Spondylitis - Open Access .click

Results 71 to 80 of about 118,506 (311)

An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes [PDF]

, 2018
The Endoplasmatic Reticulum Aminopeptidases ERAP1 and ERAP2 are implicated in a variety of immune and non-immune functions. Most studies however have focused on their role in shaping the HLA class I peptidome by trimming peptides to the optimal size ...
Cauli, A +7 more
core +2 more sources

High‐resolution deep learning DIXON MRI of the sacroiliac joints is non‐inferior to standard MRI in patients with suspected axial Spondyloarthritis

Arthritis &Rheumatology, Accepted Article.
Objective To compare the standard multi‐sequence MRI protocol (sMRI) of the sacroiliac joints with a single high‐resolution deep learning–reconstructed DIXON sequence (DL‐DIXON) in patients with suspected axial spondyloarthritis (axSpA). Methods Seventy‐six patients with chronic low back pain and suspected axSpA underwent clinical, laboratory, and ...
Dominik Deppe +12 more
wiley +1 more source

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis [PDF]

, 2017
Background: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied.
Alessandro, Riccardo +13 more
core +2 more sources

Determinants of Difficult‐to‐Manage and Treatment‐Refractory Axial Spondyloarthritis: A Cross‐Sectional Analysis within a Longitudinal Cohort

Arthritis &Rheumatology, Accepted Article.
Objective To estimate the prevalence of difficult‐to‐manage (D2M) and treatment‐refractory (TR) axSpA and to identify factors associated with D2M/TR disease in a longitudinal cohort. Methods We performed a cross‐sectional analysis on data from the Schroeder Arthritis Institute Spondylitis Program cohort.
Patricia Remalante‐Rayco +8 more
wiley +1 more source

Higher complement C4 gene copy number constitutes a shared genetic risk factor for giant cell arteritis and IgA vasculitis

Arthritis &Rheumatology, Accepted Article.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +296 more
wiley +1 more source

Intraosseous sarcoidosis imitating peri‐implantitis: A case study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Sarcoidosis is a multisystem granulomatous disorder of unknown cause, typically affecting the lungs and lymph nodes, but it can also involve the eyes, skin, heart, bones, and other organs. The exact cause is unclear, but genetic factors and environmental triggers like infections, chemicals, or dust may play a role.
Magdalena Orlowska, David S. Gottlieb, Kenneth S. Kornman +2 more
wiley +1 more source

Brucellosis Spondylodiscitis: A case report

مجله دانشگاه علوم پزشکی بیرجند, 2020
Brucellosis is an endemic disease in Iran that is transmitted from animal to human. The clinical manifestations of brucellosis are nonspecific and its complications involve bones and joints.
Nasrin Milani, Reza Ahmadi
doaj

Treatment recommendations for psoriatic arthritis [PDF]

, 2008
Objective: To develop comprehensive recommendations for the treatment of the various clinical manifestations of psoriatic arthritis (PsA) based on evidence obtained from a systematic review of the literature and from consensus opinion.
Ritchlin, CT +15 more
core +1 more source

Serious Infection in Crohn's Disease Patients Treated With Ustekinumab: US Food and Drug Administration Active Postmarket Risk Identification and Analysis in the Sentinel Initiative

Clinical Pharmacology &Therapeutics, EarlyView.
The U.S. Food and Drug Administration (FDA) used an Active Postmarket Risk Identification and Analysis (ARIA) system to address a safety issue (serious infection) identified during clinical review of an application to market ustekinumab as a treatment for Crohn's disease (CD). FDA used an active‐comparator new‐user cohort design, data from six Sentinel
Joel L. Weissfeld +9 more
wiley +1 more source

HLA Class I or Class II and Disease Association: Catch the Difference if You Can [PDF]

, 2017
The association of autoimmune diseases with HLA has been known for many decades. To date, however, the underlying mechanisms have not been fully understood. The recently introduced genome-wide association studies (GWAS) have suggested that several genes
Fiorillo, Mt +3 more
core +2 more sources

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