Results 161 to 170 of about 63,268 (276)

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

open access: yesiNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong   +5 more
wiley   +1 more source

Synovial Fluid Biomarkers Reflect Pre‐ and Postoperative Clinical Features in Rotator Cuff Tears, Independent of Tear Size

open access: yesJournal of Orthopaedic Research, Volume 44, Issue 6, June 2026.
ABSTRACT Synovitis is a major contributor to pain and dysfunction in rotator cuff tears (RCTs), yet it remains unclear whether routine synovial fluid (SF) parameters reflect clinical features independent of tear size, operation method, and patient age.
Seungmin Jeong   +3 more
wiley   +1 more source

Patients With Chronic Low Back Pain Without Advanced Disk Degeneration Exhibit Gut Microbiome Dysbiosis: Evidence From an Age‐, Sex‐, and BMI‐Matched Pilot Study

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
Chronic low back pain in patients without advanced disc degeneration is associated with gut microbiome dysbiosis, marked by reduced microbial diversity and altered bacterial composition. These findings support a gut–disk axis in which impaired gut barrier integrity and systemic inflammation may contribute to disc inflammation, nociceptive fiber ...
Stone Sima   +10 more
wiley   +1 more source

Explainable Supervised Learning Classification Model Using Diffusion Tensor Imaging Predicts Postoperative Outcomes in Cervical Spondylotic Myelopathy: A Preliminary Study

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
ABSTRACT Background Cervical spondylotic myelopathy (CSM) is common in older adults. Some patients may experience incomplete neurological recovery after surgery, or even deterioration. Accurate prognosis is essential for patients, yet current tools use subjective scores and fail to detect early spinal cord microstructural changes.
Yifei Peng   +6 more
wiley   +1 more source

Clinical Features and Therapeutic Outcomes in Pyoderma Gangrenosum: A Prospective Cohort Study

open access: yesJEADV Clinical Practice, Volume 5, Issue 2, Page 495-501, June 2026.
ABSTRACT Background Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis highly associated with systemic comorbidities. Accurate diagnosis and treatment remain challenging due to its rarity and clinical mimickers. Objectives To evaluate demographic, clinical features and treatment outcomes in patients referred with suspected PG at a tertiary ...
David Croitoru   +13 more
wiley   +1 more source

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