Results 31 to 40 of about 5,411,820 (260)

Onset of secondary progressive multiple sclerosis is not influenced by current relapsing multiple sclerosis therapies

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2018
Background Disease-modifying therapies are thought to reduce the conversion rate to secondary progressive multiple sclerosis. Objective To explore the rate, chronology, and contributing factors of conversion to the progressive phase in treated relapsing ...
Francisco Coret, Francisco C Pérez-Miralles, Francisco Gascón, Carmen Alcalá, Arantxa Navarré, Ana Bernad, Isabel Boscá, Matilde Escutia, Sara Gil-Perotin, Bonaventura Casanova   +9 more
doaj   +1 more source

Assessment of sexual life and social life in people with multiple sclerosis

Health Promotion & Physical Activity, 2022
Introduction: Multiple sclerosis is a debilitating condition that affects the central nervous system and is most common in young people. Over time, the relapses associated with the disease can cause damage, and within ten years of onset, half of patients
Denis Arsovski
doaj   +1 more source

Radiologically isolated syndrome and multiple sclerosis [PDF]

, 2017
Background Incidental white matter lesions (WML) are increasingly seen on brain magnetic resonance imaging (MRI) in clinical practice. Demyelination consistent with MS is seen in 0.1–0.7% of the population as evident by autopsy and MRI studies.
AlKhawajah, Mona Marwan, B. Yamout, M. Al Khawajah, Yamout, Bassem I.   +3 more
core   +1 more source

Pathogenic Microglia Orchestrate Neurotoxic Properties of Eomes-Expressing Helper T Cells

Cells, 2023
In addition to disease-associated microglia (DAM), microglia with MHC-II and/or IFN-I signatures may form additional pathogenic subsets that are relevant to neurodegeneration. However, the significance of such MHC-II and IFN-I signatures remains elusive.
Chenyang Zhang, Ben Raveney, Fumio Takahashi, Tzu-wen Yeh, Hirohiko Hohjoh, Takashi Yamamura, Shinji Oki   +6 more
doaj   +1 more source

Risk of secondary progressive multiple sclerosis: A longitudinal study.

, 2020
BACKGROUND: The risk factors for conversion from relapsing-remitting to secondary progressive multiple sclerosis remain highly contested. OBJECTIVE: The aim of this study was to determine the demographic, clinical and paraclinical features that influence
Jun, Jae-Kwan, Spelman, Tim, Pucci, Eugenio, Verheul, Freek, Fragoso, Yara, Yamout, Bassem, Al-Harbi, Talal, Bergamaschi, Roberto, Gray, Orla, Butzkueven, Helmut, Prat, Alexandre, Turkoglu, Recai, McCombe, Pamela, Grand'Maison, Francois, Lugaresi, Alessandra, Alroughani, Raed, Terzi, Murat, Petersen, Thor, Slee, Mark, Shaw, Cameron, Hughes, Jordana, Barnett, Michael, Moore, Fraser, Trojano, Maria, Vucic, Steve, Olascoaga, Javier, Horakova, Dana, Saladino, Maria Laura, Altintas, Ayse, Sanchez-Menoyo, Jose Luis, Deri, Norma, Kubala Havrdova, Eva, Skibina, Olga, Ozakbas, Serkan, Iuliano, Gerardo, Cristiano, Edgardo, Taylor, Bruce, Ferraro, Diana, Fambiatos, Adam, Izquierdo, Guillermo, Van Pesch, Vincent, Ampapa, Radek, Van Wijmeersch, Bart, Lechner-Scott, Jeannette, Granella, Franco, Sidhom, Youssef, Boz, Cavit, Hupperts, Raymond, Spitaleri, Daniele, Girard, Marc, Solaro, Claudio, Duquette, Pierre, Soysal, Aysun, Singhal, Bhim, Shuey, Neil, Hodgkinson, Suzanne, Csepany, Tunde, Havrdova, Eva Kubala, Jokubaitis, Vilija, Prevost, Julie, Grammond, Pierre, Kalincik, Tomas, Sola, Patrizia, van der Walt, Anneke   +63 more
core   +1 more source

Periventricular gradient of T1 tissue alterations in multiple sclerosis

NeuroImage: Clinical, 2022
Objective: Pathology in multiple sclerosis is not homogenously distributed. Recently, it has been shown that structures adjacent to CSF are more severely affected.
Manuela Vaneckova, Gian Franco Piredda, Michaela Andelova, Jan Krasensky, Tomas Uher, Barbora Srpova, Eva Kubala Havrdova, Karolina Vodehnalova, Dana Horakova, Tom Hilbert, Bénédicte Maréchal, Mário João Fartaria, Veronica Ravano, Tobias Kober   +13 more
doaj   +1 more source

Evaluation of cognitive assessment and cognitive intervention for people with multiple sclerosis [PDF]

, 2002
Objectives: Cognitive problems in multiple sclerosis are common but any possible benefits of treatment remain uncertain. The aim of the study was to evaluate the benefits of providing a psychology service, including cognitive assessment and intervention,
Weyman, N., Blumhardt, L. D., Blumhardt, L.D., Harding, J., Lincoln, N. B., Dent, A., Nicholl, C., Lincoln, N.B., Playford, E.D., Playford, E. Diane   +9 more
core   +1 more source

Quantification of cerebral tissue volumes in multiple sclerosis: global and regional analysis [PDF]

, 2006
Brain atrophy has been reported in multiple sclerosis (MS). We addressed the question of GM and WM tissue loss in a large population of 597 patients with multiple sclerosis (MS) compared with 104 control subjects using a fully automated, operator ...
Prinster, Anna
core   +1 more source

Systematic literature review and meta-analysis of the prevalence of secondary progressive multiple sclerosis in the USA, Europe, Canada, Australia, and Brazil

BMC Neurology, 2022
Background Secondary progressive multiple sclerosis (SPMS) is a subtype of multiple sclerosis (MS), which is a chronic neurological disease, characterised by inflammation of the central nervous system.
Vijayalakshmi Vasanthaprasad, Vivek Khurana, Sreelatha Vadapalle, Jackie Palace, Nicholas Adlard   +4 more
doaj   +1 more source

Assessment of potential cardiotoxic side effects of mitoxantrone in patients with multiple sclerosis [PDF]

, 2005
Previous studies showed that mitoxantrone can reduce disability progression in patients with multiple sclerosis (MS). There is, however, concern that it may cause irreversible cardiomyopathy with reduced left ventricular (LV) ejection fraction (EF) and ...
Zingler, V. C., Hohlfeld, R., Strupp, M., Brandt, T., Jahn, K., Näbauer, M., Gross, A.   +6 more
core   +1 more source