, Carmen Muñoz Fernández, Tamara Castillo-Triviño, Virginia Meca-Lallana, Joaquín Peña Martínez, Alfredo Rodríguez-Antigüedad, José María Prieto González, Eduardo Agüera Morales, Inmaculada Pérez Molina, Dulce M. Solar Sánchez, Nicolás Herrera Varo, Marta Aguirre Vázquez, José Manuel Rodríguez Barrios, Jordi Río   +37 more
doaj   +2 more sources

Rituximab in secondary progressive multiple sclerosis: a meta‐analysis [PDF]

Annals of Clinical and Translational Neurology
Objective To evaluate the efficacy of rituximab (RTX) in stabilizing disability progression in secondary progressive multiple sclerosis (SPMS). Methods A systematic review was conducted, encompassing studies from inception to April 2023, utilizing the ...
Pasin Intarakhao, Taksaporn Laipasu, Jiraporn Jitprapaikulsan, Natnasak Apiraksattayakul, Punchika Kosiyakul, Sasitorn Siritho, Naraporn Prayoonwiwat, Tatchaporn Ongphichetmetha   +7 more
doaj   +2 more sources

Can Multiple Sclerosis be Managed Over a Lifetime? A Rare 72‐Year Journey of Pediatric‐Onset to Secondary Progressive Multiple Sclerosis [PDF]

Clinical Case Reports
Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system characterized by cumulative neurological disability over time.
Masoud Etemadifar, Ahmadreza Dehghani, Mahdi Rahimi, Amirhossein Ghandehari, Mehri Salari   +4 more
doaj   +2 more sources

Guanidinoacetate–creatine in secondary progressive multiple sclerosis: a case report [PDF]

Journal of International Medical Research, 2022
Acute secondary progressive multiple sclerosis (SPMS) is characterized by escalating neurological disability, with limited disease-modifying therapeutic options.
Sergej M. Ostojic, Jelena Ostojic, Dragana Zanini, Tatjana Jezdimirovic, Valdemar Stajer   +4 more
doaj   +2 more sources

Brain reserve and physical disability in secondary progressive multiple sclerosis [PDF]

BMJ Neurology Open
Background The brain reserve hypothesis posits that larger maximal lifetime brain growth (MLBG) may confer protection against physical disability in multiple sclerosis (MS).
, Nevin John, Jeremy Chataway, Jacqueline Palace, Gavin Giovannoni, David Paling, Frederik Barkhof, Floriana De Angelis, Lorraine Smith, Thomas Williams, Martin Duddy, James Overell, Basil Sharrack, Sebastien Ourselin, Allan Walker, Siddharthan Chandran, Richard Nicholas, Shuna Colville, Peter Connick, Carolyn Young, Jeremy Hobart, Anisha Doshi, Sharmilee Gnanapavan, Helen Ford, Baljean Dhillon, Thanh Phan, Arman Eshaghi, Julia Aram, Nigel Stallard, James Cameron, Brendan McLean, Matthew Craner, Domenico Plantone, Jonathan Stutters, Ferran Prados Carrasco, Marie Braisher, Moira Ross, Gina Cranswick, Sue H Pavitt, Clive Hawkins, Roger Bastow, Daisy Mollison, Waqar Rashid, Joe Guadagno, Nikolaos Evangelou, Seema Kalra, Alberto Calvi, Yingtong Li, Tiggy Beyene, Vanessa Bassan, Alvin Zapata, Dawn Lyle, Heinke Arndt   +52 more
doaj   +2 more sources

Current challenges in secondary progressive multiple sclerosis: diagnosis, activity detection and treatment [PDF]

Frontiers in Immunology
Approximately 50% diagnosed with relapsing-remitting multiple sclerosis (RRMS) transition to secondary progressive multiple sclerosis (SPMS) within 20 years following disease onset.
Luis Brieva, Luis Brieva, Luis Brieva, Carmen Calles, Lamberto Landete, Celia Oreja-Guevara, Celia Oreja-Guevara   +6 more
doaj   +2 more sources