Results 41 to 50 of about 1,015,712 (340)

Single Fusion Pore Analysis via Single Cell Amperometry Uncovers Impaired Pore Expansion That Restricts Insulin Exocytosis in Human Type 2 Diabetes

Angewandte Chemie, EarlyView.
The final step in insulin exocytosis from pancreatic beta cells is the formation of the fusion pore. We combined single‐cell amperometry with microsensors and fluorescence microscopy to monitor insulin exocytosis from different perspectives. Our results reveal a link between impaired fusion pore function and diminished insulin secretion, highlighting ...
Amir Hatami, Nikhil R. Gandasi, Haiqiang Dou, Lakshmi Kothegala, Lena Eliasson, Andrew Ewing, Patrik Rorsman   +6 more
wiley   +2 more sources

Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion

Ecotoxicology and Environmental Safety
Exposure to specific alkali and alkaline earth elements(AEs/AEEs) has been reported that are linked to an increased risk of spontaneous abortion. However, the direct evidence of exposure in the uterus are absent.
Meng Lin, Yutong Wang, Xiaoye Wang, Lailai Yan, Linlin Wang, Chan Tian   +5 more
doaj   +1 more source

The effect of diagnostic amniocentesis and its complications on early spontaneous abortion

Electronic Physician, 2016
Introduction: The occurrence of early abortion after amniocentesis is a serious problem in the fields of obstetrics and gynecology, and it is always important to discover the factors influencing this phenomenon.
Fatemeh Tara, Marzieh Lotfalizadeh, Somayeh Moeindarbari   +2 more
doaj   +1 more source

Advances in Understanding the Immune Imbalance between T-Lymphocyte Subsets and NK Cells in Recurrent Spontaneous Abortion

Geburtshilfe und Frauenheilkunde, 2018
Recurrent spontaneous abortion is a global problem, and unexplained recurrent abortion triggered by immunological factors is an important focus of current research.
Xiaoxuan Zhao, Yue-Peng Jiang, Lin Wang, Zhihao Li, Qiang Li, Xiaoling Feng   +5 more
semanticscholar   +1 more source

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation

Advanced Science, EarlyView.
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui, Xinhang Meng, Yujie Luo, Jinfeng Qian, Fengrun Sun, Mingke Qiu, Songcun Wang   +6 more
wiley   +1 more source

Association between Abortion and All-Cause and Cause-Specific Premature Mortality: A Prospective Cohort Study from the UK Biobank

Health Data Science
Background: Concerns have been raised about the increasing prevalence of both spontaneous and induced abortions worldwide, yet their effect on premature mortality remains poorly understood.
Shaohua Yin, Yingying Yang, Qin Wang, Wei Guo, Qian He, Lei Yuan, Keyi Si   +6 more
doaj   +1 more source

The role of complete blood inflammation markers in the prediction of spontaneous abortion

Pakistan Journal of Medical Sciences, 2018
Objective: To investigate relationships between spontaneous abortion and complete blood count inflammation markers and their role in predicting spontaneous abortion.
Funda Yildirim Bas, E. Tola, Suheyla Sak, Basak Asli Cankaya   +3 more
semanticscholar   +1 more source

Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage

Advanced Science, EarlyView.
Li exposure up‐regulates FOXO1 expression levels and thus promotes FOXO1‐mediated STEAP4 transcription, up‐regulating STEAP4 levels. Subsequently, STEAP4 up‐regulates intracellular Cu+ ion levels and causes cuproptosis, which further induces miscarriage.
Shuaishuai Xing, Yanbing Lin, Yi Sun, Xiaoping Yue, Qigang Fan, Jisheng Nie, Zhihong Zhang, Yajing Liu, Juntang Yang, Qingzheng Kang, Yanxin Wang, Haijun Yan, Chan Tian, Ying Chang, Huidong Zhang   +14 more
wiley   +1 more source

Use of antibiotics during pregnancy and risk of spontaneous abortion

Canadian Medical Association Journal, 2017
BACKGROUND: Although antibiotics are widely used during pregnancy, evidence regarding their fetal safety remains limited. Our aim was to quantify the association between antibiotic exposure during pregnancy and risk of spontaneous abortion.
F. Muanda, O. Sheehy, A. Bérard
semanticscholar   +1 more source

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source