Results 21 to 30 of about 3,980,763 (249)

Can we treat secondary progressive multiple sclerosis now?

Annals of Indian Academy of Neurology, 2019
Secondary progressive multiple sclerosis (SPMS) is characterized by progressive accumulation of disability without intermittent recovery. Treatment of these patients is challenging due to limited understanding of pathogenesis and fewer therapeutic ...
Rohit Bhatia, Nishita Singh
doaj   +1 more source

Guanidinoacetate–creatine in secondary progressive multiple sclerosis: a case report

Journal of International Medical Research, 2022
Acute secondary progressive multiple sclerosis (SPMS) is characterized by escalating neurological disability, with limited disease-modifying therapeutic options.
Sergej M. Ostojic, Jelena Ostojic, Dragana Zanini, Tatjana Jezdimirovic, Valdemar Stajer   +4 more
doaj   +1 more source

Case Report: Progressive Asymmetric Parkinsonism Secondary to CADASIL Without Dementia

Frontiers in Neurology, 2022
Parkinsonism is a rare phenotype of cerebral autosomal dominant arteriopathy with subcortical infarction and leukoencephalopathy (CADASIL), all of which involve cognitive decline. Normal cognition has not been reported in previous disease studies.
Weihang Guo, Baolei Xu, Baolei Xu, Baolei Xu, Baolei Xu, Hong Sun, Hong Sun, Hong Sun, Hong Sun, Jinghong Ma, Jinghong Ma, Jinghong Ma, Jinghong Ma, ShanShan Mei, ShanShan Mei, ShanShan Mei, ShanShan Mei, Jingrong Zeng, Junyan Sun, Junyan Sun, Erhe Xu, Erhe Xu, Erhe Xu, Erhe Xu   +23 more
doaj   +1 more source

Hemophagocytic lymphohistiocytosis secondary to progressive disseminated histoplasmosis presenting as cellulitis

Medical Mycology Case Reports, 2021
Histoplasmosis-associated hemophagocytic lymphohistiocytosis is a rate but lethal disease in immunocompromised hosts. Unusual clinical presentations make diagnosing invasive fungal infection even more challenging. Here we present a case of hemophagocytic
Alfredo G. Puing, Shyam S. Raghavan, Maria A. Aleshin, Dora Y. Ho   +3 more
doaj   +1 more source

Comparing power and activity of lower body muscles in two types of multiple sclerosis patients and healthy individuals

Fiyz̤, 2020
Background: Multiple sclerosis (MS) is a chronic and debilitating disorder that renders degeneration of myelin within Central Nervous System (CNS). This study aimed to investigate the strength and muscle activity in two models of patients with multiple ...
Talebi V, Fallah-Mohammadi Z, Saadat P, Hosseini-Nejad SE   +3 more
doaj  

Progressive Fatal Myelopathy Secondary to Isolated Spinal Cord Vasculitis

Frontiers in Neurology, 2017
A 56-year-old woman with various neurological signs which developed over a 1-year period was admitted for evaluation. MRI showed a markedly abnormal signal in the cervical spine. Despite treatment with IV steroids, she developed a progressive myelopathy,
Arie Fisher, Habib Rahman, Michael Farrell, Michael Hennessy   +3 more
doaj   +1 more source

Bowel obstruction and perforation secondary to progressive heterotopic mesenteric ossificans

Radiology Case Reports, 2022
Heterotopic mesenteric ossification (HMO) is a rare condition which usually affects male patients. Its defining feature is hyperdense ossification in the mesentery, usually following surgery or trauma.
Emily M. Louis, Savvas Nicolaou, MD
doaj   +1 more source

Disease Course After Anti-CD20 Discontinuation in Secondary Progressive Multiple Sclerosis-A Multicenter Long-Term Longitudinal Study. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Otto F, Kliushnikova D, Radlberger RF, Yasaroglu S, Moser T, Harrer A, Kratzer K, Hitzl W, Gradl C, Schmidauer M, Roth P, Hegen H, Wipfler P.   +12 more
europepmc   +2 more sources

Comparative efficacy and tolerability of ublituximab vs. other monoclonal antibodies in the treatment of relapsing multiple sclerosis: a systematic review and network meta-analysis of randomized trials

Frontiers in Neurology
BackgroundRelapsing multiple sclerosis (RMS) is a chronic, inflammatory disease of the central nervous system. Ublituximab, an anti-CD20 monoclonal antibody (mAb), is indicated for the treatment of RMS.
Eoin Moloney, Atefeh Mashayekhi, Sakshi Sharma, Vasileios Kontogiannis, Amir Ansaripour, Wallace Brownlee, Wallace Brownlee, David Paling, Mehdi Javanbakht   +8 more
doaj   +1 more source

Secondary bending effects in progressively damaged single-lap, single-bolt composite joints

Results in Physics, 2016
Static tensile experiments and progressive failure simulations of single-bolt, single- and double-lap joints were carried out to comparatively investigate secondary bending effects, which present significant eccentric-loading phenomena in single-lap ...
Libin Zhao, An Xin, Fengrui Liu, Jianyu Zhang, Ning Hu   +4 more
doaj   +1 more source