Results 1 to 10 of about 151,084 (348)

Efficacy and safety of upadacitinib for active ankylosing spondylitis refractory to biological therapy: a double-blind, randomised, placebo-controlled phase 3 trial

Annals of the Rheumatic Diseases, 2022
Objectives To evaluate the efficacy and safety of upadacitinib, a Janus kinase inhibitor, in patients with active ankylosing spondylitis (AS) with an inadequate response (IR) to biological disease-modifying antirheumatic drugs (bDMARDs).
D. van der Heijde, X. Baraliakos, J. Sieper, A. Deodhar, R. Inman, H. Kameda, Xiaofeng Zeng, Y. Sui, X. Bu, A. Pangan, P. Wung, I. Song   +11 more
semanticscholar   +1 more source

Long-term Safety of Secukinumab Over Five Years in Patients with Moderate-to-severe Plaque Psoriasis, Psoriatic Arthritis and Ankylosing Spondylitis: Update on Integrated Pooled Clinical Trial and Post-marketing Surveillance Data

Acta Dermato-Venereologica, 2022
Secukinumab, a selective interleukin (IL)-17A inhibitor, is approved for use in adult and paediatric psoriasis, psoriatic arthritis, ankylosing spondylitis and non-radiographic axial spondyloarthritis.
A. Gottlieb, A. Deodhar, I. McInnes, X. Baraliakos, K. Reich, S. Schreiber, W. Bao, K. Marfo, H. Richards, L. Pricop, A. Shete, V. Trivedi, Deborah Keefe, C. Papavassilis, P. Jagiello, P. Papanastasiou, P. Mease, M. Lebwohl   +17 more
semanticscholar   +1 more source

Biology and therapeutic potential of mesenchymal stem cell extracellular vesicles in axial spondyloarthritis

Communications Biology, 2023
Axial spondyloarthritis (AxSpA) is a chronic, inflammatory, autoimmune disease that predominantly affects the joints of the spine, causes chronic pain, and, in advanced stages, may result in spinal fusion.
Fataneh Tavasolian, Robert D. Inman
doaj   +1 more source

Systemic immune‐inflammation index is associated with disease activity in patients with ankylosing spondylitis

Journal of clinical laboratory analysis (Print), 2021
The systemic immune‐inflammation index (SII) is a recently developed indicator for systemic inflammatory response. We aimed to explore the association between SII and disease activity in patients with ankylosing spondylitis (AS).
Junlai Wu, Lifang Yan, K. Chai
semanticscholar   +1 more source

HLA-B27 is associated with reduced disease activity in axial spondyloarthritis

Scientific Reports, 2021
HLA-B27 is associated with increased susceptibility and disease activity of ankylosing spondylitis, but the effect of HLA-B27 on the activity of the broader category now called axial spondyloarthritis (AxSpA) is apparently the opposite.
James T. Rosenbaum, Michael H. Weisman, Hedley Hamilton, Cassie Shafer, Elin Aslanyan, Richard A. Howard, Kimberly Ogle, John D. Reveille, Kevin L. Winthrop, Dongseok Choi   +9 more
doaj   +1 more source

TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis

Nature Communications, 2021
Ankylosing spondylitis (AS) is a type of rheumatic disease characterized by chronic inflammation and pathological osteogenesis in the entheses. Previously, we demonstrated that enhanced osteogenic differentiation of MSC from AS patients (AS-MSC) resulted
Zhongyu Xie, Wenhui Yu, Guan Zheng, Jinteng Li, Shuizhong Cen, Guiwen Ye, Zhaofeng Li, Wenjie Liu, Ming Li, Jiajie Lin, Zepeng Su, Yunshu Che, Feng Ye, Peng Wang, Yanfeng Wu, Huiyong Shen   +15 more
semanticscholar   +1 more source

Candidal Vertebral Osteomyelitis in the Midst of Renal Disorders [PDF]

Journal of Clinical and Diagnostic Research, 2016
Vertebral osteomyelitis also known as discitis/pyogenic spondylitis refers to inflammation of the vertebral disc space. It is commonly seen in men and adults more than 50 years of age.
Anusha Gopinathan, Anil Kumar, Srivatsa Nagaraja Rao, Krishna Kumar, Shamsul Karim   +4 more
doaj   +1 more source

Clinical profile, diagnosis, treatment, and outcome of patients with tubercular versus nontubercular causes of spine involvement: A retrospective cohort study from India

International Journal of Mycobacteriology, 2022
Background: In tuberculosis (TB) endemic areas, other pyogenic causes of spine involvement may be missed. The study aimed to describe TB and non-TB causes of spine involvement and identify features that can help in differentiating them.
Nitin Gupta, Shyamasunder N Bhat, Suhas Reddysetti, M A Afees Ahamed, Divya Jose, Aravind Srivatsa Sarvepalli, Sowmya Joylin, Vishwapriya M Godkhindi, Ali A Rabaan, Kavitha Saravu   +9 more
doaj   +1 more source

Inflammasome Activation in Ankylosing Spondylitis Is Associated With Gut Dysbiosis

Arthritis & Rheumatology, 2021
We undertook this study to evaluate the activation and functional relevance of inflammasome pathways in ankylosing spondylitis (AS) patients and rodent models and their relationship to dysbiosis.
G. Guggino, D. Mauro, A. Rizzo, R. Alessandro, S. Raimondo, A. Bergot, M. A. Rahman, Jonathan J. Ellis, S. Milling, R. Lories, D. Elewaut, Matthew A Brown, Ranjeny Thomas, F. Ciccia   +13 more
semanticscholar   +1 more source

Diagnosis of Spinal Infection with Alpha-defensin Lateral Flow Test: A Preliminary Report

Spine Surgery and Related Research, 2022
Introduction: The alpha-defensin lateral flow test has been used in periprosthetic joint infection as a diagnostic support tool because of its simplicity and speed. However, the test has not been used to diagnose spinal infections.
Atsuhiro Yoshida, Tsutomu Akazawa, Yoshiaki Torii, Jun Ueno, Masahiro Iinuma, Hisateru Niki   +5 more
doaj   +1 more source