Results 41 to 50 of about 5,411,820 (260)

Elevated sCD40L in Secondary Progressive Multiple Sclerosis in Comparison to Non-progressive Benign and Relapsing Remitting Multiple Sclerosis

Journal of Central Nervous System Disease, 2021
Background: The long-term prognosis of relapsing-remitting multiple sclerosis (RRMS) is usually unfavorable as most patients transition to secondary progressive multiple sclerosis (SPMS) with accumulative disability.
Qi Wu, Qin Wang, Jennifer Yang, Jacob WS Martens, Elizabeth A Mills, Aiya Saad, Pavani Chilukuri, Catherine A Dowling, Yang Mao-Draayer   +8 more
doaj   +1 more source

Patterns of care for Multiple Sclerosis in a setting of universal care access: A cross-sectional study [PDF]

, 2019
BACKGROUND Current guidelines recommend regular neurological MS care in persons diagnosed with MS, but little is known about implementation of this recommendation or potential access barriers.
Rodgers, S., Kaufmann, Marco; https://orcid.org/, Kuhle, J., Puhan, M.A., Puhan, Milo A, Kuhle, Jens, Puhan, M. A., Kamm, Christian P, Kesselring, Jürg, Rodgers, Stephanie, Pot, Caroline, von Wyl, Viktor, Czaplinski, Adam, Barin, L., Kamm, C.P., von Wyl, V., Barin, Laura, Salmen, A., Ajdacic-Gross, Vladeta, Pot, C., Salmen, Anke, Kaufmann, M., Chan, A., Czaplinski, A., Kamm, Christian P., Swiss Multiple Sclerosis Registry, Chan, Andrew, Gobbi, C., Ajdacic-Gross, V., Gobbi, Claudio, Kesselring, J.   +30 more
core   +1 more source

Toxocara infection in the differential diagnosis of multiple sclerosis in the Middle East [PDF]

, 2020
A critical step in the diagnosis of multiple sclerosis is to rule out a heterogeneous variety of multiple sclerosis mimickers, which is crucial in the era of powerful immune-modulator treatments.
El Najjar, Mayssam, El-Ayoubi, Nabil K., Atweh, Samir F., Baalbaki, Marwa M.   +3 more
core   +1 more source

Axonal damage accumulates in the progressive phase of multiple sclerosis: three year follow up study [PDF]

, 2005
BACKGROUND: Neurofilament phosphoforms (Nf) are principal components of the axoskeleton released during axonal injury. Cerebrospinal fluid (CSF) levels of Nf phosphoforms might be useful surrogate markers for disability in multiple sclerosis (MS), aid in
Polman, C.H., Grant, D., Uitdehaag, B.M.J., Lazeron, R.H., Eikelenboom, M.J., Petzold, A., Thompson, E.J., Keir, G., Giovannoni, G., Lazeron, R.H.C.   +9 more
core   +1 more source

Enhancing patients’ role in scientific writing: insights from a global participatory approach with people with multiple sclerosis

Research Involvement and Engagement
Introduction This study aims to describe a participatory process by investigating the perceptions and expectations of people with multiple sclerosis (pwMS) toward the scientific writing (SW) process and the role of patient engagement and quality of life ...
Mariarosaria Savarese, Dilara Usta, Federico Bozzoli, Vanessa Fanning, Federica Molinari, Guendalina Graffigna, Paola Zaratin   +6 more
doaj   +1 more source

Perception of stigma in patients with primary progressive multiple sclerosis

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2019
Stigma associated with neurological disorders may contribute to a poor health-related quality of life. However, limited information is available in primary progressive multiple sclerosis. We investigated the presence and impact of stigma in patients with
Francisco Pérez-Miralles, Daniel Prefasi, Antonio García-Merino, José R Ara, Guillermo Izquierdo, Virginia Meca-Lallana, Francisco Gascón, María L Martínez-Ginés, Lluis Ramió-Torrentà, Lucienne Costa-Frossard, Óscar Fernández, Sara Moreno-García, Jorge Maurino, Bonaventura Casanova-Estruch   +13 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Stem Cell Therapies for Progressive Multiple Sclerosis

Frontiers in Cell and Developmental Biology, 2021
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. MS patients typically present with a relapsing-remitting (RR) disease course, manifesting as sporadic attacks ...
Jayden A. Smith, Alexandra M. Nicaise, Rosana-Bristena Ionescu, Regan Hamel, Luca Peruzzotti-Jametti, Stefano Pluchino   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial

Health Technology Assessment
Background Despite the relative success of immuno-modulatory disease-modifying therapy in relapsing remitting multiple sclerosis, progressive worsening of disability remains a major problem, particularly for those with secondary progressive multiple ...
Thomas Williams, James Blackstone, Nevin John, Marie Braisher, Floriana De Angelis, Alessa Bianchi, Alberto Calvi, Anisha Doshi, Sean Apap Mangion, Charles Wade, Ekaterina Bordea, Rachel Merry, Gil Barton, Dawn Lyle, Elisabeth Jarman, Don Mahad, Abdullah Shehu, Tarunya Arun, Gavin McDonnell, Ruth Geraldes, Matthew Craner, Charles Hillier, Jeban Ganesalingam, Leonora Fisniku, Jeremy Hobart, Cord Spilker, Neil P Robertson, Seema Kalra, Stefano Pluchino, Sreedharan Harikrishnan, Miriam Mattoscio, Timothy Harrower, Carolyn Young, Martin Lee, Suresh Kumar Chhetri, Fayyaz Ahmed, David Rog, Eli Silber, Paul Gallagher, Martin Duddy, Agne Straukiene, Richard Nicholas, Claire Rice, Susan Tebbs, Annie Hawton, Rachael Hunter, Gavin Giovannoni, Olga Ciccarelli, Judy Beveridge, Stuart Nixon, Alan J Thompson, John Greenwood, Owen Pearson, Nikos Evangelou, Basil Sharrack, Ian Galea, Sue Pavitt, Siddharthan Chandran, Helen L Ford, Jennifer M Nicholas, Jeremy Chataway   +60 more
doaj   +1 more source