Results 51 to 60 of about 153,927 (313)

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Preparation of Hydroxyapatite Scaffold using Luffa Cylindrica Sponge as Template

Jurnal Rekayasa Kimia & Lingkungan, 2020
Hydroxyapatite (HA) scaffold has been widely applied in the biomedical field especially for bone implants. The purpose of this research is to determine the influence of dispersant addition and stirring time on HA scaffold which formed using gambas ...
Ahmad Fadli, Prihartini Widiyanti, Deni Noviana, Agung Prabowo, Heni Ismawati   +4 more
doaj   +1 more source

Conformal Metallosaccharide Hybrid Films for Protecting Wood Surfaces From Environmental Damage

Advanced Functional Materials, EarlyView.
Ti‐ribose hybrid films fabricated by molecular layer deposition form a conformal and uniform coating on wood surfaces, which provides water repellence, dimensional stability, and resistance to acidic and alkaline environments, while preserving the natural appearance.
Wenwen Wang, Aranzazu Sierra Fernandez, Gabriele Botta, Evgenii Modin, Iva Šarić Janković, Shidong Ji, Junli Liu, Mato Knez   +7 more
wiley   +1 more source

Isolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge haliclona simulans

, 2014
The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol.
Ooi, Thengtheng, Kennedy, Jonathan, Gráinne Abbott, Thengtheng Ooi, Abbott, Gráinne, Viegelmann, Christina, RuAngelie Edrada-Ebel, Parker, Jennifer, Dobson, Alan D W, Edrada-Ebel, RuAngelie, Jennifer Parker, Jonathan Kennedy, Carol Clements, Alan D. W. Dobson, Clements, Carol, Alan Dobson, Christina Viegelmann, Young, Louise, Louise Young   +18 more
core   +1 more source

Sponge-Associated Amphipod Communities as Bioindicators for Pollution

, 2020
Pollution negatively impacts organisms across all marine ecosystems. Coastal areas are particularly vulnerable to pollution due to their proximity to human settlements.
Hauke, Ronja (11813996)
core   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity [PDF]

, 2013
Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3).
Calcinai, Barbara, Orazio Taglialatela Scafati, Henny A. Dien, Henny Dien, Dien, Henny, C. Cerrano, TAGLIALATELA SCAFATI, ORAZIO, Fernando Scala, Taglialatela-Scafati, Orazio, Kaiser, Marcel, M. Kaiser, Tasdemir, Deniz, Marcel Kaiser, Carlo Cerrano, Chianese, Giuseppina, Dien, Henny A., B. Calcinai, Deniz Tasdemir, D. Tasdemir, Scala, Fernando, Barbara Calcinai, Giuseppina Chianese, H. A. Dien, Orazio Taglialatela-Scafati, Cerrano, Carlo   +24 more
core   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Impacts of Climatic Change on Reference Crop Evapotranspiration across Different Climatic Zones of Ningxia at Multi-Time Scales from 1957 to 2018

Advances in Meteorology, 2020
The impact of global climate change on agroecosystems is growing, affecting reference crop evapotranspiration (ET0) and subsequent agricultural water management.
Ziyang Zhao, Hongrui Wang, Cheng Wang, Wangcheng Li, Hao Chen, Shuxin Gong   +5 more
doaj   +1 more source

CircRNA-Associated CeRNAs Regulatory Axes in Retinoblastoma: A Systematic Scoping Review

Frontiers in Oncology, 2022
Retinoblastoma (RB) is one of the most common childhood cancers caused by RB gene mutations (tumor suppressor gene in various patients). A better understanding of molecular pathways and the development of new diagnostic approaches may lead to better ...
Mohammad Reza Asadi, Marziyeh Sadat Moslehian, Hani Sabaie, Mirmohsen Sharifi-Bonab, Parvin Hakimi, Bashdar Mahmud Hussen, Bashdar Mahmud Hussen, Mohammad Taheri, Mohammad Taheri, Azadeh Rakhshan, Maryam Rezazadeh, Maryam Rezazadeh   +11 more
doaj   +1 more source