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Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive Phenotype

open access: yesBrain Sciences, 2022
Background: Cognitive deficits are common in multiple sclerosis (MS) and affect patients at all stages of the disease, regardless of phenotype. Aims: This literature review focuses the cognitive deficits observed in secondary progressive MS (SPMS). It is
Bruno Brochet   +8 more
doaj   +3 more sources

Extracellular Vesicle-Associated miRNA in Multiple Sclerosis Subtypes: Differential Profiles in Secondary Progressive Disease and the Effect of One-Year Siponimod Treatment [PDF]

open access: yesCells
Circulating extracellular vesicle-associated microRNAs (EV-miRNAs) are emerging as promising peripheral biomarkers in multiple sclerosis (MS). This prospective, observational pilot study was conceived as a hypothesis-generating investigation to ...
Oana Vrînceanu   +4 more
doaj   +2 more sources

Economic burden of secondary progressive multiple sclerosis: DISCOVER study [PDF]

open access: yesBMC Health Services Research
Background To estimate the socioeconomic burden of people with secondary progressive multiple sclerosis (pwSPMS), considering direct health care, direct non-health care, and indirect costs, and to evaluate the relationship between costs and patients ...
Celia Oreja-Guevara   +37 more
doaj   +2 more sources

Rituximab in secondary progressive multiple sclerosis: a meta‐analysis [PDF]

open access: yesAnnals of Clinical and Translational Neurology
Objective To evaluate the efficacy of rituximab (RTX) in stabilizing disability progression in secondary progressive multiple sclerosis (SPMS). Methods A systematic review was conducted, encompassing studies from inception to April 2023, utilizing the ...
Pasin Intarakhao   +7 more
doaj   +2 more sources

Elevated sCD40L in Secondary Progressive Multiple Sclerosis in Comparison to Non-progressive Benign and Relapsing Remitting Multiple Sclerosis

open access: yesJournal of Central Nervous System Disease, 2021
Background: The long-term prognosis of relapsing-remitting multiple sclerosis (RRMS) is usually unfavorable as most patients transition to secondary progressive multiple sclerosis (SPMS) with accumulative disability.
Qi Wu   +8 more
doaj   +2 more sources

Radiotherapy Improves the Disability in Patients with Secondary Progressive Multiple Sclerosis [PDF]

open access: yesJournal of Biomedical Physics and Engineering, 2023
Background: Multiple sclerosis (MS) as a complex neurological abnormality is marked with loss of myelin and axons due to chronic inflammatory and autoimmune responses.
Hossein-Ali Ebrahimi   +3 more
doaj   +2 more sources

Clinical Evaluation of Siponimod for the Treatment of Secondary Progressive Multiple Sclerosis: Pathophysiology, Efficacy, Safety, Patient Acceptability and Adherence

open access: yesPatient Preference and Adherence, 2022
Sajida Sabsabi,1 Elio Mikhael,2 Georges Jalkh,1 Gabrielle Macaron,1,3 Mary Rensel3 1Department of Neurology, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon; 2Department of Internal Medicine, Hotel Dieu de France Hospital, Saint ...
Sabsabi S   +4 more
doaj   +2 more sources

Brain reserve and physical disability in secondary progressive multiple sclerosis [PDF]

open access: yesBMJ Neurology Open
Background The brain reserve hypothesis posits that larger maximal lifetime brain growth (MLBG) may confer protection against physical disability in multiple sclerosis (MS).
  +52 more
doaj   +2 more sources

Advances in clinical diagnosis of secondary progressive multiple sclerosis [PDF]

open access: yesZhenduanxue lilun yu shijian, 2022
Multiple sclerosis(MS) is a chronic inflammatory disease of the central nervous system that involves demyelination and axonal degeneration. Usually, MS begins with a relapsing-remitting MS (RRMS) course, and approxi mately will develop into secondary ...
ZHANG Chao, GAO Xue
doaj   +1 more source

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