SUMMIT (Serially Unified Multicenter Multiple Sclerosis Investigation): creating a repository of deeply phenotyped contemporary multiple sclerosis cohorts. [PDF]
BackgroundThere is a pressing need for robust longitudinal cohort studies in the modern treatment era of multiple sclerosis.ObjectiveBuild a multiple sclerosis (MS) cohort repository to capture the variability of disability accumulation, as well as ...
Uitdehaag, Bernard M.J. +18 more
core +1 more source
Consensus recommendations for the diagnosis and treatment of multiple sclerosis: 2019 revisions to the MENACTRIMS guidelines [PDF]
With evolving diagnostic criteria and the advent of new oral and parenteral therapies for MS, most current diagnostic and treatment algorithms need revision and updating.
Almahdawi, Akram M. +18 more
core +1 more source
Introduction Patients with multiple sclerosis commonly show some degree of psychiatric symptoms. Primary progressive multiple sclerosis is a part of the spectrum of multiple sclerosis phenotypes with progressive accumulation of disability from disease ...
Zui Narita +3 more
doaj +1 more source
Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]
Multiple sclerosis is an immune-mediated, demyelinating and neurodegenerative disease that currently lacks any neuroprotective treatments. Innovative neuroprotective trial designs are required to hasten the translational process of drug development.
Coffey, P +31 more
core +1 more source
Multiple Sclerosis Relapsing Remitting Progressive Type
Multiple sclerosis (MS) is the most common neurologic demyelinating disease in high-income countries. The causes of MS is multifactorial involve genetics and the environment in which immune cell infiltration occurs across the blood-brain barrier, causing
Nora Fitri +2 more
doaj +1 more source
Serum neurofilament light and MRI predictors of cognitive decline in patients with secondary progressive multiple sclerosis: Analysis from the MS-STAT randomised controlled trial [PDF]
Magnetic resonance imaging; Neurofilament light; Secondary progressive multiple sclerosisImatge per ressonància magnètica; Llum del neurofilament; Esclerosi múltiple secundària progressivaImagen por resonancia magnética; Luz de neurofilamento; Esclerosis
Doshi, Anisha +5 more
core +1 more source
Anti-SARS-CoV-2 vaccination in people with multiple sclerosis: Lessons learnt a year in
It has been over a year since people with multiple sclerosis (pwMS) have been receiving vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With a negligible number of cases in which vaccination led to a relapse or new onset MS,
Maura Pugliatti +22 more
doaj +1 more source
Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?
Background Progressive solitary sclerosis is a unifocal demyelinating disease recently proposed as a possible multiple sclerosis variant. Objective To compare myelin content and brain metabolite ratio qualitatively in the normal-appearing white matter of
Lisa Eunyoung Lee +12 more
doaj +1 more source
Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study
Background Treatment options for patients suffering from progressive forms of multiple sclerosis (MS) remain inadequate. Mast cells actively participate in the pathogenesis of MS, in part because they release large amounts of various mediators that ...
Vermersch Patrick +8 more
doaj +1 more source
Experience of Identity Change in People Who Reported a Diagnosis of Multiple Sclerosis : A Qualitative Inquiry [PDF]
Background: A diagnosis of multiple sclerosis (MS) can lead to changes to a person’s sense of self. The aim of this study was to investigate the subjective experience of identity change and subsequent adjustment to MS.
das Nair, Roshan +13 more
core +1 more source

