Results 71 to 80 of about 62,455 (259)

Viral mixed infection complicated by acute hepatitis and allergic toxic dermatitis (clinical case)

Современная ревматология, 2022
Epstein-Barr virus (EBV) belongs to the family of herpesviruses (herpes type 4) and is one of the most common and highly contagious. During the pandemic of a new coronavirus disease, it was found that in patients previously infected with EBV, COVID-19 ...
E. S. Aronova, B. S. Belov, G. I. Gridneva   +2 more
doaj   +1 more source

The prevalence of axial spondyloarthritis in the UK: a cross-sectional cohort study [PDF]

, 2015
Background: Accurate prevalence data are important when interpreting diagnostic tests and planning for the health needs of a population, yet no such data exist for axial spondyloarthritis (axSpA) in the UK.
Alex Macgregor, Andoni Toms, CH Roux, D Poddubnyy, E Collantes, E Tomero, Edward Pinch, F Costantino, J Sieper, JH Kellgren, JS Lawrence, Karl Gaffney, L Hamilton, L Hamilton, L Hoeven Van, Louise Hamilton, M Dougados, M Rojas-Vargas, M Rudwaleit, MR Underwood, R Angelis De, S Linden Van der, SZ Aydin, Victoria Warmington, W Mau   +24 more
core   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Epigenetics of spondyloarthritis

Joint Bone Spine, 2020
Spondyloarthritis (SpA) is a chronic inflammatory disorder resulting from a combination of genetic predisposition and environmental factors. Despite recent advances, a substantial fraction of its genetic basis remains poorly understood. Several mechanisms have been proposed to account for this unexplained heritability, including epigenetics which can ...
Cherqaoui, Bilade, Crémazy, Frédéric, Hue, Christophe, Garchon, Henri-Jean, Breban, Maxime, Costantino, Félicie   +5 more
openaire   +3 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Tuberculin skin test repetition after TNF-α inhibitors in patients with chronic inflammatory arthritis: a long-term retrospective cohort in endemic area

Advances in Rheumatology
Objectives To evaluate the tuberculin skin test (TST) conversion in chronic inflammatory arthropathies (CIA) patients on TNFα inhibitors (TNFi) and without previous latent tuberculosis infection (LTBI) treatment.
Vanessa de Oliveira Magalhães, Karina Rossi Bonfiglioli, Carina More Frade Gomes, Eloisa Bonfá, Ana Cristina de Medeiros-Ribeiro, Carla Gonçalves S. Saad, Marcelo de Medeiros Pinheiro   +6 more
doaj   +1 more source

Evaluation of Mobile Apps Targeted at Patients With Spondyloarthritis for Disease Monitoring: Systematic App Search

JMIR mHealth and uHealth, 2019
BackgroundThere are many apps developed for patients with spondyloarthritis in the market, but their purpose and quality are not objectively evaluated.
Kwan, Yu Heng, Ong, Wei Jie, Xiong, Mengfei, Leung, Ying Ying, Phang, Jie Kie, Wang, Charmaine Tze May, Fong, Warren   +6 more
doaj   +1 more source

Unmet Needs in Spondyloarthritis: Imaging in Axial Spondyloarthritis

The Journal of Rheumatology
Imaging biomarkers in axial spondyloarthritis (axSpA) are currently the most specific biomarkers for the diagnosis of this condition. Despite advances in imaging, from plain radiographs—which detect only damage—to magnetic resonance imaging (MRI)—which identifies disease activity and structural change—there are still many challenges that remain ...
Lianne S. Gensler, Lennart Jans, Sharmila Majumdar, Denis Poddubnyy   +3 more
openaire   +2 more sources

Measuring the Impact: Magnetic Resonance Imaging Response of Sacroiliac Joints to Tumor Necrosis Factor Inhibitors in Youth With Axial Disease

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the timeline for resolution of sacroiliac joint (SIJ) inflammation, changes in structural lesions, and their correlation with patient‐reported outcomes (PROs) in youth with axial juvenile spondyloarthritis (axJSpA) initiating tumor necrosis factor inhibitor (TNFi).
Timothy G. Brandon, Rui Xiao, Daniel J. Lovell, Edward Oberle, Matthew L. Stoll, Nancy A. Chauvin, Michael L. Francavilla, Walter P. Maksymowych, Pamela F. Weiss   +8 more
wiley   +1 more source

Diagnositic value of pelvic enthesitis on MRI of the sacroiliac joints in enthesitis related arthritis [PDF]

, 2015
Background: To determine the prevalence and diagnostic value of pelvic enthesitis on MRI of the sacroiliac (SI) joints in enthesitis related arthritis (ERA).
Baraliakos, X., Dehoorne, Jo, Elewaut, Dirk, Herregods, Nele, Jans, Lennart, Jaremko, J. L., Joos, R, PATTYN, EVA, Van den Bosch, Filip, Van Vlaenderen, J, Verstraete, Koenraad   +10 more
core   +1 more source