Results 1 to 10 of about 135,171 (118)

Frailty Exacerbates Disability in Progressive Multiple Sclerosis [PDF]

Annals of Clinical and Translational Neurology
Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53 ...
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
doaj   +2 more sources

Primary Progressive Multiple Sclerosis: New Therapeutic Approaches [PDF]

Neuropsychopharmacology Reports
Background and Purpose Primary progressive multiple sclerosis (PPMS) is a clinically different form of MS that causes gradual and irreversible neurological impairment from symptom onset without relapses or remissions. With a mean onset age of 37–43 years,
Morteza Rajabi, Sajjad Shafaeibajestan, Sevda Asadpour, Ghazal Alyari, Niloofar Taei, Moein Kohkalani, Ramin Raoufinia, Hamed Afarande, Ehsan Saburi   +8 more
doaj   +2 more sources

Impact of histone modifier-induced protection against autoimmune encephalomyelitis on multiple sclerosis treatment

Frontiers in Neurology, 2022
Multiple sclerosis is a progressive demyelinating central nervous system disorder with unknown etiology. The condition has heterogeneous presentations, including relapsing-remitting multiple sclerosis and secondary and primary progressive multiple ...
Sundararajan Jayaraman, Arathi Jayaraman
doaj   +1 more source

Clinical markers for unfavorable course of multiple sclerosis [PDF]

Анналы клинической и экспериментальной неврологии, 2023
Objective. To study possible clinical markers associated with the unfavorable course of multiple sclerosis and its transition to a progressive subtype. Materials and methods.
Mariya S. Matrosova, Galina N. Belskaya, Vasiliy V. Bryukhov, Ekaterina V. Popova, Marina V. Krotenkova   +4 more
doaj   +1 more source

Pain and participation in social activities in people with relapsing remitting and progressive multiple sclerosis

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2023
Background Differences in pain between subtypes of multiple sclerosis are understudied. Objective To compare the prevalence of pain, and the association between pain and: (a) pain interference and (b) social participation in people with relapsing ...
Dhruv Jain, Charles N Bernstein, Lesley A Graff, Scott B Patten, James M Bolton, John D Fisk, Carol Hitchon, James J Marriott, Ruth Ann Marrie,   +9 more
doaj   +1 more source

Deciphering Multiple Sclerosis Progression

Frontiers in Neurology, 2021
Multiple sclerosis (MS) is primarily an inflammatory and degenerative disease of the central nervous system, triggered by unknown environmental factors in patients with predisposing genetic risk profiles.
Virginia Meca-Lallana, Leticia Berenguer-Ruiz, Joan Carreres-Polo, Sara Eichau-Madueño, Jaime Ferrer-Lozano, Lucía Forero, Yolanda Higueras, Yolanda Higueras, Nieves Téllez Lara, Angela Vidal-Jordana, Francisco Carlos Pérez-Miralles, Francisco Carlos Pérez-Miralles   +11 more
doaj   +1 more source

Sensorimotor function in progressive multiple sclerosis

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2020
Background A sensitive test reflecting subtle sensorimotor changes throughout disease progression independent of mobility impairment is currently lacking in progressive multiple sclerosis. Objectives We examined non-ambulatory measures of upper and lower
Jules D Miehm, John Buonaccorsi, Jongil Lim, Sumire Sato, Caitlin Rajala, Julianna Averill, Farnaz Khalighinejad, Carolina Ionete, Stephanie L Jones, Jane A Kent, Richard EA van Emmerik   +10 more
doaj   +1 more source

Comparison of medical and social characteristics and quality of life of patients with primary- and secondary-progressive multiple sclerosis

Неврология, нейропсихиатрия, психосоматика, 2021
Management of patients with secondary progressive multiple sclerosis (SPMS) remains one of the most challenging tasks of modern neurology. Patients with SPMS present with more severe neurological symptoms, increased hospitalization frequency, pronounced ...
Ya. V. Vlasov, N. G. Polyarnaya, A. N. Boyko   +2 more
doaj   +1 more source

Treatment Patterns and Unmet Need for Patients with Progressive Multiple Sclerosis in the United States: Survey Results from 2016 to 2021

Neurology and Therapy, 2023
Introduction Much of the current literature on treatment patterns and disability progression in multiple sclerosis (MS) does not distinguish between the relapsing–remitting and progressive subtypes (including primary [PPMS] and secondary progressive MS ...
Crystal Watson, Dhanalakshmi Thirumalai, Arie Barlev, Eddie Jones, Sasha Bogdanovich, Kiren Kresa-Reahl   +5 more
doaj   +1 more source

Primary progressive multiple sclerosis in the Polish population

Aktualności Neurologiczne, 2017
Objectives: The aim of the study was the epidemiological analysis and evaluation of selected clinical and sociodemographic factors in Polish patients with primary progressive multiple sclerosis.
Waldemar Brola, Piotr Sobolewski, Stanisław Flaga, Małgorzata Fudala, Andrzej Potemkowski   +4 more
doaj   +1 more source